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中华临床医师杂志(电子版) ›› 2025, Vol. 19 ›› Issue (07) : 532 -535. doi: 10.3877/cma.j.issn.1674-0785.2025.07.008

综述

EphA2在胃癌发病机制和治疗中的研究进展
刘月胜, 苑宇航, 武艺峰, 袁虎方()   
  1. 050000 石家庄,河北医科大学第四医院外三科
  • 收稿日期:2025-07-30 出版日期:2025-07-30
  • 通信作者: 袁虎方

Role of EphA2 in the pathogenesis and treatment of gastric cancer

Yuesheng Liu, Yuhang Yuan, Yifeng Wu, Hufang Yuan()   

  1. Third Department of General Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China
  • Received:2025-07-30 Published:2025-07-30
  • Corresponding author: Hufang Yuan
引用本文:

刘月胜, 苑宇航, 武艺峰, 袁虎方. EphA2在胃癌发病机制和治疗中的研究进展[J/OL]. 中华临床医师杂志(电子版), 2025, 19(07): 532-535.

Yuesheng Liu, Yuhang Yuan, Yifeng Wu, Hufang Yuan. Role of EphA2 in the pathogenesis and treatment of gastric cancer[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2025, 19(07): 532-535.

胃癌是全球常见的恶性肿瘤之一,以恶性程度高和预后差为特点。近年来,肿瘤的免疫靶向治疗成为热点,越来越多的生物学靶点被发现。促红细胞生成素诱导肝细胞受体A2(EphA2)是一种受体酪氨酸激酶,参与胃癌细胞的增殖、侵袭和转移过程,有研究发现,其高表达与肿瘤的发展、转移和预后密切相关。这篇文章将讨论EphA2在胃癌发病机制中的研究进展和治疗中的前景展望。

Gastric cancer is one of the most common malignant tumors in the world, characterized by a high degree of malignancy and poor prognosis. In recent years, immunotargeted therapy for tumors has become a hot research topic, and more and more biological targets have been discovered. Erythropoietin-induced hepatocyte receptor A2 (EphA2) is a receptor tyrosine kinase involved in the proliferation, invasion, and metastasis of gastric cancer cells. This article reviews the role of EphA2 in the pathogenesis of gastric cancer and its therapeutic potential.

1
Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249.
2
Xia C, Dong X, Li H, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants[J]. Chin Med J (Engl), 2022, 135(5): 584-590.
3
Yoshida N, Doyama H, Yano T, et al. Early gastric cancer detection in high-risk patients: a multicentre randomised controlled trial on the effect of second-generation narrow band imaging[J]. Gut, 2021, 70(1): 67-75.
4
Eusebi LH, Telese A, Marasco G, et al. Gastric cancer prevention strategies: A global perspective[J]. J Gastroenterol Hepatol, 2020, 35(9): 1495-1502.
5
Wei C, Du X, Hu J, et al. Perioperative chemotherapy versus adjuvant chemotherapy in patients with resectable gastric cancer: A systematic review with meta-analysis[J]. Crit Rev Oncol Hematol, 2023, 31: 104082.
6
Xiao T, Xiao Y, Wang W, et al. Targeting EphA2 in cancer[J]. J Hematol Oncol, 2020, 13(1): 114.
7
Tomiyama E, Fujita K, Matsuzaki, et al. EphA2 on urinary extracellular vesicles as a novel biomarker for bladder cancer diagnosis and its effect on the invasiveness of bladder cancer [J]. Br J Cancer, 2022, 127, 1312-1323.
8
Kim J, Chang IY, You HJ. Interactions between EGFR and EphA2 promote tumorigenesis through the action of Ephexin1[J]. Cell Death Dis, 2022, 13(6): 528.
9
Harris ED, Sharpe JC, Strozen T, et al. The EphA2 receptor regulates invasiveness and drug sensitivity in canine and human osteosarcoma cells[J]. Cells, 2024, 13(14): 1201.
10
Zhou Y, Sakurai H. Emerging and diverse functions of the EphA2 noncanonical pathway in cancer progression[J]. Biol Pharm Bull, 2017, 40(10): 1616-1624.
11
Li Y, Hu Y, Zhan X, et al. Meta-analysis reveals Helicobacter pylori mutual exclusivity and reproducible gastric microbiome alterations during gastric carcinoma progression[J]. Gut Microbes, 2023, 15(1): 2197835.
12
Leite M, Marques MS, Melo J, et al. Helicobacter Pylori targets the EPHA2 Receptor tyrosine kinase in gastric cells modulating key cellular functions[J]. Cells, 2020, 9(2): 513.
13
Hirabayashi M, Georges D, Clifford GM, et al. Estimating the global burden of epstein-barr virus-associated gastric cancer: A systematic review and meta-analysis[J]. Clin Gastroenterol Hepatol, 2023, 21(4): 922-930.e21.
14
Fekadu S, Kanehiro Y, Kartika AV, et al. Gastric epithelial attachment of helicobacter pylori induces EphA2 and NMHC-IIA receptors for epstein-barr virus[J]. Cancer Sci, 2021, 112(11): 4799-4811.
15
Shi D, Liu W, Zhang X, et al. MiR-BART1-3p and BART18-5p inhibit cell migration, proliferation and activate autophagy in Epstein-Barr virus-associated gastric cancer by targeting erythropoietin-producing human hepatocellular 2[J]. Virus Genes, 2023, 59(5): 703-715.
16
Ren HY, Shen JX, Mao XM, et al. Correlation between tumor vasculogenic mimicry and poor prognosis of human digestive cancer patients: A systematic review and meta-analysis[J]. Pathol Oncol Res, 2019, 25(3): 849-858.
17
Kim HS, Won YJ, Shim JH, et al. Role of EphA2-PI3K signaling in vasculogenic mimicry induced by cancer-associated fibroblasts in gastric cancer cells[J]. Oncol Lett, 2019, 18(3): 3031-3038.
18
Kim HS, Won YJ, Shim JH, et al. Morphological characteristics of vasculogenic mimicry and its correlation with EphA2 expression in gastric adenocarcinoma[J]. Sci Rep, 2019, 9(1): 3414.
19
Hong HN, Won YJ, Shim JH, et al. Cancer-associated fibroblasts promote gastric tumorigenesis through EphA2 activation in a ligand-independent manner[J]. J Cancer Res Clin Oncol, 2018, 144(9): 1649-1663.
20
Zhou Y, Oki R, Tanaka A, et al. Cellular stress induces non-canonical activation of the receptor tyrosine kinase EphA2 through the p38-MK2-RSK signaling pathway[J]. J Biol Chem, 2023, 299(5): 104699.
21
Han J, Wang L, Lv H, et al. EphA2 inhibits SRA01/04 cells apoptosis by suppressing autophagy via activating PI3K/Akt/mTOR pathway[J]. Arch Biochem Biophys, 2021, 711: 109024.
22
Mao L, Yuan W, Cai K, et al. EphA2-YES1-ANXA2 pathway promotes gastric cancer progression and metastasis[J]. Oncogene, 2021, 40(20): 3610-3623.
23
Peng Q, Chen L, Wu W, et al. EPH receptor A2 governs a feedback loop that activates Wnt/β-catenin signaling in gastric cancer[J]. Cell Death Dis, 2018, 9(12): 1146.
24
Huang C, Yuan W, Lai C, et al. EphA2-to-YAP pathway drives gastric cancer growth and therapy resistance[J]. Int J Cancer, 2020, 146(7): 1937-1949.
25
Wang F, Zhang H, Cheng Z. EPHA2 promotes the invasion and migration of human tongue squamous cell carcinoma Cal-27 cells by enhancing AKT/mTOR signaling pathway[J]. Biomed Res Int, 2021, 2021: 4219690.
26
Wang DH, Zhang YJ, Zhang SB, et al. Geldanamycin mediates the apoptosis of gastric carcinoma cells through inhibition of EphA2 protein expression[J]. Oncol Rep, 2014, 32(6): 2429-2436.
27
Lee H, Lee J, Sohn I, et al. To excavate biomarkers predictive of the response for capecitabine plus RAD001 through nanostring-based multigene assay in advanced gastric cancer patients[J]. J Cancer, 2016, 7(15): 2173-2178.
28
Wen Q, Chen Z, Chen Z, et al. EphA2 affects the sensitivity of oxaliplatin by inducing EMT in oxaliplatin-resistant gastric cancer cells[J]. Oncotarget, 2017, 8(29): 47998-48011.
29
Chen Z, Liu Z, Gao J, et al. EPHA2/MAPK pathway confers acquired resistance of afatinib in gastric cancer ANN ONCOL[J]. ANN ONCOL, 2018, 29.
30
Lee PC, Chen ST, Kuo TC, et al. C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer[J]. Oncogene, 2020, 39(13): 2724-2740.
31
Huang J, He Y, Mcleod HL, et al. miR-302b inhibits tumorigenesis by targeting EphA2 via Wnt/ β-catenin/EMT signaling cascade in gastric cancer[J]. BMC Cancer, 2017, 17(1): 886.
32
Song B, Lin HX, Dong LL, et al. MicroRNA-338 inhibits proliferation, migration, and invasion of gastric cancer cells by the Wnt/β-catenin signaling pathway[J]. Eur Rev Med Pharmacol Sci, 2018, 22(5): 1290-1296.
33
Li R, Hu Z, Wang Z, et al. miR-125a-5p promotes gastric cancer growth and invasion by regulating the Hippo pathway[J]. J Clin Lab Anal, 2021, 35(12): e24078.
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