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中华临床医师杂志(电子版) ›› 2017, Vol. 11 ›› Issue (21) : 2373 -2376. doi: 10.3877/cma.j.issn.1674-0785.2017.21.005

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综述

高糖环境对心血管系统的影响及尼可地尔在心血管疾病中的应用
赵玉青1, 柴颖儒1,(), 江莉1, 安国霞1, 柴晏1   
  1. 1. 030000 太原,山西医科大学第二医院心内科
  • 收稿日期:2017-02-13 出版日期:2017-11-01
  • 通信作者: 柴颖儒

Effect of high glucose on cardiovascular system: application of nicorandil in cardiovascular disease

Yuqing Zhao1, Yingru Chai1,(), Li Jiang1, Guoxia An1, Yan Chai1   

  1. 1. Department of Cardiovascular Medicine, the Second Hospital of Shanxi University, Taiyuan 030000, China
  • Received:2017-02-13 Published:2017-11-01
  • Corresponding author: Yingru Chai
  • About author:
    Corresponding author: Chai Yingru, Email:
引用本文:

赵玉青, 柴颖儒, 江莉, 安国霞, 柴晏. 高糖环境对心血管系统的影响及尼可地尔在心血管疾病中的应用[J]. 中华临床医师杂志(电子版), 2017, 11(21): 2373-2376.

Yuqing Zhao, Yingru Chai, Li Jiang, Guoxia An, Yan Chai. Effect of high glucose on cardiovascular system: application of nicorandil in cardiovascular disease[J]. Chinese Journal of Clinicians(Electronic Edition), 2017, 11(21): 2373-2376.

冠心病严重威胁人类健康,合并糖尿病者更甚。糖尿病可引起大血管、微血管并发症,表现在心血管系统中主要是对血管内皮细胞的损伤,导致或加重动脉粥样硬化症进程,同时还可使心肌细胞凋亡。究其原因近来多研究的为氧化应激、炎症反应、内质网应激等,抗氧化应激、内质网应激,减缓炎症反应至关重要。新型心血管药物尼可地尔可同时起到扩张血管、保护心脏、改善内皮细胞的作用。本研究就高糖环境对心血管系统的影响及尼可地尔在心血管疾病中的应用进行综述。

Coronary heart disease threatens the people's health seriously, especially when it is accompanied with diabetes mellitus. Diabetes mellitus can lead to macroangiopathy and microangiopathy, which manifest as vascular endothelial injury in the cardiovascular system and can lead to or exacerbate the process of atherosclerosis and myocardial apoptosis. Many studies indicate that oxidative stress, inflammatory reaction, and endoplasmic reticulum stress are the probable mechanisms, and therefore antagonizing these factors is of particular significance. Nicorandil, a new cardiovascular drug, plays an important role in vasodilation and cardioprotection and can improve the endothelial function.

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