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中华临床医师杂志(电子版) ›› 2018, Vol. 12 ›› Issue (07) : 405 -409. doi: 10.3877/cma.j.issn.1674-0785.2018.07.007

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综述

靶向Th17细胞免疫治疗中重度哮喘的作用
韩露1, 王楠1, 陈子1, 周林福2,†()   
  1. 1. 210029　南京医科大学第一附属医院呼吸与危重症医学科
    2. 210029　南京医科大学第一附属医院呼吸与危重症医学科；210029　南京医科大学中西医结合研究所；215228　南京医科大学附属江苏盛泽医院（江苏省人民医院盛泽分院）呼吸内科
  • 收稿日期:2018-02-20 出版日期:2018-04-01
  • 通信作者: 周林福
  • 基金资助:
    国家重点研发计划(2018YFC1313600); 国家自然科学基金(81820108001、81670029、81370133、81170018); 江苏省医学重点人才项目(ZDRCA2016018); 江苏省333高层次人才工程第二层次培养对象(201605); 江苏省社会发展重点研发专项(BE2015651); 江苏省卫生计生委预防医学科研课题(Y2015026); 江苏省中医药科技项目(YB2015110); 苏州市科技计划项目(SYS201402); 江苏省研究生科研创新计划(KYCX171285)

Th17 cells as a potential target for treatment of moderate-to-severe asthma

Lu Han1, Nan Wang1, Zi Chen1, Linfu Zhou2,†()   

  1. 1. Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    2. Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; Institute of Integrative Medicine of Nanjing Medical University, Nanjing 210029, China; Department of Respiratory Medicine, Jiangsu Shengze Hospital, Suzhou 215228, China
  • Received:2018-02-20 Published:2018-04-01
  • Corresponding author: Linfu Zhou
  • About author:
    Corresponding author: Zhou Linfu, Email:
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韩露, 王楠, 陈子, 周林福. 靶向Th17细胞免疫治疗中重度哮喘的作用[J]. 中华临床医师杂志(电子版), 2018, 12(07): 405-409.

Lu Han, Nan Wang, Zi Chen, Linfu Zhou. Th17 cells as a potential target for treatment of moderate-to-severe asthma[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(07): 405-409.

支气管哮喘（简称哮喘）是多种炎症细胞和炎性介质参与的慢性气道炎症性疾病。Thl/Th2免疫反应失衡是哮喘主要的发病机制，而嗜酸粒细胞性气道炎症和气道高反应性为哮喘的显著临床特征。Th17细胞通过活化和募集中性粒细胞，促进气道炎症发生发展，尤其与中重度哮喘密切相关。Th17细胞为中重度哮喘提供了潜在的治疗靶点。深入研究Th17细胞分化调控机制，有望为治疗中性粒细胞性哮喘带来新的愿景。

关键词: 哮喘, 中性粒细胞, Th17细胞, 免疫疗法

Bronchial asthma (asthma) is a chronic inflammatory airway disease involving a variety of inflammatory cells and inflammatory mediators. The imbalance of Thl/Th2 immune responses leads to airway hyperresponsiveness and eosinophilic airway inflammation. However, Th17 cells play a role in the pathophysiology of asthma through the recruitment and activation of neutrophils. Neutrophil infiltration is related to the occurrence of moderate-to-severe asthma. Therefore, Th17 cells may be a potential therapeutic target for asthma, especially moderate-to-severe asthma. Further studies to dissect the molecular mechanism of Th17 cell differentiation will contribute to developing a novel strategy for treatment of neutrophilic asthma.

Key words: Asthma, Neutrophils, Th17 cells, Immunotherapy
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