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中华临床医师杂志(电子版) ›› 2019, Vol. 13 ›› Issue (09) : 698 -701. doi: 10.3877/cma.j.issn.1674-0785.2019.09.012

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综述

亚甲蓝光动力治疗感染相关性皮肤病的研究进展
李婵婵1, 吴剑波1,()   
  1. 1. 430071 武汉大学中南医院皮肤科
  • 收稿日期:2019-04-05 出版日期:2019-05-01
  • 通信作者: 吴剑波

Progress in methylene blue mediated photodynamic therapy for infection-related skin diseases

Chanchan Li1, Jianbo Wu1,()   

  1. 1. Department of Dermatology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
  • Received:2019-04-05 Published:2019-05-01
  • Corresponding author: Jianbo Wu
  • About author:
    Corresponding author: Wu Jianbo, Email:
引用本文:

李婵婵, 吴剑波. 亚甲蓝光动力治疗感染相关性皮肤病的研究进展[J/OL]. 中华临床医师杂志(电子版), 2019, 13(09): 698-701.

Chanchan Li, Jianbo Wu. Progress in methylene blue mediated photodynamic therapy for infection-related skin diseases[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(09): 698-701.

亚甲蓝属吩噻嗪类衍生物,是光动力疗法中常用的光敏剂。体外研究已证实亚甲蓝光动力治疗(MB-PDT)可显著抑制或杀灭众多的致病细菌、真菌、病毒及原生生物。近年来,关于MB-PDT治疗感染性皮肤病的临床研究逐渐增多。现有的研究表明,MB-PDT对于多种感染相关性皮肤病具有肯定的治疗效果,且不良反应少、价格低廉,具有良好的应用前景。

Methylene blue belongs to a phenothiazine derivative that is a commonly used photosensitizer in photodynamic therapy (PDT). In vitro studies have confirmed that methylene blue mediated photodynamic therapy (MB-PDT) has significant inhibitory or killing effects on numerous pathogens like bacteria, fungi, viruses, and protists. In recent years, clinical studies on MB-PDT treatment for infection-associated skin diseases have gradually increased, and shown therapeutic effect on a variety of infection-associated skin diseases. Compared with other photosemsitizers, MB-PDT has less adverse reactions, lower prices, and good application prospects.

1
周训蓉,李江萍.亚甲蓝的化学、药理研究及临床应用进展 [J]. 中国药业, 2008, 17(4): 62-64.
2
Choi SS, Lee HK, Chae HS. Synergistic in vitro photodynamic antimicrobial activity of methylene blue and chitosan against Helicobacter pylori 26695 [J]. Photodiagnosis Photodyn Ther, 2014, 11(4): 526-532.
3
Mfouo-Tynga I, Abrahamse H. Cell death pathways in photodynamic therapy of cancer [J]. Int J Mol Sci, 2015, 16(5): 10228-10241.
4
Schneider JE, Price S, Maidt L, et al. Methylene blue plus light mediates 8-hydroxy 2′-deoxyguanosine formation in DNA preferentially over strand breakage [J]. Nucleic Acids Res, 1990, 18(3): 631-635.
5
Carvalho GG, Felipe MP, Costa MS. Felipe and M.S. Costa, The photodynamic effect of methylene blue and toluidine blue on Candida albicans is dependent on medium conditions [J]. J Microbiol, 2009. 47(5): 619-623.
6
Kashef N, Ravaei Sharif Abadi G, Djavid GE. Phototoxicity of phenothiazinium dyes against methicillin-resistant Staphylococcus aureus and multi-drug resistant Escherichia coli [J]. Photodiagnosis Photodyn Ther, 2012, 9(1): 11-15.
7
Gomes TF, Pedrosa MM, de Toledo ACL, et al. Bactericide effect of methylene blue associated with low-level laser therapy in Escherichia coli bacteria isolated from pressure ulcers [J]. Lasers Med Sci, 2018. 33(8): 1723-1731.
8
Azizi A, Shohrati P, Goudarzi M, et al. Comparison of the effect of photodynamic therapy with curcumin and methylene blue on streptococcus mutans bacterial colonies [J]. Photodiagnosis Photodyn Ther, 2019, 27: 203-209.
9
Tian RB, Asmar S, Napez C, et al. Effectiveness of purified methylene blue in an experimental model of Mycobacterium ulcerans infection [J]. Int J Antimicrob Agents, 2017, 49(3): 290-295.
10
Krasnoselskiy NV, Simonova LI, Gertman VZ, et al. Photodynamic therapy effect on healing of radiation skin ulcer infected with pseudomonas aeruginosa [J]. Probl Radiac Med Radiobiol, 2017, 22: 202-207.
11
Miyabe M, Junqueira JC, Costa AC, et al. Effect of photodynamic therapy on clinical isolates of Staphylococcus spp [J]. Braz Oral Res, 2011, 25(3): 230-234.
12
Frade ML, de Annunzio SR, Calixto GMF, et al. Assessment of chitosan-based hydrogel and photodynamic inactivation against propionibacterium acnes [J]. Molecules, 2018, 23(2): E473.
13
Guffey JS, Payne W, Roegge W. In vitro fungicidal effects of methylene blue at 625-nm [J]. Mycoses, 2017, 60(11): 723-727.
14
López-Chicón P, Gulías Ò, Nonell S, et al. In vitro antimicrobial photodynamic therapy against trichophyton mentagrophytes using new methylene blue as the photosensitizer [J]. Actas Dermosifiliogr, 2016, 107(9): 765-770.
15
Munin E, Giroldo LM, Alves LP, et al. Study of germ tube formation by candida albicans after photodynamic antimicrobial chemotherapy (PACT) [J]. J Photochem Photobiol B, 2007, 88(1): 16-20.
16
Dai T, Bil de Arce VJ, Tegos GP, et al. Blue dye and red light, a dynamic combination for prophylaxis and treatment of cutaneous Candida albicans infections in mice [J]. Antimicrob Agents Chemother, 2011, 55(12): 5710-5717.
17
Li J, Zhu M, An L, et al. Fungicidal efficacy of photodynamic therapy using methylene blue against Sporothrix globosa in vitro and in vivo [J]. Eur J Dermatol, 2019, 29(2): 160-166.
18
do Nascimento Volpe RAF, Navasconi TR, Dos Reis VN, et al. Photodynamic therapy for the treatment of american tegumentary leishmaniasis: evaluation of therapies association in experimentally infected mice with leishmania (Leishmania) amazonensis [J]. J Lasers Med Sci, 2018 9(4): 274-282.
19
Fadel M, Salah M, Samy N, et al. Liposomal methylene blue hydrogel for selective photodynamic therapy of acne vulgaris [J]. J Drugs Dermatol, 2009, 8(11): 983-990.
20
Moftah NH, Ibrahim SM, Wahba NH. Intense pulsed light versus photodynamic therapy using liposomal methylene blue gel for the treatment of truncal acne vulgaris: a comparative randomized split body study [J]. Arch Dermatol Res, 2016, 308(4): 263-268.
21
Agut-Busquet E, Romaní J, Gilaberte Y, et al. Photodynamic therapy with intralesional methylene blue and a 635 nm light-emitting diode lamp in hidradenitis suppurativa: a retrospective follow-up study in 7 patients and a review of the literature [J]. Photochem Photobiol Sci, 2016, 15(8): 1020-1028.
22
Fadel MA, Tawfik AA. New topical photodynamic therapy for treatment of hidradenitis suppurativa using methylene blue niosomal gel: a single-blind, randomized, comparative study [J]. Clin Exp Dermatol, 2015, 40(2): 116-122.
23
Aspiroz C, Sevil M, Toyas C, et al. Photodynamic therapy with methylene blue for skin ulcers infected with pseudomonas aeruginosa and fusarium spp [J]. Actas Dermosifiliogr, 2017, 108(6): e45-e48.
24
Thomas J, Jacobson GA, Narkowicz CK, et al. Toenail onychomycosis: an important global disease burden [J]. J Clin Pharm Ther, 2010, 35(5): 497-519.
25
Souza LW, Souza SV, Botelho AC. Distal and lateral toenail onychomycosis caused by Trichophyton rubrum: treatment with photodynamic therapy based on methylene blue dye [J]. An Bras Dermatol, 2014, 89(1): 184-186.
26
Souza LW, Souza SV, Botelho AC. Endonyx toenail onychomycosis caused by Trichophyton rubrum: treatment with photodynamic therapy based on methylene blue dye [J]. An Bras Dermatol, 2013, 88(6): 1019-1021.
27
Figueiredo Souza LW, Souza SV, Botelho AC. Randomized controlled trial comparing photodynamic therapy based on methylene blue dye and fluconazole for toenail onychomycosis [J]. Dermatol Ther, 2014, 27(1): 43-47.
28
Robres P, Aspiroz C, Rezusta A, et al. Usefulness of photodynamic therapy in the management of onychomycosis [J]. Actas Dermosifiliogr, 2015, 106(10): 795-805.
29
Alberdi E, Gomez C. Efficiency of methylene blue-mediated photodynamic therapy vs intense pulsed light in the treatment of onychomycosis in the toenails [J]. Photodermatol Photoimmunol Photomed, 2019, 35(2): 69-77.
30
Scwingel AR, Barcessat AR, Nfinez SC. Antimicrobial photody namictherapy in thetreatmentoforalcan didiasisin HIV-infected patients [J].Photomed Laser Surg, 2012, 30(8): 429-432.
31
García-Malinis AJ, Milagro Beamonte A, Torres Sopena L, et al. Cutaneous sporotrichosis treated with methylene blue-daylight photodynamic therapy [J]. J Eur Acad Dermatol Venereol, 2018, 32(3): e90-e91.
32
Fathy G, Asaad MK, Rasheed HM. Rasheed, daylight photodynamic therapy with methylene blue in plane warts: a randomized double-blind placebo-controlled study [J]. Photodermatol Photoimmunol Photomed, 2017, 33(4): 185-192.
33
Marotti J, Aranha AC, Eduardo Cde P, et al. Photodynamic therapy can be effective as a treatment for herpes simplex labialis [J]. Photomed Laser Surg, 2009, 27(2): 357-363.
34
Song D, Lindoso JA, Oyafuso LK, et al. Photodynamic therapy using methylene blue to treat cutaneous leishmaniasis [J]. Photomed Laser Surg, 2011, 29(10): 711-715.
35
Zeina B, Greenman J, Corry D, et al. Antimicrobial photodynamic therapy: assessment of genotoxic effects on keratinocytes in vitro [J]. Br J Dermatol, 2003, 148(2): 229-232.
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