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中华临床医师杂志(电子版) ›› 2018, Vol. 12 ›› Issue (02) : 111 -114. doi: 10.3877/cma.j.issn.1674-0785.2018.02.011

所属专题: 文献

综述

塌陷性肾小球病研究进展
赵嘉懿1, 张文贤1, 冯杰1, 刘茂东1,()   
  1. 1. 050000 石家庄,河北医科大学第三医院肾内科
  • 收稿日期:2017-09-07 出版日期:2018-01-15
  • 通信作者: 刘茂东

Progress in research of collapsing glomerulopathy

Jiayi Zhao1, Wenxian Zhang1, Jie Feng1, Maodong Liu1,()   

  1. 1. Department of Nephrology, the Third Hospital of Hebei Medical University, Shijiazhuang 050000, China
  • Received:2017-09-07 Published:2018-01-15
  • Corresponding author: Maodong Liu
  • About author:
    Corresponding author: Liu Maodong, Email:
引用本文:

赵嘉懿, 张文贤, 冯杰, 刘茂东. 塌陷性肾小球病研究进展[J]. 中华临床医师杂志(电子版), 2018, 12(02): 111-114.

Jiayi Zhao, Wenxian Zhang, Jie Feng, Maodong Liu. Progress in research of collapsing glomerulopathy[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(02): 111-114.

塌陷性肾小球病(CG)之前被视为局灶节段性肾小球硬化(FSGS)的一个亚型。但病理上CG更多表现为足细胞增生和细胞骨架微丝减少直至毛细血管襻塌陷,由此区别于FSGS(足细胞数目减少和细胞外基质积聚而出现节段性或球性肾小球硬化),且在流行病学和临床表现上CG也都明显区别于FSGS,因此现将其定义为一个新的独立性疾病。

Collapsing glomerulopathy (CG) was ever considered a variant of focal segmental glomerulosclerosis (FSGS). However, in morphology, CG is characterized by podocyte proliferation, microfilament decrease, and capillary loop collapsing, which are different from the features of FSGS (such as podocyte number decrease, extracellular matrix accumulation, and segmental or glomerular sclerosis). CG is also significantly distinguished from FSGS both in epidemiology and clinical manifestations, therefore it is now recognized as a new independent disease.

1
Albaqumi M, Barisoni L. Current views on collapsing glomerulopathy [J]. J Am Soc Nephrol, 2008, 19(7): 1276-1281.
2
Pardo V, Aldana M, Colton RM, et al. Glomerular lesions in the acquired immunodeficiency syndrome [J]. Ann Intern Med, 1984, 101(4): 429-434.
3
Weiss MA, Daquioag E, Margolin EG, et al. Nephrotic syndrome, progressive irreversible renal failure, and glomerular ″collapse″: a new clinicopathologic entity? [J]. Am J Kidney Dis, 1986, 7(1): 20-28.
4
D′Agati VD, Fogo AB, Bruijn JA, et al. Pathologic classification of focal segmental glomerulosclerosis: a working proposal [J]. Am J Kidney Dis, 2004, 43(2):368-382.
5
Barisoni L, Schnaper HW, Kopp JB. A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases [J]. Clin J Am Soc Nephrol, 2007, 2(3): 529-542.
6
福戈(FogoA B)(美), 卡什加里安(Kasharian M)(美). 肾脏病理诊断图谱[M]. 北京: 北京大学医学出版社. 2007: 25-29.
7
梅净,杜晓刚. 系统性红斑狼疮相关性塌陷性肾小球病研究进展 [J]. 重庆医科大学学报, 2016, 41(3): 318-321.
8
Husain S. Collapsing glomerulopathy, the Saudi Arabian scenario. A study of 31 cases and a review of literature [J]. Saudi Med J, 2017, 38(5): 509-516.
9
Raja R, Nada R, Yadav AK, et al. A prospective study of collapsing focal segmental glomerulosclerosis [J]. Ren Fail, 2016, 38(6): 894-898.
10
Barisoni L, Madaio MP, Eraso M, et al. The kd/kd mouse is a model of collapsing glomerulopathy [J]. J Am Soc Nephrol, 2005, 16(10): 2847-2851.
11
Dijkman H, Smeets B, van der Laak J, et al. The parietal epithelial cell is crucially involved in human idiopathic focal segmental glomerulosclerosis [J]. Kidney Int, 2005, 68(4): 1562-1572.
12
Thomas DB, Franceschini N, Hogan SL, et al. Clinical and pathologic characteristics of focal segmental glomerulosclerosis pathologic variants [J]. Kidney Int, 2006, 69(5): 920-926.
13
Albaqumi M, Soos TJ, Barisoni L, et al. Collapsing glomerulopathy [J]. J Am Soc Nephrol, 2006, 17(10): 2854-2863.
14
Kopp JB, Nelson GW, Sampath K, et al. APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy [J]. J Am Soc Nephrol, 2011, 22(11): 2129-2137.
15
Shah PB, Cooper JE, Lucia MS, et al. APOL1 polymorphisms in a deceased donor and early presentation of collapsing glomerulopathy and focal segmental glomerulosclerosis in two recipients [J]. Am J Transplant, 2016, 16(6): 1923-1927.
16
Larsen CP, Freedman BI. Apolipoprotein L1-associated nephropathy and the future of renal diagnostics [J]. J Am Soc Nephrol, 2015, 26(6): 1232-1235.
17
Lan X, Jhaveri A, Cheng K, et al. APOL1 risk variants enhance podocyte necrosis through compromising lysosomal membrane permeability [J]. Am J Physiol Renal Physiol, 2014, 307(3): F326-336.
18
O′Rourke B, Cortassa S, Aon MA. Mitochondrial ion channels: gatekeepers of life and death [J]. Physiology (Bethesda), 2005, 20: 303-315.
19
Ding M, Cui S, Li C, et al. Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice [J]. Nat Med, 2006, 12(9): 1081-1087.
20
Barisoni L, Nelson PJ. Collapsing glomerulopathy: an inflammatory podocytopathy? [J]. Curr Opin Nephrol Hypertens, 2007, 16(3): 192-195.
21
Chandra P, Kopp JB. Viruses and collapsing glomerulopathy: a brief critical review [J]. Clin Kidney J, 2013, 6(1): 1-5.
22
Moudgil A, Nast CC, Bagga A, et al. Association of parvovirus B19 infection with idiopathic collapsing glomerulopathy [J]. Kidney Int, 2001, 59(6): 2126-2133.
23
Freitas GR, Praxedes MR, Malheiros D, et al. Collapsing variant of focal segmental glomerulosclerosis by parvovirus B19: case report [J]. J Bras Nefrol, 2015, 37(1): 121-126.
24
Besse W, Mansour S, Jatwani K, et al. Collapsing glomerulopathy in a young woman with APOL1 risk alleles following acute parvovirus B19 infection: a case report investigation [J]. BMC Nephrol, 2016, 17(1): 125.
25
Kofman T, Narjoz C, Raimbourg Q, et al. Collapsing glomerulopathy associated lupus in a black female with homozygous APOL1 mutation [J]. Lupus, 2012, 21(13): 1459-1462.
26
Larsen CP, Beggs ML, Saeed M, et al. Apolipoprotein L1 risk variants associate with systemic lupus erythematosus-associated collapsing glomerulopathy [J]. J Am Soc Nephrol, 2013, 24(5): 722-725.
27
Nichols B, Jog P, Lee JH, et al. Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1 [J]. Kidney Int, 2015, 87(2): 332-342.
28
Laurinavicius A, Rennke HG. Collapsing glomerulopathy--a new pattern of renal injury [J]. Semin Diagn Pathol, 2002, 19(3): 106-115.
29
Singh N, Rathi M, Nada R, et al. Collapsing glomerulopathy in a case of anti-neutrophil cytoplasmic antibody associated vasculitis [J]. Indian J Nephrol, 2016, 26(2): 138-141.
30
Buob D, Decambron M, Gnemmi V, et al. Collapsing glomerulopathy is common in the setting of thrombotic microangiopathy of the native kidney [J]. Kidney Int, 2016, 90(6): 1321-1331.
31
Kunin M, Kopolovic J, Avigdor A, et al. Collapsing glomerulopathy induced by long-term treatment with standard-dose pamidronate in a myeloma patient [J]. Nephrol Dial Transplant, 2004, 19(3): 723-726.
32
Kanungo S, Tamirisa S, Gopalakrishnan R, et al. Collapsing glomerulopathy as a complication of interferon therapy for hepatitis C infection [J]. Int Urol Nephrol, 2010, 42(1): 219-222.
33
Laurinavicius A, Hurwitz S, Rennke HG. Collapsing glomerulopathy in HIV and non-HIV patients: a clinicopathological and follow-up study [J]. Kidney Int, 1999, 56(6): 2203-2213.
34
Schwimmer JA, Markowitz GS, Valeri A, et al. Collapsing glomerulopathy [J]. Semin Nephrol, 2003, 23(2): 209-218.
35
Mubarak M, Kazi JI. Topics in renal biopsy and pathology[M]. Coratia: InTech, 2012: 139-156.
36
Abadeer K, Alsaad AA, Geiger XJ, et al. Collapsing glomerulopathy in systemic lupus erythematosus [J]. BMJ Case Rep, 2017. pii: bcr2016217840.
37
Canaud G, Zuber J, Sberro R, et al. Intensive and prolonged treatment of focal and segmental glomerulosclerosis recurrence in adult kidney transplant recipients: a pilot study [J]. Am J Transplant, 2009, 9(5): 1081-1086.
38
Sureshkumar KK, Dosani I, Jasnosz KM, et al. De Novo Collapsing Glomerulopathy: An Unusual Cause of Early Graft Failure following Kidney Transplantation [J]. Case Rep Transplant, 2011, 2011: 263970.
39
Vanikar AV, Trivedi HL, Shah PR, et al. Single-center experience on renal transplantation in primary focal and segmental glomerulosclerosis using hematopoietic stem cell transplantation in thymus, bone marrow, portal and peripheral circulation [J]. Saudi J Kidney Dis Transpl, 2013, 24(1): 15-21.
40
Kanodia KV, Vanikar AV, Patel RD, et al. Collapsing glomerulopathy: a single centre clinicopathologic study of seven years [J]. J Clin Diagn Res, 2016, 10(4): EC15-17.
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