切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2024, Vol. 18 ›› Issue (11) : 1070 -1074. doi: 10.3877/cma.j.issn.1674-0785.2024.11.015

病例报告

罕见并发于肾脏透明细胞癌的抗Yo 抗体阳性的副肿瘤性小脑变性一例及文献复习
贾欢1, 王晓磊2, 李春阳1   
  1. 1.010010 呼和浩特,内蒙古自治区精神卫生中心(内蒙古自治区第三医院 内蒙古自治区脑科医院)神经内一科
    2.010010 呼和浩特,内蒙古医科大学附属医院超声科
  • 收稿日期:2024-09-23 出版日期:2024-11-15
  • 基金资助:
    内蒙古自治区2024 年公立医院科研联合基金科技项目(项目编号:2024GLLH0223 2024GLLH0224)内蒙古自治区卫生健康委2024 临床专科建设科技项目(项目编号:2024SGG2048)

Anti-Yo-associated paraneoplastic cerebellar degeneration complicated with renal clear cell carcinoma: A case report and literature review

Huan Jia, Xiaolei Wang, Chunyang Li   

  • Received:2024-09-23 Published:2024-11-15
引用本文:

贾欢, 王晓磊, 李春阳. 罕见并发于肾脏透明细胞癌的抗Yo 抗体阳性的副肿瘤性小脑变性一例及文献复习[J/OL]. 中华临床医师杂志(电子版), 2024, 18(11): 1070-1074.

Huan Jia, Xiaolei Wang, Chunyang Li. Anti-Yo-associated paraneoplastic cerebellar degeneration complicated with renal clear cell carcinoma: A case report and literature review[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(11): 1070-1074.

图1 患者头颅磁共振平扫结果。图a 轴位像T1 加权序列,图b 轴位像T2 加权序列,图c 轴位像FLAIR 序列双侧侧脑室周围脑白质脱髓鞘,图d 弥散加权序列,图e 矢状位T1 加权像,图f 为磁共振血管成像,右侧部分胚胎型大脑后动脉(正常变异)
图2 患者颈胸腰椎共振平扫。图a 为颈椎T2 加权序列;图b 为胸椎T2 加权序列;图c 为腰椎T2 加权序列;图d 为胸椎6 节段轴位
图3 脑脊液和血清TBA。图a 为血清TBA 检测10X 下荧光抗体沉积;图b 为血清TBA 检测20X 下荧光抗体沉积;图c为脑脊液TBA 检测10X 下荧光抗体沉积;图d 为脑脊液TBA 检测20X 下荧光抗体沉积 注:TBA 为组织免疫荧光法
图4 脑脊液+血清副肿瘤抗体谱14 项。图a 为脑脊液副肿瘤抗体谱;图b 为脑脊液副肿瘤抗体荧光染色;图c 为血清副肿瘤抗体谱;图d 为血清副肿瘤抗体荧光染色 注:Yo 为抗体阳性;脑脊液的起始稀释梯度为1:1,血清的起始稀释梯度为1:10;“+”数量为该稀释度下的荧光强度
图5 腹部增强CT。图a 为全腹CT 平扫;图b 为全腹增强CT 动脉期;图c 为全腹增强CT 静脉期;图d 为全腹增强CT延迟期
1
Anderson NE, Budde-Steffen C, Wiley RG, et al. A variant of the anti-Purkinje cell antibody in a patient with paraneoplastic cerebellar degeneration [J]. Neurlogy, 1988, 38(7): 1018-1026.
2
Guan HZ, Ren HT, Peng B, et al. Anti-Yo antibody-associated paraneoplastic cerebellar degeneration: a report of 6 patients [J]. Chin J Neurol, 2015, 48(2): 89-93.
3
Cuartero IG, Galdeano MR, Pinar MP, et al. Thymic carcinoma associated with cerebellar degeneration[J]. Eur J Case Rep Intern Med,2018, 5(3): 000780.
4
Yan L, Dong X, Xu H, et al. Paraneoplastic cerebellar degeneration associated with breast cancer: a case report and review of the literature[J]. Mol Clin Oncol, 2018, 9(2): 163-167.
5
关鸿志. 自身免疫性小脑共济失调的诊治 [J]. 中华神经志, 2024,57(6): 642-648.
6
Yshii L, Bost C, Liblau R. Immunological bases of paraneoplastic cerebellar degeneration and therapeutic implications [J]. Front Immunol, 2020, 11: 991.
7
Monstad SE, Storstein A, Dørum A, et al.Yo antibodies in ovarian and breast cancer patients detected by a sensitive immunoprecipitation technique [J]. Clin Exp Immunol, 2006, 144(1): 53-58.
8
Hashimoto Y, Komatsu K, Nakagawa T, et al. Transient diffusion-weighted imaging hyperintensity of the cerebellar cortex in paraneoplastic cerebellar degeneration [J]. Intern Med, 2019, 58(4):619-620.
9
Graus F, Vogrig A, MuñizCastrillo S, et al. Updated diagnostic criteria for paraneoplastic neurologic syndromes [J]. Neurol Neuroimmunol Neuroinflamm, 2021, 8(4): e1014.
10
Hens MJ, Camacho B, Maestre A, et al. Carcinoma renal que debuta como cuadro neurológico paraneoplásico [J]. Actas Urol Esp, 2008,32(6): 645-648.
11
Souza SM, Santos BO, Sodré ICA, et al. Paraneoplastic cerebellar degeneration as initial presentation of renal cell carcinoma [J].Cerebellum Ataxias, 2019, 6(1):1-3.
12
Shams'ili S, Grefkens J, de Leeuw B, et al. Paraneoplasticcerebellar degeneration associated with antineuronal antibodies: analysis of 50 patients [J]. Brain, 2003, 126(6): 1409-1418.
13
高君伟, 刘皋林. 自身免疫性疾病的药物治疗 [J/OL]. 中华临床医师杂志(电子版), 2023, 17(12): 1209-1211.
14
Zhou Q, Yin D, Ma J, et al. The therapeutic effect of ofatumumab in autoimmune encephalitis: A case series [J]. J Neuroimmunol, 2023,377: 578062.
15
Yeo KK, Walter AW, Miller RE, et al. Rituximab as potentialtherapy for paraneoplastie cerebellar degeneration in pediatricHodgkin disease[J]. Pediatr Blood Cancer, 2012, 58(6): 986-987.
No related articles found!
阅读次数
全文


摘要