切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2019, Vol. 13 ›› Issue (07) : 548 -551. doi: 10.3877/cma.j.issn.1674-0785.2019.07.014

所属专题: 文献

综述

肥胖对急性胰腺炎作用的研究进展
何家俊1, 周盟1, 李圆浩2, 杨楚婷2, 陈炜炜3, 刘军3,()   
  1. 1. 116000 大连医科大学第一临床医学院
    2. 225001 扬州大学2017级吴登云班
    3. 225001 扬州,江苏省苏北人民医院消化科
  • 收稿日期:2019-02-12 出版日期:2019-04-01
  • 通信作者: 刘军
  • 基金资助:
    中国博士后科学基金面上资助(2018M632260); 江苏省博士后科研资助计划(1701047C); 扬州市自然科学基金青年基金项目(YZ2017106)

Role of obesity in acute pancreatitis

Jiajun He1, Meng Zhou1, Yuanhao Li2, Chuting Yang2, Weiwei Chen3, Jun Liu3,()   

  1. 1. First Clinical Medical College, Dalian Medical University, Dalian 116000, China
    2. Grade 2017 of Wu Dengyun Class, Yangzhou University, Yangzhou 225001, China
    3. Department of Gastroenterology, Northern Jiangsu People's Hospital, Yangzhou 225001, China
  • Received:2019-02-12 Published:2019-04-01
  • Corresponding author: Jun Liu
  • About author:
    Corresponding author: Liu Jun, Email:
引用本文:

何家俊, 周盟, 李圆浩, 杨楚婷, 陈炜炜, 刘军. 肥胖对急性胰腺炎作用的研究进展[J]. 中华临床医师杂志(电子版), 2019, 13(07): 548-551.

Jiajun He, Meng Zhou, Yuanhao Li, Chuting Yang, Weiwei Chen, Jun Liu. Role of obesity in acute pancreatitis[J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(07): 548-551.

胰腺是人体的重要器官,具有内外分泌功能,在全身代谢、消化吸收中发挥重要作用。近年来,随着肥胖人群的增加,肥胖相关性急性胰腺炎的发病率逐年上升,且重症化趋势明显,然而肥胖在急性胰腺炎发生发展中的作用机制尚未阐明。本文旨在对肥胖在急性胰腺炎中的作用作一综述,以期为急性胰腺炎发病机制的理解和新治疗靶点的提出提供参考。

The pancreas is an essential organ that has endocrine and exocrine function and plays a vital role in metabolism, digestion, and absorption. In recent years, as the number of obese people increases, the morbidity of obesity-related acute pancreatitis (AP) is increasing. However, the exact pathogenesis of obesity-related AP has not been fully elucidated. The research of obesity-related AP has gradually attracted wide attention. In this paper, we review the recent progress in research on the role of obesity in AP to help understand the pathogenesis and new therapeutic targets of AP.

[33]
Betzel B, Homan J, Aarts E, et al. Acute pancreatitis as an adverse event in patients with the duodenal-jejunal bypass liner [J]. Endoscopy, 2015, 47(11): 1050-1053.
[34]
Alsohaibani FI, Alkasab M, Abufarhaneh EH, et al. Acute pancreatitis as a complication of intragastric balloons: a case series [J]. Obes Surg, 2019, 29(5): 1694-1696.
[35]
Sadr-Azodi O, Orsini N, Andren-Sandberg A, et al. Abdominal and total adiposity and the risk of acute pancreatitis: a population-based prospective cohort study [J]. Am J Gastroenterol, 2013, 108(1): 133-139.
[36]
Navina S, Acharya C, DeLany JP, et al. Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity [J]. Sci Transl Med, 2011, 3(107): 107-110.
[37]
Acharya C, Cline RA, Jaligama D, et al. Fibrosis reduces severity of acute-on-chronic pancreatitis in humans [J]. Gastroenterology, 2013, 145(2): 466-475.
[38]
Koutroumpakis E, Dasyam AK, Furlan A, et al. Isolated peripancreatic necrosis in acute pancreatitis is infrequent and leads to severe clinical course only when extensive: a prospective study from a us tertiary center [J]. J Clin Gastroenterol, 2016, 50(7): 589-595.
[39]
Mossner J, Bodeker H, Kimura W, et al. Isolated rat pancreatic acini as a model to study the potential role of lipase in the pathogenesis of acinar cell destruction [J]. Int J Pancreatol, 1992, 12(3): 285-296.
[40]
Noel P, Patel K, Durgampudi C, et al. Peripancreatic fat necrosis worsens acute pancreatitis independent of pancreatic necrosis via unsaturated fatty acids increased in human pancreatic necrosis collections [J]. Gut, 2016, 65(1): 100-111.
[41]
Durgampudi C, Noel P, Patel K, et al. Acute lipotoxicity regulates severity of biliary acute pancreatitis without affecting its initiation [J]. Am J Pathol, 2014, 184(6): 1773-1784.
[1]
Peery AF, Crockett SD, Murphy CC, et al. Burden and cost of gastrointestinal, liver, and pancreatic diseases in the united states: update 2018 [J]. Gastroenterology, 2019, 156(1): 254.e11-272.e11.
[2]
Wu D, Tang M, Zhao Y, et al. Impact of seasons and festivals on the onset of acute pancreatitis in Shanghai, China [J]. Pancreas, 2017, 46(4): 496-503.
[3]
Forsmark Ch E, Vege SS, Wilcox CM. Acute Pancreatitis [J]. N Engl J Med, 2017, 376(6): 598-599.
[4]
Banks PA, Bollen TL, Dervenis C, et al. Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus [J]. Gut, 2013, 62(1): 102-111.
[5]
Ogden CL, Carroll MD, Curtin LR, et al. Prevalence of overweight and obesity in the United States, 1999-2004 [J]. Jama, 2006, 295(13): 1549-1555.
[6]
Ogden CL, Carroll MD, Kit BK, et al. Prevalence of childhood and adult obesity in the United States, 2011-2012 [J]. Jama, 2014, 311(8): 806-814.
[7]
Finkelstein EA, Trogdon JG, Cohen JW, et al. Annual medical spending attributable to obesity: payer-and service-specific estimates [J]. Health Aff (Millwood), 2009, 28(5): w822-w831.
[8]
Wang Y, Beydoun MA, Liang L, et al. Will all Americans become overweight or obese? estimating the progression and cost of the US obesity epidemic [J]. Obesity (Silver Spring), 2008, 16(10): 2323-2330.
[9]
Curry SJ, Krist AH, Owens DK, et al. Behavioral weight loss interventions to prevent obesity-related morbidity and mortality in adults: US Preventive Services Task Force Recommendation Statement [J]. Jama, 2018, 320(11): 1163-1171.
[10]
Krishna SG, Hinton A, Oza V, et al. Morbid obesity is associated with adverse clinical outcomes in acute pancreatitis: a propensity-matched study [J]. Am J Gastroenterol, 2015, 110(11): 1608-1619.
[11]
Khatua B, El-Kurdi B, Singh VP. Obesity and pancreatitis [J]. Curr Opin Gastroenterol, 2017, 33(5): 374-382.
[12]
Radmard AR, Merat S, Kooraki S, et al. Gallstone disease and obesity: a population-based study on abdominal fat distribution and gender differences [J]. Ann Hepatol, 2015, 14(5): 702-709.
[13]
Flint R. Differences in acute general surgical admissions between obese or overweight patients compared to normal-sized patients [J]. N Z Med J, 2015, 128(1424): 35-41.
[14]
Lerch MM, Gorelick FS. Models of acute and chronic pancreatitis [J]. Gastroenterology, 2013, 144(6): 1180-1193.
[15]
Lee JY, Keane MG, Pereira S. Diagnosis and treatment of gallstone disease [J]. Practitioner, 2015, 259(1783): 15-19, 2.
[16]
Coban G, Yildirim E, Gokturk S, et al. Body mass index, cholecystitis, cholelithiasis, pancreatitis and imaging of common bile duct stones [J]. Am J Med Sci, 2014, 347(5): 364-369.
[17]
Pitha J, Kovar J, Blahova T. Fasting and nonfasting triglycerides in cardiovascular and other diseases [J]. Physiol Res, 2015, 64 (Suppl 3): S323-S330.
[18]
Vipperla K, Somerville C, Furlan A, et al. Clinical profile and natural course in a large cohort of patients with hypertriglyceridemia and pancreatitis [J]. J Clin Gastroenterol, 2017, 51(1): 77-85.
[19]
Shah AS, Wilson DP. Primary hypertriglyceridemia in children and adolescents [J]. J Clin Lipidol, 2015, 9(5 Suppl): S20-S28.
[20]
Blackett PR, Wilson DP, McNeal CJ. Secondary hypertriglyceridemia in children and adolescents [J]. J Clin Lipidol, 2015, 9(5 Suppl): S29-S40.
[21]
Albai O, Roman D, Frandes M. Hypertriglyceridemia, an important and independent risk factor for acute pancreatitis in patients with type 2 diabetes mellitus [J]. Ther Clin Risk Manag, 2017, 13: 515-522.
[22]
Monami M, Nreu B, Scatena A, et al. Safety issues with glucagon-like peptide-1 receptor agonists (pancreatitis, pancreatic cancer and cholelithiasis): Data from randomized controlled trials [J]. Diabetes Obes Metab, 2017, 19(9): 1233-1241.
[23]
Mondragon A, Davidsson D, Kyriakoudi S, et al. Divergent effects of liraglutide, exendin-4, and sitagliptin on beta-cell mass and indicators of pancreatitis in a mouse model of hyperglycaemia [J]. PLoS One, 2014, 9(8): e104873.
[24]
Kobayashi T, Manivel JC, Bellin MD, et al. Correlation of pancreatic histopathologic findings and islet yield in children with chronic pancreatitis undergoing total pancreatectomy and islet autotransplantation [J]. Pancreas, 2010, 39(1): 57-63.
[25]
Singh S, Chang HY, Richards TM, et al. Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study [J]. JAMA Intern Med, 2013, 173(7): 534-539.
[26]
Rehman MB, Tudrej BV, Soustre J, et al. Efficacy and safety of DPP-4 inhibitors in patients with type 2 diabetes: Meta-analysis of placebo-controlled randomized clinical trials [J]. Diabetes Metab, 2017, 43(1): 48-58.
[27]
Liao KF, Lin CL, Lai SW, et al. Sitagliptin use and risk of acute pancreatitis in type 2 diabetes mellitus: A population-based case-control study in Taiwan [J]. Eur J Intern Med, 2016, 27: 76-79.
[28]
Storgaard H, Cold F, Gluud LL, et al. Glucagon-like peptide-1 receptor agonists and risk of acute pancreatitis in patients with type 2 diabetes [J]. Diabetes Obes Metab, 2017, 19(6): 906-908.
[29]
Chang J, Corcelles R, Boules M, et al. Predictive factors of biliary complications after bariatric surgery [J]. Surg Obes Relat Dis, 2016, 12(9): 1706-1710.
[30]
Kumaravel A, Zelisko A, Schauer P, et al. Acute pancreatitis in patients after bariatric surgery: incidence, outcomes, and risk factors [J]. Obes Surg, 2014, 24(12): 2025-2030.
[42]
Patel K, Trivedi RN, Durgampudi C, et al. Lipolysis of visceral adipocyte triglyceride by pancreatic lipases converts mild acute pancreatitis to severe pancreatitis independent of necrosis and inflammation [J]. Am J Pathol, 2015, 185(3): 808-819.
[43]
Choh AC, Demerath EW, Lee M, et al. Genetic analysis of self-reported physical activity and adiposity: the Southwest Ohio Family Study [J]. Public Health Nutr, 2009, 12(8): 1052-1060.
[31]
Arapis K, Tammaro P, Goujon G, et al. Elevated plasma pancreatic enzyme concentrations after Roux-en-Y gastric bypass may indicate closed loop obstruction [J]. Ann R Coll Surg Engl, 2017, 99(2): e62-e64.
[32]
Unal B, Uzun OC, Bassorgun CI, et al. A rare complication of gastric bypass (weight loss) surgery: nesidioblastosis [J]. Int J Surg Pathol, 2015, 23(1): 68-70.
[1] 孙环蕊, 张若鹏. 复发性流产与肠道微生物群失衡[J]. 中华妇幼临床医学杂志(电子版), 2022, 18(05): 506-511.
[2] 聂锋, 李婉珍. 不打针不吃药不输液徒手治疗糖尿病一例报道[J]. 中华普外科手术学杂志(电子版), 2023, 17(03): 354-354.
[3] 夫尔多斯·阿马努拉, 黄海军, 马尚智, 秦鹏, 王金龙. 腹腔镜下袖式胃切除术不同切除线治疗病态肥胖症的近远期临床疗效观察[J]. 中华普外科手术学杂志(电子版), 2023, 17(01): 32-35.
[4] 马永斌, 玉苏普江·伊明江, 皮尔低瓦斯, 买买提·依斯热依力, 依力汗·依明, 克力木, 艾克拜尔·艾力. 肥胖合并2型糖尿病患者腹腔镜袖状胃切除术后早期糖脂代谢变化[J]. 中华普外科手术学杂志(电子版), 2023, 17(01): 23-26.
[5] 苏慧媛, 宋洪涛, 高巍, 武忠. 针刺治疗单纯性肥胖的系统评价和Meta分析[J]. 中华针灸电子杂志, 2023, 12(03): 123-128.
[6] 董正妮, 张珑耀. 穴位埋线疗法治疗单纯性肥胖的研究进展[J]. 中华针灸电子杂志, 2023, 12(02): 57-61.
[7] 陈笑梅, 陈文辉, 赵宛鄂, 郭婕, 苏超, 付志菊, 杨华, 董志勇, 王存川. 可吞咽自吸收新型胃内球囊治疗轻度肥胖症:一例病例报告[J]. 中华肥胖与代谢病电子杂志, 2023, 09(03): 215-217.
[8] 刘澳, 周菁, 孙永兵, 和俊雅, 林新贝, 乔琦, 李中林, 张建成, 武肖玲, 邹智, 胡扬喜, 肖新广, 吕雪, 李昊, 李永丽. 减重代谢手术后神经影像改变与认知功能评估的研究进展[J]. 中华肥胖与代谢病电子杂志, 2023, 09(03): 203-208.
[9] 中国医师协会外科医师分会肥胖和糖尿病外科医师委员会, 中国肥胖代谢外科研究协作组. 肥胖代谢外科个案管理术前临床路径中国专家共识(2023版)[J]. 中华肥胖与代谢病电子杂志, 2023, 09(02): 73-82.
[10] 闫海, 邵怡凯, 姚琪远. 减重代谢外科在心血管疾病防治中的临床意义与前景[J]. 中华肥胖与代谢病电子杂志, 2023, 09(02): 137-142.
[11] 伍振鹏, 乔钰涵, 向林, 江云颂, 彭居正, 吴丽娜, 程吕佳, 关炳生, 庄子康, 杨景哥. 腹腔镜袖状胃切除术中胃窦切缘与幽门的距离对术后胃食管反流病及减重效果的影响[J]. 中华肥胖与代谢病电子杂志, 2023, 09(01): 4-11.
[12] 孙永兵, 周菁, 温东朋, 和俊雅, 林新贝, 乔琦, 李中林, 张诚, 王志凯, 张建成, 武肖玲, 邹智, 王勇, 李永丽. 减重代谢手术后机体改变的脑–肠–菌轴机制研究进展[J]. 中华肥胖与代谢病电子杂志, 2023, 09(01): 43-49.
[13] 赵稳, 刘浩, 武现生, 金露佳, 陈鹏, 李丁昌, 高文星, 刘先强, 董光龙. 胃束带侵蚀致复杂食道及胃瘘的处理——一例病例报告及文献回顾[J]. 中华肥胖与代谢病电子杂志, 2023, 09(01): 62-67.
[14] 陈义钢, 孙年丰, 范新奇, 夏加增. 超微创手术器械在腹腔镜袖状胃手术中的应用[J]. 中华肥胖与代谢病电子杂志, 2022, 08(04): 243-248.
[15] 王国凤, 惠媛, 王凤力, 闫永鑫. 减重手术对肥胖合并甲状腺功能减退症患者甲状腺功能和左甲状腺素替代治疗剂量影响的Meta分析[J]. 中华肥胖与代谢病电子杂志, 2022, 08(04): 263-270.
阅读次数
全文


摘要