切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2019, Vol. 13 ›› Issue (01) : 7 -12. doi: 10.3877/cma.j.issn.1674-0785.2019.01.002

所属专题: 文献

临床研究

红细胞分布宽度在儿童过敏性紫癜中的临床价值
李新叶1, 陆元奉1, 唐慧荷1, 石丰浪1, 郑凯元1, 杨益梅1, 代艳1,()   
  1. 1. 530000 南宁,广西壮族自治区人民医院儿科
  • 收稿日期:2018-10-30 出版日期:2019-01-01
  • 通信作者: 代艳
  • 基金资助:
    广西壮族自治区卫生厅基金资助项目(Z2010229)

Clinical value of red blood cell distribution width in children with Henoch-Schönlein purpura

Xinye Li1, Yuanfeng Lu1, Huihe Tang1, Fenglang Shi1, Kaiyuan Zheng1, Yimei Yang1, Yan Dai1,()   

  1. 1. Department of pediatrics, the people's Hospital of Guangxi zhuang Autonomous Region, Nanning 530000, China
  • Received:2018-10-30 Published:2019-01-01
  • Corresponding author: Yan Dai
  • About author:
    Corresponding author: Dai Yan, Email:
引用本文:

李新叶, 陆元奉, 唐慧荷, 石丰浪, 郑凯元, 杨益梅, 代艳. 红细胞分布宽度在儿童过敏性紫癜中的临床价值[J/OL]. 中华临床医师杂志(电子版), 2019, 13(01): 7-12.

Xinye Li, Yuanfeng Lu, Huihe Tang, Fenglang Shi, Kaiyuan Zheng, Yimei Yang, Yan Dai. Clinical value of red blood cell distribution width in children with Henoch-Schönlein purpura[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(01): 7-12.

目的

探讨红细胞分布宽度(RDW)在儿童过敏性紫癜(HSP)中的临床价值。

方法

收集2013年1月至2018年5月在广西壮族自治区人民医院儿科住院的HSP患儿的资料,根据是否存在肾脏损害分为紫癜性肾炎(HSPN)组和过敏性紫癜无肾炎(HSPWN)组,同时设置同期健康儿童作为对照组。对HSP患儿和健康儿童,HSPN、HSPWN患儿与健康儿童,血红细胞(RBC)、血小板(PLT)的两组间比较采用两样本t检验,三组间比较采用one-Way ANOVA;年龄,血白细胞(WBC)、血红蛋白(Hb)、红细胞比容(Hct)、红细胞平均体积(MCV)、红细胞分布宽度变异系数(RDW-CV)、红细胞分布宽度标准差(RDW-SD)和血小板平均体积(MPV)的组间比较采用秩和检验;性别分布的组间比较采用χ2检验。任意两组间比较采用Kruskal-Wallis检验(视图中选择pairwise comparisons)。HSP患儿RDW-CV、RDW-SD与其他指标的相关性分析采用Spearman秩相关分析。

结果

HSP患儿与健康儿童在性别,年龄,血MCV、PLT、MPV方面差异无统计学意义(P均>0.05)。HSP患儿血WBC,RDW-CV、RDW-SD水平较健康儿童显著增高,差异有统计学意义(Z=-6.838,P<0.001;Z=-5.437,P<0.001;Z=-4.681,P<0.001);血RBC,Hb、Hct水平较健康儿童显著降低,差异有统计学意义(t=-2.701,P=0.008;Z=-4.396,P<0.001;Z=-4.043,P<0.001)。HSPN、HSPWN患儿与健康儿童在性别,年龄,血MCV、PLT、MPV方面差异无统计学意义(P均>0.05)。HSPN、HSPWN患儿与健康儿童比较,血WBC、RDW-CV、RDW-SD水平明显升高,差异有统计学意义(Z=46.760,P<0.001;Z=32.984,P<0.001;Z=28.343,P<0.001);而血RBC、Hb、Hct水平明显降低,差异有统计学意义(t=4.375,P=0.014;Z=20.623,P<0.001;Z=18.256,P<0.001)。HSPN患儿与HSPWN患儿比较,血RDW-SD水平明显升高,差异有统计学意义(P<0.05),其余指标差异无统计学意义(P均>0.05)。HSP患儿血RDW-CV与WBC、RBC和RDW-SD呈正相关(r=0.189,P=0.047;r=0.263,P=0.005;r=0.217,P=0.023),与Hb、Hct、MCV呈负相关(r=-0.329,P<0.001;r=-0.194,P=0.042;r=-0.447,P<0.001),未发现RDW-CV水平与CRP、Fib、D-二聚体和总胆固醇水平之间的相关性(r=0.029,0.021,-0.143,0.015,P均>0.05)。HSP患儿血RDW-SD水平与MCV、RDW-CV、总胆固醇水平之间呈正相关(r=0.434,P<0.001;r=0.217,P=0.023;r=0.360,P<0.001),与RBC、D-二聚体水平呈负相关(r=-0.213,P=0.026;r=-0.301,P=0.003),未发现RDW-SD与WBC、Hb、Hct、CRP、Fib水平之间的相关性(r=-0.027,0.060,0.139,-0.073,-0.195,P均>0.05)。

结论

HSP患儿RDW水平升高,但RDW在评估HSP患儿能否进展为HSPN方面仍有待进一步研究。

Objective

To investigate the clinical value of red blood cell distribution width (RDW) in children with Henoch-Sch?nlein purpura (HSP).

Methods

The data of children with HSP who were hospitalized at the Department of Pediatrics of the People′s Hospital of Guangxi Zhuang Autonomous Region from January 2013 to May 2018 were collected. According to the presence of kidney damage or not, the patients were divided into a Henoch-Sch?nlein Purpura nephritis (HSPN) group and a HSP without nephritis (HSPWN) group. Healthy children were included as a control group. For children with HSP and healthy children as well as HSPN children, HSPWN children, and healthy children, red blood cell (RBC) count, platelet (PLT) count were compared between two groups using two-sample t-test and among three groups using one-way ANOVA. The Wilcoxon rank sum test was used for comparison of age, white blood cell (WBC) count, hemoglobin (Hb), hematocrit (Hct), red blood cell distribution width variation coefficient (RDW-CV), red blood cell distribution width standard deviation (RDW-SD), and platelet mean volume (MPV) between groups. The χ2 test was used for comparison of gender between groups. The Kruskal-Wallis test was used for comparison between any two groups (pairwise comparisons were selected in the view). Correlation analysis between RDW-CV, RDW-SD, and other indicators in children with HSP was performed by Spearman rank correlation analysis.

Results

There were no significant differences between HSP children and healthy children in gender, age, MCV, PLT count, or MPV (P>0.05). Blood WBC count, RDW-CV, and RDW-SD were significantly higher in children with HSP than in healthy children (Z=-6.838, P<0.001; Z=-5.437, P<0.001; Z=-4.681, P<0.001), while RBC count, Hb, and Hct were significantly lower in children with HSP than in healthy children (t=-2.701, P=0.008; Z=-4.396, P<0.001; Z=-4.043, P<0.001). There were no significant differences in gender, age, MCV, PLT count, or MPV among children with HSPN, those with HSPWN, and healthy children (P>0.05). Compared with healthy children, children with HSPN and HSPWN had significantly higher blood WBC count, RDW-CV, and RDW-SD (Z=46.760, P<0.001; Z=32.984, P<0.001; Z=28.343, P<0.001), but significantly lower blood RBC count, Hb, and Hct (t=4.375, P=0.014; Z=20.623, P<0.001; Z=18.256, P<0.001). Compared with children with HSPWN, RDW-SD in HSPN patients was significantly higher (P<0.05), but the other indicators were not statistically significant between the two groups (P>0.05). RDW-CV was positively correlated with blood WBC, RBC count, and RDW-SD in children with HSP (r=0.189, P=0.047; r=0.263, P=0.005; r=0.217, P=0.023), and negatively correlated with Hb, Hct, and MCV (r=-0.329, P<0.001; r=-0.194, P=0.042; r=-0.447, P<0.001). RDW-CV had no correlation with CRP, Fib, D-dimer, or cholesterol (r=0.029, 0.021, -0.143, and 0.015, respectively, P>0.05). RDW-SD had a positive correlation with MCV, RDW-CV, and cholesterol in children with HSP (r=0.434, P<0.001; r=0.217, P=0.023; r=0.360, P<0.001), but had a negative correlation with RBC count and D-dimer (r=-0.213, P=0.026; r=-0.301, P=0.003). RDW-SD had no correlation with WBC count, Hb, Hct, CRP, or Fib (r=-0.027, 0.060, 0.139, -0.073, and -0.195, respectively, P>0.05).

Conclusion

RDW is elevated in children with HSP, but it remains to be further studied whether RDW can predict the progression of HSP to HSPN in children.

表1 HSP患儿与健康儿童性别、年龄和血常规检查结果比较
表2 HSPN患儿、HSPWN患儿与健康儿童年龄、性别和血常规检查结果比较
表3 HSP患儿血RDW-CV与其他指标的相关性
表4 HSP患儿血RDW-SD与其他指标的相关性
1
Pohl M.Henoch-Schönlein purpura nephritis [J]. Pediatr Nephrol, 2015, 30(2): 245-252.
2
Zhu X, Zhang M, Lan F, et al. The relationship between red cell distribution width and the risk of Henoch-Schönlein purpura nephritis [J]. Br J Biomed Sci, 2018, 75(1): 30-35.
3
Xu H, Li W, Mao JH, et al. Association between red blood cell distribution width and Henoch-Schonlein purpura nephritis [J]. Medicine (Baltimore), 2017, 96(23): e7091.
4
中华医学会儿科学分会免疫学组. 儿童过敏性紫癜循证诊治建议[J]. 中华儿科杂志, 2013, 51 (7): 502-507.
5
中华医学会儿科学分会肾脏病学组.儿童常见肾脏疾病诊治循证指南(二):紫癜性肾炎的诊治循证指南(试行) [J]. 中华儿科杂志, 2009, 47(12): 911-913.
6
Davin JC. Henoch-Schonlein purpura nephritis: pathophysiology, treatment, and future strategy [J]. Clin J Am Soc Nephrol, 2011, 6(3): 679-689.
7
Kawasaki Y, Ono A, Ohara S, et al. Henoch-Schönlein purpura nephritis in childhood: pathogenesis, prognostic factors and treatment [J]. Fukushima J Med Sci, 2013, 59(1):15-26.
8
Pillebout E, Jamin A, Ayari H, et al. Biomarkers of IgA vasculitis nephritis in children [J]. PLoS One, 2017, 12(11): e0188718.
9
López-Mejías R, Castañeda S, Genre F, et al. Genetics of immunoglobulin-A vasculitis (Henoch-Schönlein purpura): an updated review [J]. Autoimmun Rev,2018, 17(3):301-315.
10
Xu H, Pan Y, Li W, et al. Association between IL17A and IL17F polymorphisms and risk of Henoch-Schonlein purpura in Chinese children [J]. Rheumatol Int, 2016, 36(6): 829-835.
11
Chao TK, Rifai A, Ka SM, et al. The endogenous immune response modulates the course of IgA-immune complex mediated nephropathy [J]. Kidney Int, 2006, 70(2): 283-297.
12
Zhang Z, Zhao S, Zhang L, et al. A higher frequency of CD4(+)CXCR5(+) T follicular helper cells in patients with newly diagnosed Henoch-Schönlein purpura nephritis [J]. Int Immunopharmacol, 2016, 32: 8-15.
13
Miyamoto K, Inai K, Takeuchi D, et al. Relationships among red cell distribution width, anemia, and interleukin-6 in adult congenital heart disease [J]. Circ J, 2015, 79(5): 1100-1106.
14
Nada AM.Red cell distribution width in type 2 diabetic patients [J]. Diabetes Metab Syndr Obes, 2015, 8: 525-533.
15
Ay S, Eryilmaz MA, Aksoy N, et al.Is early detection of colon cancer possible with red blood cell distribution width? [J]. Asian Pac J Cancer Prev, 2015, 16(2): 753-756.
16
Song CS, Park DI, Yoon MY, et al. Association between red cell distribution width and disease activity in patients with inflammatory bowel disease [J]. Dig Dis Sci, 2012, 57(4): 1033-1038.
17
Rodríguez-Carrio J, Alperi-López M, López P, et al. Red cell distribution width is associated with cardiovascular risk and disease parameters in rheumatoid arthritis [J]. Rheumatology (Oxford), 2015, 54(4): 641-646.
18
Jo YH, Kim K, Lee JH, et al. Red cell distribution width is a prognostic factor in severe sepsis and septic shock [J]. Am J Emerg Med, 2013, 31(3): 545-548.
19
Solak Y, Yilmaz MI, Saglam M, et al. Red cell distribution width is independently related to endothelial dysfunction in patients with chronic kidney disease [J]. Am J Med Sci, 2014, 347(2): 118-124.
20
Hong J, Yang HR.Laboratory markers indicating gastrointestinal involvement of henoch-schönlein purpura in children [J]. Pediatr Gastroenterol Hepatol Nutr, 2015, 18(1): 39-47.
21
王芳,张迎辉. 胱抑素C、纤维蛋白原及24 h尿蛋白定量与紫癜性肾炎患儿肾脏病理分级的相关性研究[J]. 中国当代儿科杂志, 2016, 18(3): 233-237.
[1] 陶宏宇, 叶菁菁, 俞劲, 杨秀珍, 钱晶晶, 徐彬, 徐玮泽, 舒强. 右心声学造影在儿童右向左分流相关疾病中的评估价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(10): 959-965.
[2] 刘琴, 刘瀚旻, 谢亮. 基质金属蛋白酶在儿童哮喘发生机制中作用的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 564-568.
[3] 向韵, 卢游, 杨凡. 全氟及多氟烷基化合物暴露与儿童肥胖症相关性研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 569-574.
[4] 王雅楠, 刘丹, 曹正浓, 贾慧敏. 儿童迟发性先天性膈疝患儿的临床诊治特点分析[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(04): 410-419.
[5] 陈桂华, 钟小玲, 谢雨, 王慧, 谢江, 杨涛毅. 合并肝脏疾病特殊健康状态儿童疫苗预防接种及时性临床分析[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(04): 431-439.
[6] 雷丽莉, 于晓峰, 王媛媛, 徐迎军. 人鼻病毒感染喘息急性发作儿童外周血NLRP3和TLR4水平及临床意义[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(04): 440-445.
[7] 郑宝英, 黄小兰, 贾楠, 朱春梅. 儿童难治性肺炎支原体肺炎早期预警指标[J/OL]. 中华实验和临床感染病杂志(电子版), 2024, 18(04): 215-221.
[8] 刘冉佳, 崔向丽, 周效竹, 曲伟, 朱志军. 儿童肝移植受者健康相关生存质量评价的荟萃分析[J/OL]. 中华移植杂志(电子版), 2024, 18(05): 302-309.
[9] 丁荷蓓, 王珣, 陈为国. 七氟烷吸入麻醉与异丙酚静脉麻醉在儿童腹股沟斜疝手术中的应用比较[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 570-574.
[10] 中华医学会器官移植学分会, 中华医学会外科学分会外科手术学学组, 中华医学会外科学分会移植学组, 华南劈离式肝移植联盟. 劈离式供肝儿童肝移植中国临床操作指南[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 593-601.
[11] 刘军, 丘文静, 孙方昊, 李松盈, 易述红, 傅斌生, 杨扬, 罗慧. 在体与离体劈离式肝移植在儿童肝移植中的应用比较[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 688-693.
[12] 张琛, 秦鸣, 董娟, 陈玉龙. 超声检查对儿童肠扭转缺血性改变的诊断价值[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 565-568.
[13] 王晓瑜, 郭群英, 牛雅萌, 赵成松. 公立儿童医院促进儿科就医均等化实践探析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(04): 383-387.
[14] 陈晓胜, 何佳, 刘方, 吴蕊, 杨海涛, 樊晓寒. 直立倾斜试验诱发31 秒心脏停搏的植入心脏起搏器儿童一例并文献复习[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 488-494.
[15] 曹亚丽, 高雨萌, 张英谦, 李博, 杜军保, 金红芳. 儿童坐位不耐受的临床进展[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 510-515.
阅读次数
全文


摘要