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中华临床医师杂志(电子版) ›› 2019, Vol. 13 ›› Issue (09) : 684 -688. doi: 10.3877/cma.j.issn.1674-0785.2019.09.009

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综述

神经调节蛋白4在肥胖及代谢性疾病作用的研究进展
程贤鹦1,(), 何银辉2   
  1. 1. 310033 杭州,浙江医院妇产科
    2. 323000 丽水市中心医院,温州医科大学附属第五医院,浙江大学丽水医院内分泌科
  • 收稿日期:2019-03-16 出版日期:2019-05-01
  • 通信作者: 程贤鹦
  • 基金资助:
    浙江省中医药科技计划项目(2018ZB008)

Role of neuregulin 4 in obesity and metabolic disease

Xianying Cheng1,(), Yinhui He2   

  1. 1. Department of Gynecology and Obstetrics, Zhejiang Hospital, Hangzhou 310033, China
    2. Department of Endocrinology, Lishui Central Hospital, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui 323000, China
  • Received:2019-03-16 Published:2019-05-01
  • Corresponding author: Xianying Cheng
  • About author:
    Corresponding author: Cheng Xianying, Email:
引用本文:

程贤鹦, 何银辉. 神经调节蛋白4在肥胖及代谢性疾病作用的研究进展[J/OL]. 中华临床医师杂志(电子版), 2019, 13(09): 684-688.

Xianying Cheng, Yinhui He. Role of neuregulin 4 in obesity and metabolic disease[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(09): 684-688.

脂肪内分泌因子在维持全身能量平衡和糖脂代谢方面具有重要作用。越来越多的证据表明神经调节蛋白4(NRG4)与肥胖及代谢性疾病的发生发展有密切关系,未来通过深入的研究,NRG4有望成为具有治疗肥胖相关多种疾病生物制剂的潜力。

Adipoendocrine factor plays an important role in maintaining systemic energy balance and glycolipid metabolism. Increasing evidence has shown that neuregulin 4 (NRG4) plays an important role in the development of obesity and metabolic disease. Future studies may result in the development of NRG4 as an effective therapeutic biologic for the treatment of obesity-associated disorders.

图1 NRG4作用机制[13]
1
Wang GX, Zhao XY, Meng ZX, et al. The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis [J]. Nat Med, 2014, 20(12): 1436-1443.
2
Chen LL, Peng MM, Zhang JY, et al. Elevated circulating neuregulin4 level in patients with diabetes [J]. Diabetes Metab Res Rev, 2017, 33(4): e2870.
3
Kang YE, Kim JM, Choung S, et al. Comparison of serum Neuregulin 4 (Nrg4) levels in adults with newly diagnosed type 2 diabetes mellitus and controls without diabetes [J]. Diabetes Res Clin Pract, 2016, 117: 1-3.
4
Dai YN, Zhu JZ, Fang ZY, et al. A case-control study: Association between serum neuregulin 4 level and non-alcoholic fatty liver disease [J]. Metabolism, 2015, 64(12): 1667-1673.
5
Cai CF, Lin Mz, Xu YF, et al. Association of circulating neuregulin 4 with metabolic syndrome in obese adults: a cross-sectional study [J]. BMC Med, 2016, 14(1): 165.
6
Temur M, Calan M, Akşit M, et al. Increased serum neuregulin 4 levels in women with polycystic ovary syndrome: a case-control study [J]. Ginekol Pol, 2017, 88(10): 517-522.
7
Jiang J, Lin M, Xu Y, et al. Circulating neuregulin 4 levels are inversely associated with subclinical cardiovascular disease in obese adults [J]. Sci Rep, 2016, 6: 36710.
8
Bublil EM, Yarden Y. The EGF receptor family: spearheading a merger of signaling and therapeutics [J]. Curr Opin Cell Biol, 2007, 19: 124-134.
9
Gumà A, Martínez-Redondo V, López-Soldado I, et al. Emerging role of neuregulin as a modulator of muscle metabolism [J]. Am J Physiol Endocrinol Metab, 2010, 298(4): E742-E750.
10
Harari D, Tzahar E, Romano J, et al. Neuregulin-4:a novel growth factor that acts through the ErbB-4 receptor tyro sinekinase [J]. Oncogene, 1999, 18(17): 2681-2689.
11
Rosell M, Kaforou M, Frontini A, et al. Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice [J]. Am J Physiol Endocrinol Metab, 2014, 306(8): E945-E964.
12
Wu J, Bostrom P, Sparks LM, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human [J]. Cell, 2012, 150(2): 366-376.
13
Pfeifer A. NRG4: An endocrine link between brown adipose tissue and liver [J]. Cell Metab, 2015, 21(1): 13-14.
14
McElroy SJ, Castle SL, Bernard JK, et al. The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis [J]. Am J Pathol, 2014, 184(10): 2768-2778.
15
Chen ZM, Wang GX, Ma SL, et al. Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders [J]. Mol Metab, 2017, 6(8): 863-872.
16
Ma YJ, Gao MM, Liu D. Preventing high fat diet-induced obesity and improving insulin sensitivity through neuregulin 4 gene Transfer [J]. Sci Rep, 2016, 6: 26242.
17
South JC, Blackburn E, Brown IR, et al. The neuregulin system of ligands and their receptors in rat islets of langerhans [J]. Endocrinology, 2013, 154(7): 2385-2392.
18
Zhang L, Fu YM, Zhou N, et al. Circulating neuregulin 4 concentrations in patients with newly diagnosed type 2 diabetes: a cross-sectional study [J]. Endocrine, 2017, 57(3): 535-538.
19
Yan PJ, Xu Y, Wan Q, et al. Plasma Neuregulin 4 levels are associated with metabolic syndrome in patients newly diagnosed with type 2 diabetes mellitus [J]. Dis Markers, 2018, 2018(3): 1-11.
20
Kurek EM, Yayla AC, Sahin EG, et al. Clinical significance of neuregulin 4 (NRG4) in gestational diabetes mellitus [J]. Gynecol Endocrinol, 2018, 34(7): 605-608.
21
Jensen MD, Ryan DH, Apovian CM, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society [J]. J Am Coll Cardiol, 2014, 63(25 Pt B): 2985-3023.
22
Bernard JK, McCann SP, Bhardwaj V, et al. Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo [J]. J Biol Chem, 2012, 287(47): 39850-39858.
23
Feng YJ, Teitelbaum DH. Epidermal growth factor/TNF-α transactivation modulates epithelial cell proliferation and apoptosis in a mouse model of parenteral nutrition [J]. Am J Physiol Gastrointest Liver Physiol, 2012, 302(2): G236-G249.
24
Schumacher MA, Hedl M, Abraham C, et al. ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation [J]. Cell Death Dis, 2017, 8(2): e2622.
25
Yan PJ, Xu Y, Wan Q, et al. Decreased plasma neuregulin 4 concentration is associated with increased high-sensitivity C-reactive protein in newly diagnosed type 2 diabetes mellitus patients: a cross-sectional study [J]. Acta Diabetol, 2017, 54(12): 1091-1099.
26
de Mutsert R, Sun Q, Willett WC, et al. Overweight in early adulthood, adult weight change, and risk of type 2 diabetes, cardiovascular diseases, and certain cancers in men: a cohort study [J]. Am J Epidemiol, 2014, 179: 353-1365.
27
Liu L, Miura K, Fujiyoshi A, et al. Impact of metabolic syndrome on the risk of cardiovascular disease mortality in the United States and in Japan [J]. Am J Cardiol, 2014, 113(1): 84-89.
28
Tao LX, Li X, Zhu HP, et al. Association of hematological parameters with metabolic syndrome in Beijing adult population: a longitudinal study [J]. Endocrine, 2014, 46(3): 485-495.
29
Aguilar M, Bhuket T, Torres S, et al. Prevalence of the metabolic syndrome in the United States, 2003-2012 [J]. JAMA, 2015, 313(19): 1973-1974.
30
Andrus B, Lacaille D. 2013 ACC/AHA guideline on the assessment of cardiovascular risk [J]. J Am Coll Cardiol, 2014, 63(25): 2886.
31
Jensen MD, Ryan DH, Apovian CM, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society [J]. J Am Coll Cardiol, 2014, 63(25): 2985-3023.
32
Mendez-Sanchez N, Arrese M, Zamora-Valdes D, et al. Current concepts in the pathogenesis of nonalcoholic fatty liver disease [J]. Liver Int, 2007, 27(4): 423-433.
33
Stefan N, Schick F, Häring HU, et al. Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease [J]. N Engl J Med, 2014, 371(23): 2237-2238.
34
den Engelsen C, Koekkoek PS, Gorter KJ, et al. High-sensitivity C-reactive protein to detect metabolic syndrome in a centrally obese population: a cross-sectional analysis [J]. Cardiovascular Diabetology, 2012, 11(1): 25.
35
Liu SQ, Tefft BJ, Roberts DT, et al. Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia [J]. Am J Physiol Heart Circ Physiol, 2012, 303(12): H1446-H1458.
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