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中华临床医师杂志(电子版) ›› 2019, Vol. 13 ›› Issue (09) : 693 -697. doi: 10.3877/cma.j.issn.1674-0785.2019.09.011

所属专题: 文献

综述

抗癫痫药物对内分泌功能影响的研究进展
赵惠敏1, 石凯丽2,()   
  1. 1. 030000 太原,山西医科大学
    2. 030013 太原,山西省儿童医院神经内科
  • 收稿日期:2019-03-14 出版日期:2019-05-01
  • 通信作者: 石凯丽
  • 基金资助:
    山西省卫生计生委科研课题(2017086)

Advances in research of effect of antiepileptic drugs on endocrine function

Huimin Zhao1, Kaili Shi2,()   

  1. 1. Shanxi Medical University, Taiyuan 030000, China
    2. Department of Neurology, Shanxi Children's Hospital, Taiyuan 030013, China
  • Received:2019-03-14 Published:2019-05-01
  • Corresponding author: Kaili Shi
  • About author:
    Corresponding author: Shi Kaili, Email:
引用本文:

赵惠敏, 石凯丽. 抗癫痫药物对内分泌功能影响的研究进展[J]. 中华临床医师杂志(电子版), 2019, 13(09): 693-697.

Huimin Zhao, Kaili Shi. Advances in research of effect of antiepileptic drugs on endocrine function[J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(09): 693-697.

抗癫痫药物为目前癫痫的主要治疗手段,除有效控制癫痫发作,抗癫痫药物的相关不良反应也日益受到关注。国内外大量研究表明,抗癫痫药物会影响患者的内分泌功能,从而导致月经紊乱、性问题、生育困难及甲状腺功能损害。本文将从传统及新型抗癫痫药物对性激素水平及甲状腺素水平的影响进行综述。

Antiepileptic drugs are the main treatment for epilepsy. In addition to effective control of seizures, the side effects of antiepileptic drugs are also increasingly reported. A large number of studies have shown that antiepileptic drugs can affect the endocrine function of patients, resulting in menstrual disorders, sexual problems, reproductive difficulties, and thyroid dysfunction. This article will review the effects of traditional and new antiepileptic drugs on sex hormone and thyroxine levels.

1
全凤英,杨小翠. 癫痫患者生活质量的研究进展 [J]. 医学综述, 2015, 21(6): 1023-1024.
2
Svalheim S, Sveberg L, Mochol M, et al. Interactions between antiepileptic drugs and hormones [J]. Seizure, 2015, 28: 12-17.
3
马昱,汪昕. 性激素与癫痫 [J]. 中华神经医学杂志, 2004, 3(2): 154-157.
4
Kumar S, Kaur G. Second generation anti-epileptic drugs adversely affect reproductive functions in young non-epileptic female rats [J]. Eur Neuropsychopharmacol, 2014, 24(10): 1709-1718.
5
Hayashi T, Yoshinaga A, Ohno R, et al. Asthenozoospermia: possible association with long-term exposure to an anti-epileptic drug of carbarnazepine [J]. Int J Urol, 2005, 12(1): 113-114.
6
范真,孙红斌,黄斌. 抗癫痫药物对男性癫痫患者生殖的影响 [J]. 中华神经科杂志, 2015, 48(3): 221-223.
7
Bhattacharjee N, Pathak S, Khuda-Bukhsh AR, et al. Amelioration of carcinogen-induced toxicity in mice by administration of a potentized homeopathic drug, Natrum Sulphuricum 200 [J]. Evid Based Complement Alternat Med, 2009, 6(1): 65-75.
8
Mikkonen K, Tapanainen P, Pakarinen AJ, et al. Serum androgen levels and testicular structure during pubertal maturation in male subjects with epilepsy [J]. Epilepsia, 2004, 45(7): 769-776.
9
Krogenaes AK, Taubøll E, Stien A, et al. Valproate affects reproductive endocrine function, testis diameter and some semen variables in non-epileptic adolescent goat bucks [J]. Theriogenology, 2008, 70(1): 15-26.
10
陈浪. 丙戊酸钠、奥卡西平对新诊断青年男性癫痫患者精液、性功能、性激素影响的对照研究 [D]. 四川: 西南医科大学, 2018: 1-70.
11
Isojärvi JI, Laatikainen TJ, Pakarinen AJ, et al. Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy [J]. N Engl J Med, 1993, 329(19): 1383-1388.
12
Taubøll E, Gregoraszczuk EL, Wojtowicz AK, et al. Effects of levetiracetam and valproate on reproductive endocrine function studied in human ovarian follicular cells [J]. Epilepsia, 2009, 50(8): 1868-1874.
13
Hattori N, Fujiwara H, Maeda M, et al. Epoxide hydrolase affects estrogen production in the human ovary [J]. Endocrinology, 2000, 141(9): 3353-3365.
14
El-Khayat HA, Abd El-Basset FZ, Tomoum HY, et al. Physical growth and endocrinal disorders during pubertal maturation in girls with epilepsy [J]. Epilepsia, 2004, 45(9): 1106-1115.
15
刘军,邢福,祺石宇, 等. 丙戊酸钠对少女癫痫患者性激素的影响 [J]. 中华神经医学杂志, 2012, 11(10): 989-991.
16
Löfgren E, Tapanainen JS, Koivunen R, et al. Effects of carbamazepine and oxcarbazepine on the reproductive endocrine function in women with epilepsy [J]. Epilepsia, 2006, 47(9): 1441-1446.
17
Wu DM, Chen L, Ji FY, et al. The effects of oxcarbazepine, levetiracetam, and lamotrigine on semen quality, sexual function, and sex hormones in male adults with epilepsy [J]. Epilepsia, 2018, 59(7): 1344-1350.
18
Harden CL, Nikolov BG, Kandula P, et al. Effect of levetiracetam on testosterone levels in male patients [J]. Epilepsia, 2010, 51(11): 2348-2351.
19
Svalheim S, Taubøll E, Luef G, et al. Differential effects of levetiracetam, carbamazepine, and lamotrigine on reproductive endocrine function in adults [J]. Epilepsy Behav, 2009, 16(2): 281-287.
20
Xu XT, Zhang HZ, Xu Y, et al. Effects of antiepileptic drugs on reproductive endocrine function, sexual function and sperm parameters in Chinese Han men with epilepsy [J]. Clin Neurosci, 2013, 20(11): 1492-1497.
21
Ceylan M, Yalcin A, Bayraktutan OF, et al. Effects of levetiracetam monotherapy on sperm parameters and sex hormones: Data from newly diagnosed patients with epilepsy [J]. Seizure, 2016, 41: 70-74.
22
Taubøll E, Gregoraszczuk EL, Tworzydø A, et al. Comparison of reproductive effects of levetiracetam and valproate studied in prepubertal porcine ovarian follicular cells [J]. Epilepsia, 2006, 47(9): 1580-1583.
23
Svalheim S, Tauboll E, Surdova K, et al. Long-term levetiracetam treatment affects reproductive endocrine function in female Wistar rats [J]. Seizure, 2008, 17(2): 203-209.
24
姚春美,高玉兴,李淑兰, 等. 抗癫痫药物对生殖内分泌功能影响的实验研究 [J]. 山东大学学报(医学版), 2009, 47(10): 35-38.
25
王葳,于淑杰,沈乃霞, 等. 左乙拉西坦对癫痫儿童血清性激素水平影响的研究 [J]. 中国现代药学应用, 2010, 4(10): 161-162.
26
Lee CY, Fu WM, Chen CC, et al. Lamotrigine inhibits postsynaptic AMPA receptor and glutamate release in the dentate gyrus [J]. Epilepsia, 2008, 49(5): 888-897.
27
Wu DM, Chen L, Ji FY, et al. The effects of oxcarbazepine, levetiracetam, and lamotrigine on semen quality, sexual function, and sex hormones in male adults with epilepsy [J]. Epilepsia, 2018, 59(7): 1344-1350.
28
Tanaka K, Kodama S, Yokoyama S, et al. Thyroid function in children with long-term anticonvulsant treatment [J]. Pediatr Neurosci, 1987, 13(2): 90-94.
29
Verrotti A, Laus M, Scardapane A, et al. Thyroid hormones in children with epilepsy during longterm administration of carbamazepine and valproate [J]. Eur J Endocrinol, 2008, 160(1): 81-86.
30
Yılmaz Ü, Yılmaz TS, Akıncı G, et al. The effect of antiepileptic drugs on thyroid function in children [J]. Seizure, 2014, 23(1): 29-35.
31
Sahu JK, Gulati S, Kabra M, et al. Evaluation of subclinical hypothyroidism in ambulatory children with controlled epilepsy on valproate monotherapy [J]. J Child Neurol, 2011, 27(5): 594-597.
32
Cansu A, Serdaroğlu A, Çamurdan O, et al. The evaluation of thyroid functions, thyroid antibodies, and thyroid volumes in children with epilepsy during short-term administration of oxcarbazepine and valproate [J]. Epilepsia, 2006, 47(11): 1855-1859.
33
Fu YS, Yao CC, Ming JC, et al. Effects of antiepileptic drugs on thyroid hormone function in epilepsy patients [J]. Seizure, 2017, 48: 7-10.
34
Adhimoolam M, Arulmozhi R. Effect of antiepileptic drug therapy on thyroid hormones among adult epileptic patients: an analytical cross-sectional study [J]. J Res Pharm Pract, 2016, 5(3): 171-174.
35
Garoufi A, Koemtzidou E, Katsarou E, et al. Lipid profile and thyroid hormone concentrations in children with epilepsy treated with oxcarbazepine monotherapy: a prospective long-term study [J]. Eur J Neurol, 2014, 21(1): 118-123.
36
Hamed SA. The effect of antiepileptic drugs on thyroid hormonal function: causes and implications [J]. Expert Rev Clin Pharmacol, 2015, 8(6): 41-50.
37
Benedetti MS, Whomsley R, Baltes E, et al. Alteration of thyroid hormone homeostasis by antiepileptic drugs in humans: involvement of glucuronosyltransferase induction [J]. Eur J Clin Pharmacol, 2005, 61(12): 863-872.
38
Aygün F, Ekici B, Aydınlı N, et al. Thyroid hormones in children on antiepileptic therapy [J]. Int J Neurosci, 2012, 122(2): 69-73.
39
李斌,王胜泉,周辉. 左乙拉西坦对癫痫患儿甲状腺激素及甲状旁腺激素的影响 [J]. 中国临床医学, 2018, 25(4): 662-664.
40
梁益,喻良. 拉莫三嗪对癫痫患者血清甲状腺激素水平的影响 [J]. 临床神经病学杂志, 2011, 24(1): 65-67.
41
Adhimoolam M, Arulmozhi R. Effect of antiepileptic drug therapy on thyroid hormones among adult epileptic patients: An analytical cross-sectional study [J]. Res Pharm Pract, 2016, 5(3): 171-174.
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