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中华临床医师杂志(电子版) ›› 2017, Vol. 11 ›› Issue (14) : 2019 -2022. doi: 10.3877/cma.j.issn.1674-0785.2017.14.002

所属专题: 文献

临床论著

胸腔积液中环氧化酶-2与血管内皮生长因子的表达及临床意义
赵方正1, 郑新华2, 黄传君2, 邓鹏辉3, 宫晓丹4, 张才擎5,()   
  1. 1. 250355 济南,山东中医药大学2015级研究生;250014 济南,山东省千佛山医院呼吸内科
    2. 250355 济南,山东中医药大学2015级研究生
    3. 271000 泰安,泰山医学院
    4. 250014 济南,山东大学医学院
    5. 250014 济南,山东省千佛山医院呼吸内科
  • 收稿日期:2017-03-07 出版日期:2017-07-15
  • 通信作者: 张才擎
  • 基金资助:
    山东省自然科学基金(ZR2013HM046)

Clinical significance of expression of cyclooxygenase-2 and vascular endothelial growth factor in pleural effusion

Fangzheng Zhao1, Xinhua Zheng2, Chuanjun Huang2, Penghui Deng3, Xiaodan Gong4, Caiqing Zhang5,()   

  1. 1. Shandong University of Traditional Chinese Medicine, Jinan 250355, China; Department of Respiratory Medicine, Shandong Provincial Qianfoshan Hospital, Jinan 250014, China
    2. Shandong University of Traditional Chinese Medicine, Jinan 250355, China
    3. Taishan Medical University, Taian 271000, China
    4. School of Medicine, Shandong University, Jinan 250014, China
    5. Department of Respiratory Medicine, Shandong Provincial Qianfoshan Hospital, Jinan 250014, China
  • Received:2017-03-07 Published:2017-07-15
  • Corresponding author: Caiqing Zhang
  • About author:
    Corresponding author: Zhang Caiqing, Email:
引用本文:

赵方正, 郑新华, 黄传君, 邓鹏辉, 宫晓丹, 张才擎. 胸腔积液中环氧化酶-2与血管内皮生长因子的表达及临床意义[J/OL]. 中华临床医师杂志(电子版), 2017, 11(14): 2019-2022.

Fangzheng Zhao, Xinhua Zheng, Chuanjun Huang, Penghui Deng, Xiaodan Gong, Caiqing Zhang. Clinical significance of expression of cyclooxygenase-2 and vascular endothelial growth factor in pleural effusion[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2017, 11(14): 2019-2022.

目的

通过胸腔积液中环氧化酶-2(COX-2)及血管内皮生长因子(VEGF)含量的测定,探讨COX-2、VEGF对良恶性胸腔积液的鉴别诊断价值及意义。

方法

选取于2015年6月至2016年8月在山东省千佛山医院就诊并确诊的48例恶性胸腔积液、10例良性胸腔积液,酶联免疫吸附法(ELISA法)测定胸腔积液中COX-2、VEGF的表达水平,比较COX-2、VEGF在良恶性胸腔积液中表达的差异。

结果

48例恶性胸腔积液及10例良性胸腔积液中COX-2、VEGF表达量与性别、年龄无明显关系(P>0.05)。恶性胸腔积液中COX-2、VEGF表达量为(788.04±128.85)U/L、(365.27±80.63)ng/L,良性胸腔积液中COX-2、VEGF表达量为(366.92±41.08)U/L、(114.67±15.69)ng/L,恶性胸腔积液中COX-2、VEGF表达水平显著高于良性胸腔积液,差异具有统计学意义(P<0.001)。

结论

恶性胸腔积液中COX-2、VEGF的表达显著高于良性胸腔积液,有望成为良恶性胸腔积液鉴别诊断的有效指标。

Objective

To assess the significance of COX-2 and VEGF in the differential diagnosis of benign and malignant pleural effusions by detecting their levels in pleural effusion.

Methods

Fifty-eight cases of pleural effusion were collected at our hospital, including 48 cases of malignant pleural effusion and 10 cases of benign pleural effusion. Expression levels of COX-2 and VEGF in pleural effusions were detected by ELISA and compared between benign and malignant pleural effusions.

Results

The expression levels of COX-2 and VEGF had no significant association with gender or age in both 48 cases of malignant pleural effusion and 10 cases of benign pleural effusion (P>0.05). The average COX-2 and VEGF levels were (788.04 ± 128.85) U/L and (365.27 ± 80.63) ng/L, respectively, in the malignant pleural effusion group, and the corresponding values in the benign pleural effusion group were (366.92 ± 41.08) U/L and (114.67 ± 15.69) ng/L. COX-2 and VEGF levels in malignant pleural effusion were significantly higher than those in benign pleural effusion (P<0.001).

Conclusion

COX-2 and VEGF expression levels are higher in malignant pleural effusion than in benign pleural effusion, and they may serve as prognostic factors to distinguish between benign and malignant pleural effusions.

表1 2组胸腔积液中COX-2、VEGF含量的比较(±s
表2 不同肿瘤组胸腔积液COX-2、VEGF含量的比较(±s
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