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中华临床医师杂志(电子版) ›› 2018, Vol. 12 ›› Issue (02) : 115 -118. doi: 10.3877/cma.j.issn.1674-0785.2018.02.012

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综述

血清肝细胞生长因子水平与非酒精性脂肪性肝病的相关性研究进展
郑晓娟1, 杨斐1, 刘近春1,()   
  1. 1. 030001 太原,山西医科大学第一医院消化内科
  • 收稿日期:2017-07-05 出版日期:2018-01-15
  • 通信作者: 刘近春
  • 基金资助:
    山西省科技成果转化引导专项二批项目(201604D132042)

Correlation between serum hepatocyte growth factor and nonalcoholic fatty liver disease

Xiaojuan Zheng1, Fei Yang1, Jinchun Liu1,()   

  1. 1. Department of Gastroenterology, the First Clinical Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2017-07-05 Published:2018-01-15
  • Corresponding author: Jinchun Liu
  • About author:
    Corresponding author: Liu jinchun, Email:
引用本文:

郑晓娟, 杨斐, 刘近春. 血清肝细胞生长因子水平与非酒精性脂肪性肝病的相关性研究进展[J]. 中华临床医师杂志(电子版), 2018, 12(02): 115-118.

Xiaojuan Zheng, Fei Yang, Jinchun Liu. Correlation between serum hepatocyte growth factor and nonalcoholic fatty liver disease[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(02): 115-118.

非酒精性脂肪性肝病(NAFLD)发病率呈逐年上升趋势,其诊断及程度判断仍存在很多问题,肝组织病理诊断仍是诊断NAFLD的金标准,实验室检查难以做出可靠的诊断。研究发现,血清肝细胞生长因子(HGF)水平与NAFLD各疾病谱均存在一定关联,因此,研究HGF与NAFLD的关系及其如何影响后者的进展,对于更进一步了解NAFLD的发病机制及其预防和治疗工作有重要的意义。本文总结了近几年对HGF水平与NAFLD相关性的研究,以期为NAFLD病变程度的临床诊断提供一种新思路。

The incidence of NAFLD keeps increasing year by year, and there are still many problems in the diagnosis and evaluation of severity of NAFLD. Pathological examination of liver tissue is still the gold standard for the diagnosis of NAFLD, and it is difficult to make a reliable diagnosis based on laboratory examination. Studies have shown that serum hepatocyte growth factor (HGF) levels are associated with NAFLD spectrum. Therefore, clarifying the relationship between HGF and NAFLD and how HGF affects the progression of NAFLD is of great significance for the further understanding of the pathogenesis, prevention and treatment of this condition. This article reviews the recent advances in understanding the correlation between HGF level and NAFLD, with an aim to provide a new approach for the clinical diagnosis of NAFLD.

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