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中华临床医师杂志(电子版) ›› 2022, Vol. 16 ›› Issue (11) : 1045 -1049. doi: 10.3877/cma.j.issn.1674-0785.2022.11.003

所属专题: 乳腺疾病

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抗滋养层细胞表面抗原2靶向药:乳腺癌新的靶向治疗
张虹1,(), 张爽1, 杨凡2   
  1. 1. 100034 北京,北京大学第一医院病理科
    2. 100034 北京,北京大学第一医院乳腺疾病中心
  • 收稿日期:2022-09-05 出版日期:2022-11-15
  • 通信作者: 张虹

Anti-trophoblast cell surface antigen 2 targeted drugs: a new targeted therapy for breast cancer

Hong Zhang1,(), Shuang Zhang1, Fan Yang2   

  1. 1. Department of Pathology, Peking University Frist Hospital, Beijing 100034, China
    2. Department of Breast Disease Center, Peking University Frist Hospital, Beijing 100034, China
  • Received:2022-09-05 Published:2022-11-15
  • Corresponding author: Hong Zhang
引用本文:

张虹, 张爽, 杨凡. 抗滋养层细胞表面抗原2靶向药:乳腺癌新的靶向治疗[J/OL]. 中华临床医师杂志(电子版), 2022, 16(11): 1045-1049.

Hong Zhang, Shuang Zhang, Fan Yang. Anti-trophoblast cell surface antigen 2 targeted drugs: a new targeted therapy for breast cancer[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(11): 1045-1049.

乳腺癌是常见的恶性肿瘤,具有显著异质性,经过标准治疗后大多患者预后良好,但仍有一些乳腺癌侵袭性高、预后差,特别是三阴性乳腺癌,需要开发出更新的治疗策略。抗滋养层细胞表面抗原2(Trop2)在乳腺癌中普遍呈表达率高,可成为具有潜力的治疗靶点,目前在药物研发和肿瘤治疗中也取得了一些进展,有些已经获批应用于临床,尤其是抗体药物偶联物类抗Trop2药物。本文将对Trop2的生物学功能、抗Trop2靶向药在乳腺癌的治疗最新进展等方面进行综述。

Breast cancer is a common malignant tumor with significant heterogeneity. After standard treatment, most patients have a good prognosis, but there are still some breast cancer cases with rapid progression and poor prognosis, especially triple negative breast cancer. Therefore, some new treatment strategies are required. Trophoblast cell surface antigen 2 (Trop2) has a high expression rate in breast cancer and may become a potential therapeutic target. At present, there are some developments in drug research and tumor treatment, and some have been approved for clinical application, especially anti-Trop2 antibody–drug conjugate drugs. This article will review the biological function of Trop2 and the latest progress in the anti-Trop-2 targeted treatment of breast cancer.

1
Siegel RL, Miller KD, Fuchs HE, et al. Cancer statistics, 2022[J]. CA Cancer J Clin, 2022, 72(1):7-33.
2
Ensenyat-Mendez M, Llinàs-Arias P, Orozco J, et al. Current triple-negative breast cancer subtypes: dissecting the most aggressive form of breast cancer [J]. Front Oncol, 2021, 11:681476.
3
Cardoso F, Paluch-Shimon S, Senkus E, et al. 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5) [J]. Ann Oncol, 2020, 31(12):1623-1649.
4
Zeichner SB, Terawaki H, Gogineni K. A review of systemic treatment in metastatic triple-negative breast cancer [J]. Breast Cancer (Auckl), 2016, 10:25-36.
5
Vidula N, Ellisen LW, Bardia A. Novel agents for metastatic triple-negative breast cancer: finding the positive in the negative [J]. J Natl Compr Canc Netw, 2020:1-9.
6
Khosravi-Shahi P, Cabezón-Gutiérrez L, Custodio-Cabello S. Metastatic triple negative breast cancer: Optimizing treatment options, new and emerging targeted therapies [J]. Asia Pac J Clin Oncol, 2018, 14(1):32-39.
7
Cubas R, Li M, Chen C, et al. Trop2: a possible therapeutic target for late stage epithelial carcinomas [J]. Biochim Biophys Acta, 2009, 1796(2):309-314.
8
Goldenberg DM, Stein R, Sharkey RM. The emergence of trophoblast cell-surface antigen 2 (TROP-2) as a novel cancer target [J]. Oncotarget, 2018, 9(48):28989-29006.
9
Shvartsur A, Bonavida B. Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications [J]. Genes Cancer, 2015, 6(3-4):84-105.
10
Guerra E, Trerotola M, Aloisi AL, et al. The Trop-2 signalling network in cancer growth [J]. Oncogene, 2013, 32(12):1594-1600.
11
Lin H, Zhang H, Wang J, et al. A novel human Fab antibody for Trop2 inhibits breast cancer growth in vitro and in vivo [J]. Int J Cancer, 2014, 134(5):1239-1249.
12
Cortesi M, Zanoni M, Maltoni R, et al. TROP2 (trophoblast cell-surface antigen 2): a drug target for breast cancer [J]. Expert Opin Ther Targets, 2022, 26(7):593-602.
13
Zaman S, Jadid H, Denson AC, et al. Targeting Trop-2 in solid tumors: future prospects [J]. Onco Targets Ther, 2019, 12:1781-1790.
14
Zeng P, Chen MB, Zhou LN, et al. Impact of TROP2 expression on prognosis in solid tumors: A Systematic Review and Meta-analysis [J]. Sci Rep, 2016, 6:33658.
15
Trerotola M, Cantanelli P, Guerra E, et al. Upregulation of Trop-2 quantitatively stimulates human cancer growth [J]. Oncogene, 2013, 32(2):222-233.
16
Gaber A, Kim SJ, Kaake RM, et al. EpCAM homo-oligomerization is not the basis for its role in cell-cell adhesion [J]. Sci Rep, 2018, 8(1):13269.
17
Ripani E, Sacchetti A, Corda D, et al. Human Trop-2 is a tumor-associated calcium signal transducer [J]. Int J Cancer, 1998, 76(5):671-676.
18
Tate JG, Bamford S, Jubb HC, et al. COSMIC: the Catalogue Of Somatic Mutations In Cancer [J]. Nucleic Acids Res, 2019, 47(D1):D941-D947.
19
Ambrogi F, Fornili M, Boracchi P, et al. Trop-2 is a determinant of breast cancer survival [J]. PLoS One, 2014, 9(5):e96993.
20
Lenárt S, Lenárt P, Šmarda J, et al. Trop2: Jack of All Trades, Master of None [J]. Cancers (Basel), 2020, 12(11)
21
Liu T, Liu Y, Bao X, et al. Overexpression of TROP2 predicts poor prognosis of patients with cervical cancer and promotes the proliferation and invasion of cervical cancer cells by regulating ERK signaling pathway [J]. PLoS One, 2013, 8(9):e75864.
22
Stoyanova T, Goldstein AS, Cai H, et al. Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling [J]. Genes Dev, 2012, 26(20):2271-2285.
23
Aslan M, Hsu EC, Garcia-Marques FJ, et al. Oncogene-mediated metabolic gene signature predicts breast cancer outcome [J]. NPJ Breast Cancer, 2021, 7(1):141.
24
Pak MG, Shin DH, Lee CH, et al. Significance of EpCAM and TROP2 expression in non-small cell lung cancer [J]. World J Surg Oncol, 2012, 10:53.
25
Hsu EC, Rice MA, Bermudez A, et al. Trop2 is a driver of metastatic prostate cancer with neuroendocrine phenotype via PARP1 [J]. Proc Natl Acad Sci U S A, 2020, 117(4):2032-2042.
26
Zhao W, Jia L, Kuai X, et al. The role and molecular mechanism of Trop2 induced epithelial-mesenchymal transition through mediated β-catenin in gastric cancer [J]. Cancer Med, 2019, 8(3):1135-1147.
27
Lipinski M, Parks DR, Rouse RV, et al. Human trophoblast cell-surface antigens defined by monoclonal antibodies [J]. Proc Natl Acad Sci U S A, 1981, 78(8):5147-5150.
28
Remšík J, Binó L, Kahounová Z, et al. Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition [J]. Carcinogenesis, 2018, 39(11):1411-1418.
29
Xie J, Mølck C, Paquet-Fifield S, et al. High expression of TROP2 characterizes different cell subpopulations in androgen-sensitive and androgen-independent prostate cancer cells [J]. Oncotarget, 2016, 7(28):44492-44504.
30
Cardillo TM, Govindan SV, Sharkey RM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys [J]. Clin Cancer Res, 2011, 17(10):3157-3169.
31
Goldenberg DM, Cardillo TM, Govindan SV, et al. Correction: Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC) [J]. Oncotarget, 2020, 11(10):942.
32
Bardia A, Messersmith WA, Kio EA, et al. Sacituzumab govitecan, a Trop-2-directed antibody-drug conjugate, for patients with epithelial cancer: final safety and efficacy results from the phase Ⅰ/Ⅱ IMMU-132-01 basket trial [J]. Ann Oncol, 2021, 32(6):746-756.
33
Bardia A, Mayer IA, Vahdat LT, et al. Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer [J]. N Engl J Med, 2019, 380(8):741-751.
34
Rugo HS, Bardia A, Marmé F, et al. Sacituzumab govitecan in hormone receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer [J]. J Clin Oncol, 2022, 40(29):3365-3376.
35
Rugo HS, Bardia A, Marmé F, et al. Primary results from TROPiCS-02: A randomized phase 3 study of sacituzumab govitecan (SG) versus treatment of physician's choice (TPC) in patients (Pts) with hormone receptor-positive/HER2-negative (HR+/HER2-) advanced breast cancer [J]. J Clin Oncol, 2022, 40 (suppl 17): abstr LBA1001.
36
Okajima D, Yasuda S, Maejima T, et al. Datopotamab deruxtecan, a novel TROP2-directed antibody-drug conjugate, demonstrates potent antitumor activity by efficient drug delivery to tumor cells [J]. Mol Cancer Ther, 2021, 20(12):2329-2340.
37
Mangino G, Grazia Capri M, Barnaba V, et al. Presentation of native TROP-2 tumor antigens to human cytotoxic T lymphocytes by engineered antigen-presenting cells [J]. Int J Cancer, 2002, 101(4):353-359.
38
Liu H, Bai L, Huang L, et al. Bispecific antibody targeting TROP2xCD3 suppresses tumor growth of triple negative breast cancer [J]. J Immunother Cancer, 2021, 9(10)
39
Ogitani Y, Aida T, Hagihara K, et al. DS-8201a, A novel HER2-targeting ADC with a novel DNA topoisomerase i inhibitor, demonstrates a promising antitumor efficacy with differentiation from T-DM1 [J]. Clin Cancer Res, 2016, 22(20):5097-5108.
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