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中华临床医师杂志(电子版)

中华临床医师杂志(电子版) ›› 2019, Vol. 13 ›› Issue (06) : 454 -456. doi: 10.3877/cma.j.issn.1674-0785.2019.06.010

所属专题： 文献；

临床研究

炎性和非炎性疾病患者外周血25（OH）D水平与超敏C反应蛋白浓度的相关性
周丽英1, 蒋理2,†()   
  1. 1. 2100015　南京，上海长征医院南京分院肝脏科
    2. 210000　南京医科大学第一附属医院检验学部
  • 收稿日期:2018-09-05 出版日期:2019-03-15
  • 通信作者: 蒋理
  • 基金资助:
    江苏省实验诊断学重点实验室(ZDXKB2016005)

Association between peripheral blood levels of 25(OH)D and hypersensitive C-reactive protein in patients with inflammatory and non-inflammatory diseases

Liying Zhou1, Li Jiang2,†()   

  1. 1. Department of Hepatology, Nanjing Branch, Shanghai Changzheng Hospital, Nanjing 2120015, China
    2. Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China
  • Received:2018-09-05 Published:2019-03-15
  • Corresponding author: Li Jiang
  • About author:
    Corresponding author: Jiang Li, Email:
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引用本文：

周丽英, 蒋理. 炎性和非炎性疾病患者外周血25（OH）D水平与超敏C反应蛋白浓度的相关性[J]. 中华临床医师杂志(电子版), 2019, 13(06): 454-456.

Liying Zhou, Li Jiang. Association between peripheral blood levels of 25(OH)D and hypersensitive C-reactive protein in patients with inflammatory and non-inflammatory diseases[J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(06): 454-456.

目的

探讨炎性和非炎性疾病患者外周血25羟维生素D［25（OH）D］水平与超敏C反应蛋白（hs-CRP）浓度的相关性。

方法

回顾2017年9~11月已确诊的门诊或住院患者共281例，按是否存在炎性疾病分为炎性组130例和非炎性组151例，采用电化学发光法检测外周血25（OH）D水平，用散射比浊法检测外周血hs-CRP浓度，采用的Pearson相关分析分析25（OH）D水平与hs-CRP浓度的相关性。

结果

炎性疾病组25（OH）D水平与hs-CRP浓度呈负相关（r=-0.780，P<0.001）。非炎性疾病组25（OH）D水平与hs-CRP浓度呈负相关（r=-0.636，P<0.001）。

结论

炎性组与非炎性组患者外周血25（OH）D水平与hs-CRP浓度均呈负相关，炎性组的相关性高于非炎性组，其机制有待进一步探讨。

关键词: 超敏C反应蛋白, 25羟维生素D, 炎性疾病, 非炎性疾病
Objective

To investigate the correlation between peripheral blood levels of 25-hydroxyvitamin D [25(OH)D] and hypersensitive C-reactive protein (hs-CRP) in patients with inflammatory and non-inflammatory diseases.

Methods

A total of 281 patients (130 patients with inflammatory disease and 151 cases with non-inflammatory disease) were involved in this study between September 2017 and November 2017. The levels of 25(OH)D and hs-CRP in peripheral blood were detected by electrochemiluminescence and turbidimetry, respectively.

Results

The levels of 25(OH)D in the inflammatory disease group were significantly negatively correlated with those of hs-CRP (r=-0.780, P<0.001). In the non-inflammatory disease group, the 25(OH)D levels and hs-CRP concentrations had a weaker negative association (r=-0.636, P<0.001).

Conclusion

Peripheral blood levels of 25(OH)D are negatively associated with hs-CRP not only in patients with inflammatory disease but also in non-inflammatory populations. The correlation in the inflammatory group is significantly higher than that in the non-inflammatory group.

Key words: High-sensitivity, 25-hydroxy vitamin D, Inflammatory disease, Inflammatory
图1 炎性组25（OH）D水平和hs-CRP浓度相关性分析
图2 非炎性组25（OH）D水平和hs-CRP浓度相关性分析
1
Albert PJ, Proal AD, Marshalt TG. Vitamin D:the alternative hypothesis [J]. Autoimmun Rev, 2009, 8(8): 639-644.
2
Zakeri Z, Sandoughi M, Mashhadi MA, et al. Serum vitamin D level and disease activity in patients with recent onset rheumatoid arthritis [J]. Int J Rheum Dis, 2016, 19(4): 343-347.
3
Torki M, Gholamregaei A, Mirbagher L, et al. Vitamin D deficiency association with disease activity in patients with inflammatory bowel diseases [J]. Dig Dis Sci, 2015, 60(10): 3085-3091.
4
Devaraj S, Jialal G, Cook T, et al. Low Vitamin D levels in northern American adults with the metabolic syndrome [J]. Horm Metab Res, 2011, 43(1): 72-74.
5
Amer M, Qayyum R. Relation between Serum 25-hydroxyvitamin D and C-reactive protein in saymptomatic adults [J]. Am J Cardiol, 2012, 109(2): 226-230.
6
Melleuthin L, Wallaschofski H, Grotevendt A, et al. Association between Serum Vitamin D concentration and inflammatory markers in the general adult population [J]. Metab Clin Exp, 2014, 63(8): 1056-1062.
7
Kambis Sadeghi, Barhara Wessner, Ute laggner, et al. Vitamin D3 down-regulated monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns [J]. Eur J Immunol, 2006, 36(2): 361-370.
8
袁北芳，任立红. 维生素D及其受体的免疫调节作用研究进展 [J]. 国际免疫学杂志, 2014, 37(1): 52-56.
9
Hewison M. An update on Vitamin D and human immunity [J]. Clin Endocrinol, 2012, 76(3): 315-325.
10
Chen N, Wan Z, Han SF, et al. Effect of Vitamin D Supplementation on the circulating high-sensitivity C-reactive protein;a meta-analysis of randomiged controlled trails [J]. Nutrients, 2014, 6(6): 2206-2216.
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