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中华临床医师杂志(电子版) ›› 2022, Vol. 16 ›› Issue (11) : 1045 -1049. doi: 10.3877/cma.j.issn.1674-0785.2022.11.003

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抗滋养层细胞表面抗原2靶向药:乳腺癌新的靶向治疗
张虹1,(), 张爽1, 杨凡2   
  1. 1. 100034 北京,北京大学第一医院病理科
    2. 100034 北京,北京大学第一医院乳腺疾病中心
  • 收稿日期:2022-09-05 出版日期:2022-11-15
  • 通信作者: 张虹

Anti-trophoblast cell surface antigen 2 targeted drugs: a new targeted therapy for breast cancer

Hong Zhang1,(), Shuang Zhang1, Fan Yang2   

  1. 1. Department of Pathology, Peking University Frist Hospital, Beijing 100034, China
    2. Department of Breast Disease Center, Peking University Frist Hospital, Beijing 100034, China
  • Received:2022-09-05 Published:2022-11-15
  • Corresponding author: Hong Zhang
引用本文:

张虹, 张爽, 杨凡. 抗滋养层细胞表面抗原2靶向药:乳腺癌新的靶向治疗[J]. 中华临床医师杂志(电子版), 2022, 16(11): 1045-1049.

Hong Zhang, Shuang Zhang, Fan Yang. Anti-trophoblast cell surface antigen 2 targeted drugs: a new targeted therapy for breast cancer[J]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(11): 1045-1049.

乳腺癌是常见的恶性肿瘤,具有显著异质性,经过标准治疗后大多患者预后良好,但仍有一些乳腺癌侵袭性高、预后差,特别是三阴性乳腺癌,需要开发出更新的治疗策略。抗滋养层细胞表面抗原2(Trop2)在乳腺癌中普遍呈表达率高,可成为具有潜力的治疗靶点,目前在药物研发和肿瘤治疗中也取得了一些进展,有些已经获批应用于临床,尤其是抗体药物偶联物类抗Trop2药物。本文将对Trop2的生物学功能、抗Trop2靶向药在乳腺癌的治疗最新进展等方面进行综述。

Breast cancer is a common malignant tumor with significant heterogeneity. After standard treatment, most patients have a good prognosis, but there are still some breast cancer cases with rapid progression and poor prognosis, especially triple negative breast cancer. Therefore, some new treatment strategies are required. Trophoblast cell surface antigen 2 (Trop2) has a high expression rate in breast cancer and may become a potential therapeutic target. At present, there are some developments in drug research and tumor treatment, and some have been approved for clinical application, especially anti-Trop2 antibody–drug conjugate drugs. This article will review the biological function of Trop2 and the latest progress in the anti-Trop-2 targeted treatment of breast cancer.

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