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中华临床医师杂志(电子版) ›› 2024, Vol. 18 ›› Issue (03) : 309 -314. doi: 10.3877/cma.j.issn.1674-0785.2024.03.012

综述

TGF-β在放射治疗中的双重调控作用
郑鑫蓥1, 张惠勇1, 黄星1, 邱磊1, 方庆亮2, 鹿振辉1, 王蕾2,()   
  1. 1. 200030 上海,上海中医药大学附属龙华医院呼吸疾病研究所
    2. 200030 上海,上海中医药大学附属龙华医院放射治疗科
  • 收稿日期:2023-12-06 出版日期:2024-03-15
  • 通信作者: 王蕾
  • 基金资助:
    上海市自然科学基金项目(23ZR1463900); 上海市卫生行业临床专项(20214Y0377); 上海市医学创新研究专项(21Y11922400)

Dual regulatory role of TGF-β in radiaotherapy

Xinying Zheng1, Huiyong Zhang1, Xing Huang1, Lei Qiu1, Qingliang Fang2, Zhenhui Lu1, Lei Wang2,()   

  1. 1. Institute of Respiratory Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China
    2. Department of Radiation Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China
  • Received:2023-12-06 Published:2024-03-15
  • Corresponding author: Lei Wang
引用本文:

郑鑫蓥, 张惠勇, 黄星, 邱磊, 方庆亮, 鹿振辉, 王蕾. TGF-β在放射治疗中的双重调控作用[J]. 中华临床医师杂志(电子版), 2024, 18(03): 309-314.

Xinying Zheng, Huiyong Zhang, Xing Huang, Lei Qiu, Qingliang Fang, Zhenhui Lu, Lei Wang. Dual regulatory role of TGF-β in radiaotherapy[J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(03): 309-314.

放射治疗通过高能射线的电离辐射作用杀死癌细胞治疗肿瘤。转化生长因子-β(transforming growth factor beta,TGF-β)在受辐照的组织中表达增加,通过减轻放射敏感性和逆转辐射抗性发挥双重调节作用,并参与肿瘤微环境促进上皮细胞-间充质转化,诱导肿瘤细胞免疫逃逸和正常组织放射性纤维化。本文对TGF-β在放射治疗中的作用进行探讨,以期为放疗提供一定的理论依据。

Radiotherapy exerts therapeutic effects on tumors by killing cancer cells through the ionizing radiation effect of high-energy rays. Transforming growth factor-beta (TGF-β), whose expression is increased in irradiated tissues, plays a dual regulatory role by decreasing radiosensitivity and reversing radiation resistance. TGF-β also has a role in the tumor microenvironment to promote epithelial-mesenchymal transition, and induce immune escape of tumor cells and radiofibrosis in normal tissues. This paper discusses the dual role of TGF-β in radiotherapy, aiming to provide a theoretical basis for radiotherapy.

表1 药物联合放疗的临床应用举例
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