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中华临床医师杂志(电子版) ›› 2024, Vol. 18 ›› Issue (09) : 871 -874. doi: 10.3877/cma.j.issn.1674-0785.2024.09.013

所属专题: 经典病例

病例报告

甲状腺良性结节消融术后复发伴DICER1 基因突变一例及文献复习
姜露露1,2, 徐成成3, 高力4, 朱江1,()   
  1. 1.310006 杭州,浙江大学医学院附属妇产科医院超声科
    2.324000 浙江衢州,温州医科大学附属衢州医院(衢州市人民医院)超声医学科
    3.324100 浙江江山,浙江省江山市人民医院超声科
    4.310016 杭州,浙江大学医学院附属邵逸夫医院头颈外科
  • 收稿日期:2024-08-05 出版日期:2024-09-15
  • 通信作者: 朱江
  • 基金资助:
    国家自然科学基金(82272004)浙江省自然科学基金(LZ22H180001)

DICER1 gene mutation detected in regenerated nodules after ablation of benign thyroid nodules:A case report andliterature review

Lulu Jiang, Chengcheng Xu, Li Gao, Jiang Zhu()   

  • Received:2024-08-05 Published:2024-09-15
  • Corresponding author: Jiang Zhu
引用本文:

姜露露, 徐成成, 高力, 朱江. 甲状腺良性结节消融术后复发伴DICER1 基因突变一例及文献复习[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 871-874.

Lulu Jiang, Chengcheng Xu, Li Gao, Jiang Zhu. DICER1 gene mutation detected in regenerated nodules after ablation of benign thyroid nodules:A case report andliterature review[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(09): 871-874.

图1 2018 年左侧甲状腺结节超声成像:甲状腺左侧叶几乎被囊性实性结节(59.3 mm*35.8mm*53.6 mm)取代,实性部分呈等回声,实性部分内血流丰富,囊性部分不规则(约40.3 mm*20.4 mm)。图a 和b 为甲状腺左叶几乎被囊性实性结节所取代;图c 为实性部分呈均匀细密等回声,结节内实性部分血流较丰富;图d 为囊性部分囊壁欠规则
图2 RFA 术前、术后超声造影图像。图a 为RFA 术前超声造影:甲状腺左叶结节呈高灌注;图b 为RFA 术后即刻超声造影:甲状腺左叶结节无造影剂填充 注:RFA 为射频消融
图3 RFA 术后3 个月左侧甲状腺结节超声成像。图a~c 为甲状腺左叶巨大结节部分消融术后(结节大小约49.4 mm*28.3 mm*42.2 mm),消融部分内部未见明显血流信号,未消融部分内部见血流信号(消融术前容积约72.77 ml,现容积约30.67 ml,结节缩小率约57.9%) 注:RFA 为射频消融
图4 RFA 术后20 个月左侧甲状腺结节超声成像。图a 和b 为甲状腺左叶内见一大小65.0 mm*30.5 mm*49.6 mm 囊实性结节,以实性为主,边界清,形态规则;图c 为结节中央为范围约26.0 mm*18.1 mm 的不均质偏低回声,为射频术后改变,周边呈细密等回声;图d 为结节偏低回声区无明显血流信号,等回声部分血流信号丰富 注:RFA 为射频消融
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