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中华临床医师杂志(电子版) ›› 2024, Vol. 18 ›› Issue (08) : 783 -786. doi: 10.3877/cma.j.issn.1674-0785.2024.08.013

综述

小细胞骨肉瘤诊断及治疗研究现状与进展
谭瑞义1,()   
  1. 1.100044 北京,北京大学人民医院
  • 收稿日期:2024-08-12 出版日期:2024-08-15
  • 通信作者: 谭瑞义

Current advances and developments in diagnosis and treatment of small cell osteosarcoma

Ruiyi Tan1,()   

  1. 1.Peking University People's Hospital, Beijing 100044, China
  • Received:2024-08-12 Published:2024-08-15
  • Corresponding author: Ruiyi Tan
引用本文:

谭瑞义. 小细胞骨肉瘤诊断及治疗研究现状与进展[J]. 中华临床医师杂志(电子版), 2024, 18(08): 783-786.

Ruiyi Tan. Current advances and developments in diagnosis and treatment of small cell osteosarcoma[J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(08): 783-786.

小细胞骨肉瘤是骨肉瘤的一个罕见的亚型,预后较差,组织病理学上与其他骨小细胞恶性肿瘤难以鉴别,尤其是Ewing’s 肉瘤,两者免疫组化非常相似,局部穿刺或活检取不到肿瘤性成骨时就不能明确诊断,从而影响下一步治疗方案,因此对小细胞骨肉瘤术前明确诊断具有重要意义。本文结合临床表现特征、影像学特征、病理学特征、治疗及预后对小细胞骨肉瘤做简要综述。

Small cell osteosarcoma is a rare subtype of osteosarcoma with a poor prognosis.It is difficult to differentiate small cell osteosarcoma histopathologically from other malignant bone small cell tumors, especially Ewing’s sarcoma, due to their very similar immunohistochemical features.A diagnosis cannot be made by local puncture or biopsy when no tumor-affected bone is obtained, which affects the treatment plan.Therefore, it is of great significance to make a definite diagnosis of small cell osteosarcoma before surgery.This article briefly reviews the clinical, imaging, pathological, therapeutic, and prognostic features of small cell osteosarcoma.

1
Sim FH, Unni KK, Beabout JW, et al.Osteosarcoma with small cells simulating Ewing's tumor [J].J Bone Joint Surg Am, 1979, 61(2):207-215.
2
Nakajima H, Sim FH, Bond JR, et al.Small cell osteosarcoma of bone:Review of 72 cases[J].Cancer, 1997, 79(11): 2095-2106.
3
蒋智铭, 黄文涛, 张惠箴.小细胞性骨肉瘤14 例临床病理分析 [J].临床与实验病理学杂志, 2012, 28(6): 643-646.
4
Hiemcke-Jiwa LS, Sumathi VP, Baumhoer D, et al.Small cell osteosarcoma versus fusion-driven round cell sarcomas of bone:retrospective clinical, radiological, pathological, and (epi)genetic comparison with clinical implications [J].Virchows Arch, 2024,484(3): 451-463.
5
Righi A, Gambarotti M, Longo S, et al.Small cell osteosarcoma:clinicopathologic, immunohistochemical, and molecular analysis of 36 cases [J].Am J Surg Pathol, 2015, 39(5): 691-699.
6
Bishop JA, Shum CH, Sheth S, et al.Small cell osteosarcoma:cytopathologic characteristics and differential diagnosis [J].Am J Clin Pathol, 2010, 133(5): 756-761.
7
刘丽丽, 沈丹华.小细胞骨肉瘤16 例临床病理特征 [J].临床与实验病理学杂志, 2021, 37(7): 830-832.
8
Kilpatrick SE, Reith JD, Rubin B.Ewing sarcoma and the history of similar and possibly related small round cell tumors: From whence have we come and where are we going? [J].Adv Anat Pathol, 2018,25(5): 314-326.
9
Balamuth NJ, Womer RB.Ewing’s sarcoma [J].Lancet Oncol, 2010,11(2): 184-192.
10
Zhong J, Hu Y, Si L, et al.Clarifying prognostic factors of small cell osteosarcoma: A pooled analysis of 20 cases and the literature [J].J Bone Oncol, 2020, 24: 100305.
11
Klein MJ, Siegal GP.Osteosarcoma: anatomic and histologic variants[J].Am J Clin Pathol, 2006, 125(4): 555-581.
12
Yarmish G, Klein MJ, Landa J, et al.Imaging characteristics of primary osteosarcoma: nonconventional subtypes [J].Radiographics,2010, 30(6): 1653-1672.
13
Nair N.Bone scanning in Ewing's sarcoma [J].J Nucl Med, 1985,26(4): 349-352.
14
Rossleigh MA, Smith J, Yeh SD.Scintigraphic features of primary sacral tumors [J].J Nucl Med, 1986, 27(5): 627-630.
15
Muckle M, Habibi E, Simon B, et al.Appearance of extraosseous pelvic Ewing sarcoma on triphasic bone scan [J].Clin Nucl Med,2014, 39(4): 406-408.
16
Newman EN, Jones RL, Hawkins DS.An evaluation of [F-18]-fluorodeoxy-D-glucose positron emission tomography, bone scan,and bone marrow aspiration/biopsy as staging investigations in Ewing sarcoma [J].Pediatr Blood Cancer, 2013, 60(7): 1113-1117.
17
Byun BH, Kong CB, Lim I, et al.Comparison of (18)F-FDG PET/CT and (99 m)Tc-MDP bone scintigraphy for detection of bone metastasis in osteosarcoma [J].Skeletal Radiol, 2013, 42(12): 1673-1681.
18
Vriens D, Arens AI, de Rooy JW, et al.Hardware failure: a potential pitfall in assessing recurrent Ewing's sarcoma on bone scintigraphy [J].Clin Nucl Med, 2010, 35(6): 430-433.
19
Ulaner GA, Magnan H, Healey JH, et al.Is methylene diphosphonate bone scan necessary for initial staging of Ewing sarcoma if 18F-FDG PET/CT is performed?[J].AJR Am J Roentgenol, 2014, 202(4): 859-867.
20
Alves CRR, Faria DP, Carneiro CG, et al.18F-Fluoride PET/CT and 99mTc-MDP SPECT/CT can detect bone cancer at early stage in rodents [J].Life Sci, 2018, 206: 29-34.
21
Iarŭmov N, Vasilev N, Petkov K.Osteosarkoma na opashnata kost[Osteosarcoma of the coccyx] [J].Khirurgiia (Sofiia), 1997, 50(4): 55-56.
22
Padwal J, Baratto L, Chakraborty A, et al.PET/MR of pediatric bone tumors: what the radiologist needs to know [J].Skeletal Radiol, 2023,52(3): 315-328.
23
Schäfer JF, Gatidis S, Schmidt H, et al.Simultaneous whole-body PET/MR imaging in comparison to PET/CT in pediatric oncology:initial results [J].Radiology, 2014, 273(1): 220-231.
24
丁宜, 席越, 孙晓琪, 等.骨小细胞恶性肿瘤套针穿刺活检与术后病理诊断比较 [J].中华病理学杂志, 2013, 42(3): 163-167.
25
Ayala AG, Ro JY, Raymond AK, et al.Small cell osteosarcoma.A clinicopathologic study of 27 cases [J].Cancer, 1989, 64(10): 2162-2173.
26
Machado I, Alberghini M, Giner F, et al.Histopathological characterization of small cell osteosarcoma with immunohistochemistry and molecular genetic support.A study of 10 cases [J].Histopathology, 2010, 57(1):162-167.
27
Dragoescu E, Jackson-Cook C, Domson G, et al.Small cell osteosarcoma with Ewing sarcoma breakpoint region 1 gene rearrangement detected by interphase fluorescence in situ hybridization [J].Ann Diagn Pathol, 2013,17(4): 377-382.
28
Grier HE, Krailo MD, Tarbell NJ, et al.Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone [J].N Engl J Med, 2003,348(8): 694-701.
29
Cidre-Aranaz F, Watson S, Amatruda JF, et al.Small round cell sarcomas [J].Nat Rev Dis Primers, 2022, 8(1): 66.
30
Amer HW, Algadi HH, Hamza SA.Mandibular small cell osteosarcoma: a case report and review of literature [J].J Egypt Natl Canc Inst, 2023, 35(1): 30.
31
Hingorani P, Zhang W, Zhang Z, et al.Trastuzumab deruxtecan,antibody-drug conjugate targeting HER2, Is effective in pediatric malignancies: A report by the pediatric preclinical testing consortium[J].Mol Cancer Ther, 2022, 21(8): 1318-1325.
32
Shen J, Guo W, Wang J, et al.ALMB-0168, a novel Cx43 hemichannel agonist monoclonal antibody, for metastatic or unresectable osteosarcoma after standard chemotherapy: A multicenter, openlabel, single-arm, phase 1 study [J].J Clin Oncol, 2023, 41(16_suppl):11530-11530.
33
Tang Q, Zhu X, Song G, et al.Camrelizumab in combination with doxorubicin, cisplatin, ifosfamide, and methotrexate as neoadjuvant therapy for osteosarcoma: A single-arm, exploratory phase II trial [J].J Clin Oncol, 2023, 41(16_suppl): 11526-11526.
34
Attia S, Bolejack V, Ganjoo KN, et al.A phase II trial of regorafenib in patients with advanced Ewing sarcoma and related tumors of soft tissue and bone: SARC024 trial results [J].Cancer Med, 2023, 12(2):1532-1539.
35
Mirabello L, Troisi RJ, Savage SA.Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance,Epidemiology, and End Results Program [J].Cancer, 2009, 115(7):1531-1543.
36
Duchman KR, Gao Y, Miller BJ.Prognostic factors for survival in patients with Ewing's sarcoma using the surveillance, epidemiology,and end results (SEER) program database [J].Cancer Epidemiol, 2015,39(2): 189-195.
37
Bielack SS, Kempf-Bielack B, Delling G, et al.Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols [J].J Clin Oncol, 2002, 20(3): 776-790.
38
Bacci G, Longhi A, Ferrari S, et al.Prognostic significance of serum lactate dehydrogenase in osteosarcoma of the extremity: experience at Rizzoli on 1421 patients treated over the last 30 years [J].Tumori,2004, 90(5): 478-484.
39
Bacci G, Longhi A, Versari M, et al.Prognostic factors for osteosarcoma of the extremity treated with neoadjuvant chemotherapy:15-year experience in 789 patients treated at a single institution [J].Cancer, 2006, 106(5): 1154-1161.
40
Fu Y, Lan T, Cai H, et al.Meta-analysis of serum lactate dehydrogenase and prognosis for osteosarcoma [J].Medicine (Baltimore), 2018, 97(19):e0741.
41
Kelley LM, Schlegel M, Hecker-Nolting S, et al.Pathological fracture and prognosis of high-grade osteosarcoma of the extremities: An analysis of 2,847 consecutive cooperative osteosarcoma study group(COSS) patients [J].J Clin Oncol, 2020, 38(8): 823-833.
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