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中华临床医师杂志(电子版) ›› 2019, Vol. 13 ›› Issue (03) : 214 -220. doi: 10.3877/cma.j.issn.1674-0785.2019.03.012

所属专题: 文献

综述

晚期胆管癌的药物治疗现状
宗源1, 周军1, 沈琳1,()   
  1. 1. 100142 北京大学临床肿瘤学院 北京肿瘤医院暨北京市肿瘤防治研究所消化肿瘤内科 恶性肿瘤发病机制及转化研究教育部重点实验室
  • 收稿日期:2018-11-18 出版日期:2019-02-01
  • 通信作者: 沈琳

Current status of pharmacological therapy of advanced cholangiocarcinomas

Yuan Zong1, Jun Zhou1, Lin Shen1,()   

  1. 1. Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China
  • Received:2018-11-18 Published:2019-02-01
  • Corresponding author: Lin Shen
  • About author:
    Corresponding author: Shen Lin, Email:
引用本文:

宗源, 周军, 沈琳. 晚期胆管癌的药物治疗现状[J]. 中华临床医师杂志(电子版), 2019, 13(03): 214-220.

Yuan Zong, Jun Zhou, Lin Shen. Current status of pharmacological therapy of advanced cholangiocarcinomas[J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(03): 214-220.

胆管癌发病率低,恶性程度高,预后差。吉西他滨联合顺铂是晚期胆管癌的标准一线治疗,其疗效并不突出;同时,胆管癌缺乏标准二线治疗,亟需探索新的治疗方法。抗表皮生长因子受体、血管内皮生长因子、人类表皮生长因子受体-2等分子靶向治疗在化疗基础上均无突破,但靶向成纤维细胞生长因子受体2基因融合、IDH1/2基因突变等新靶点的治疗展现出前景。免疫检查点抑制剂、细胞因子、过继细胞治疗、肿瘤疫苗等免疫治疗也正在胆管癌中进行尝试。本文将对晚期胆管癌的药物治疗现状进行综述。

Cholangiocarcinoma (CCA) is a rare but aggressive malignancy with a poor prognosis. For advanced disease, the standard therapeutic options are limited to systemic chemotherapy with gemcitabine and cisplatin, which have suboptimal outcomes. There is no established second-line systemic therapy and emerging new therapies are being developed. Targeted therapies inhibiting epidermal growth factor receptor, vascular endothelial growth factor, human epidermal growth factor receptor 2, and others are broadly tested in CCA. Unfortunately, they have not shown much clinically meaningful benefits over the standard care of chemotherapy. Early clinical trials of therapies targeting novel genomic alterations such as fibroblast growth factor receptor 2 fusion and IDH1/2 mutations are in progress and show promising results. Immunotherapy, especially immune checkpoint inhibitors, holds great promise. Clinical trials of immune checkpoint inhibitors, cytokines, adoptive cell therapy, and vaccines in patients with CCA are in progress. Herein, we review the current status of pharmacological therapy of advanced CCA.

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