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中华临床医师杂志(电子版) ›› 2018, Vol. 12 ›› Issue (05) : 306 -309. doi: 10.3877/cma.j.issn.1674-0785.2018.05.010

所属专题: 文献

综述

benralizumab在重症嗜酸粒细胞型哮喘治疗中的价值
李文文1, 曹可2, 赵倩楠1, 康妍萌3, 张才擎3,()   
  1. 1. 271000 山东泰安,泰山医学院
    2. 250010 济南,山东大学
    3. 250014 济南,山东大学附属千佛山医院呼吸内科
  • 收稿日期:2018-01-31 出版日期:2018-03-01
  • 通信作者: 张才擎
  • 基金资助:
    山东省自然科学基金(ZR2016HL27)

Value of benralizumab in the treatment of severe eosinophilic asthma

Wenwen Li1, ke Cao2, Qiannan Zhao1, Yanmeng Kang3, Caiqing Zhang3,()   

  1. 1. Taishan Medical University, Taian 271000, China
    2. Shandong University, Jinan 250010, China
    3. Department of Respiratory Medicine, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, China
  • Received:2018-01-31 Published:2018-03-01
  • Corresponding author: Caiqing Zhang
  • About author:
    Corresponding author: Zhang Caiqing, Email:
引用本文:

李文文, 曹可, 赵倩楠, 康妍萌, 张才擎. benralizumab在重症嗜酸粒细胞型哮喘治疗中的价值[J]. 中华临床医师杂志(电子版), 2018, 12(05): 306-309.

Wenwen Li, ke Cao, Qiannan Zhao, Yanmeng Kang, Caiqing Zhang. Value of benralizumab in the treatment of severe eosinophilic asthma[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(05): 306-309.

支气管哮喘是一种常见的呼吸道慢性炎症性疾病,部分患者根据指南用药治疗后症状仍得不到控制,尤其在一些嗜酸粒细胞升高患者,吸入糖皮质激素及长效β2受体激动剂治疗后仍不能得到充分控制。benralizumab是一种人源化白细胞介素-5(IL-5)受体抗体,本文就benralizumab基本特性、临床应用现况、与其他IL-5抗体的比较以及应用前景等方面进行综述。

Bronchial asthma is a common chronic airway disease. The symptoms of some patients treated according to the guidelines are still not satisfactorily controlled, especially in eosinophilic asthma patients who are symptomatic despite treatment with inhaled corticosteroids and a long-acting beta2-agonist. Benralizumab is a humanized interleukin-5 receptor antibody. In this paper, we will review the fundamental characteristics of benralizumab as well as its clinical evaluation, safety, and application prospect in the treatment of eosinophilic asthma.

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