鉴于“X疾病”对全球公共卫生造成的严重威胁及传统疫情管理模式的不足，本研究探索了北京某大型公立综合三甲医院对X疾病的精准防控策略与实施路径。研究以风险管理理论和医院韧性理论为基础，以最小诊疗单元为切入点，提出“一科一策”的个性化感染防控等级分区管理模式，明确应急分区管控的启动依据、应急风险区域划分与管控标准、感染防控操作规范及人员转运策略。通过构建“院区-科室-病房”三级防控网络与“红-黄-绿”三区防控模式，结合“文字规范+流程图示”的可视化指引，实现精准化与差异化防控目标。本研究为大型综合医院X疾病精准防控提供了切实可行的实践路径，为推动传染病精准防控提供了实践价值。

In light of the significant threat posed by Disease X to global public health and the shortcomings of traditional epidemic management models, this study examines precise prevention and control strategies along with implementation pathways for Disease X in large general hospitals. Grounded in risk management and hospital resilience theories, this study focuses on the smallest medical treatment unit as the entry point. It proposes a personalized hierarchical zoning management model for infection prevention and control based on the principle of "one department, one strategy", clarifies the rationale for initiating hierarchical containment, defines the criteria for designating and managing emergency risk zones, specifies operational protocols for infection prevention and control, and formulates strategies for personnel deployment. By developing a "hospital campus-department-ward" tri-zone prevention and control network and a "red-yellow-green" three-tier risk management model, supplemented by visual guidance in the form of "textual specifications + process diagrams", this study achieves precise and differentiated disease prevention and control. The framework offers a practical and viable implementation pathway for the precise prevention and control of Disease X in large general hospitals, providing valuable insights for advancing precise prevention and control of infectious diseases.