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中华临床医师杂志(电子版) ›› 2019, Vol. 13 ›› Issue (09) : 698 -701. doi: 10.3877/cma.j.issn.1674-0785.2019.09.012

所属专题: 文献

综述

亚甲蓝光动力治疗感染相关性皮肤病的研究进展
李婵婵1, 吴剑波1,()   
  1. 1. 430071 武汉大学中南医院皮肤科
  • 收稿日期:2019-04-05 出版日期:2019-05-01
  • 通信作者: 吴剑波

Progress in methylene blue mediated photodynamic therapy for infection-related skin diseases

Chanchan Li1, Jianbo Wu1,()   

  1. 1. Department of Dermatology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
  • Received:2019-04-05 Published:2019-05-01
  • Corresponding author: Jianbo Wu
  • About author:
    Corresponding author: Wu Jianbo, Email:
引用本文:

李婵婵, 吴剑波. 亚甲蓝光动力治疗感染相关性皮肤病的研究进展[J]. 中华临床医师杂志(电子版), 2019, 13(09): 698-701.

Chanchan Li, Jianbo Wu. Progress in methylene blue mediated photodynamic therapy for infection-related skin diseases[J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(09): 698-701.

亚甲蓝属吩噻嗪类衍生物,是光动力疗法中常用的光敏剂。体外研究已证实亚甲蓝光动力治疗(MB-PDT)可显著抑制或杀灭众多的致病细菌、真菌、病毒及原生生物。近年来,关于MB-PDT治疗感染性皮肤病的临床研究逐渐增多。现有的研究表明,MB-PDT对于多种感染相关性皮肤病具有肯定的治疗效果,且不良反应少、价格低廉,具有良好的应用前景。

Methylene blue belongs to a phenothiazine derivative that is a commonly used photosensitizer in photodynamic therapy (PDT). In vitro studies have confirmed that methylene blue mediated photodynamic therapy (MB-PDT) has significant inhibitory or killing effects on numerous pathogens like bacteria, fungi, viruses, and protists. In recent years, clinical studies on MB-PDT treatment for infection-associated skin diseases have gradually increased, and shown therapeutic effect on a variety of infection-associated skin diseases. Compared with other photosemsitizers, MB-PDT has less adverse reactions, lower prices, and good application prospects.

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