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中华临床医师杂志(电子版) ›› 2017, Vol. 11 ›› Issue (13) : 2002 -2005. doi: 10.3877/cma.j.issn.1674-0785.2017.13.009

所属专题: 文献

综述

L1细胞黏附分子在早期子宫内膜癌中研究进展
王庆敏1, 尹香花2,()   
  1. 1. 116044 大连医科大学;225001 扬州,江苏省苏北人民医院妇产科
    2. 225001 扬州,江苏省苏北人民医院妇产科
  • 收稿日期:2016-04-10 出版日期:2017-07-01
  • 通信作者: 尹香花

Progress in research of L1CAM in early endometrial carcinoma

Qingmin Wang1, Xianghua Yin2,()   

  1. 1. Department of Gynecology and Obstetrics, Dlian Medical University, Dalian 116044, China; Department of Gynecology and Obstetrics, Subei People′s Hospital, Yangzhou 225001, China
    2. Department of Gynecology and Obstetrics, Subei People′s Hospital, Yangzhou 225001, China
  • Received:2016-04-10 Published:2017-07-01
  • Corresponding author: Xianghua Yin
  • About author:
    Corresponding author: Yin Xianghua, Email:
引用本文:

王庆敏, 尹香花. L1细胞黏附分子在早期子宫内膜癌中研究进展[J/OL]. 中华临床医师杂志(电子版), 2017, 11(13): 2002-2005.

Qingmin Wang, Xianghua Yin. Progress in research of L1CAM in early endometrial carcinoma[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2017, 11(13): 2002-2005.

L1细胞黏附分子(L1CAM)是一种细胞间黏附分子,由一系列蛋白分子以线性结构连接组成,在调控神经细胞运动、生长等方面发挥重要作用。研究表明,肿瘤细胞中表达L1CAM可促进细胞增殖、迁移、侵袭与转移,从而影响肿瘤患者的预后。近期有文献报道通过免疫组化等方法检测L1CAM在早期子宫内膜癌(EC)组织中的表达情况,联合临床数据,分析了L1CAM对EC患者预后的不良影响。本文通过阐述L1CAM在肿瘤细胞转移中的相关机制,尤其对其和上皮间质转化(EMT)机制关系的相关研究,概述其对EC患者预后影响的相关研究结果,为进一步探讨EC的不良预后因素从而制定更精准的后续治疗方案提供依据。

L1 cell adhesion molecule (L1CAM) is a kind of cell adhesion molecule consisting of a series of protein domains, playing an important role in the regulation of nerve cell movement and growth. Studies show that L1CAM expressed in tumor cells can promote cell proliferation, migration, invasion, and metastasis, which affects the prognosis of patients with tumors. Recently, some researchers have detected L1CAM expression in early endometrial carcinoma tissue by immunohistochemistry and analyzed the adverse influence of L1CAM on the prognosis of patients with endometrial carcinoma. This article discusses the mechanism of L1CAM in tumor cell metastasis, especially the relationship between L1CAM and epithelial-mesenchymal transition (EMT), and its influence on the prognosis of patients with endometrial cancer, in order to further explore the adverse prognostic factors of endometrial carcinoma and provide evidence for more precise treatment of this malignancy.

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