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中华临床医师杂志(电子版) ›› 2019, Vol. 13 ›› Issue (11) : 822 -827. doi: 10.3877/cma.j.issn.1674-0785.2019.11.005

所属专题: 文献

临床研究

18F-FDG PET/CT在结直肠癌术后血清癌胚抗原阳性患者中的临床应用
林新峰1, 李囡1, 王菲1, 赵伟1, 杨志1,()   
  1. 1. 100142 北京大学肿瘤医院核医学科
  • 收稿日期:2019-04-24 出版日期:2019-06-01
  • 通信作者: 杨志

Clinical value of 18F-FDG PET/CT in postoperative colorectal cancer patients with elevated serum carcinoembryonic antigen

Xinfeng Lin1, Nan Li1, Fei Wang1, Wei Zhao1, Zhi Yang1,()   

  1. 1. Department of Nuclear Medicine, Peking University Cancer Hospital, Beijing 100142, China
  • Received:2019-04-24 Published:2019-06-01
  • Corresponding author: Zhi Yang
  • About author:
    Corresponding author: Yang Zhi, E-mail:
引用本文:

林新峰, 李囡, 王菲, 赵伟, 杨志. 18F-FDG PET/CT在结直肠癌术后血清癌胚抗原阳性患者中的临床应用[J/OL]. 中华临床医师杂志(电子版), 2019, 13(11): 822-827.

Xinfeng Lin, Nan Li, Fei Wang, Wei Zhao, Zhi Yang. Clinical value of 18F-FDG PET/CT in postoperative colorectal cancer patients with elevated serum carcinoembryonic antigen[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(11): 822-827.

目的

探讨18F-FDG PET/CT检测结直肠癌术后血清癌胚抗原(CEA)阳性患者中复发和转移灶的价值。

方法

回顾性分析60例结直肠癌术后CEA阳性且接受PET/CT检查的患者,将PET/CT检出结果与病理及随访结果进行比较。

结果

18F-FDG PET/CT诊断阳性50例,假阳性1例;阴性10例,假阴性3例。PET/CT诊断结直肠癌术后CEA阳性患者复发和转移灶的灵敏度为94.2%(49/52),特异度为87.5%(7/8),阳性预测值为98.0%(49/50),阴性预测值为70.0%(7/10),准确率为93.3%(56/60)。

结论

18F-FDG PET/CT在结直肠癌术后血清CEA阳性患者中有较高的临床应用价值,其对复发及转移灶的检测具有较高的灵敏度、特异度及准确率。

Objective

To explore the value of 18-fluorine flurodeoxyglucose (18F-FDG) positron-emission tomography (PET)/computed tomography (CT) in detecting recurrence and metastasis in postoperative colorectal cancer patients with elevated serum carcinoembryonic antigen (CEA).

Methods

Clinical data of 60 cases of colorectal cancer, including PET/CT, pathological, and follow-up results, were analyzed retrospectively.

Results

There were 50 18F-FDG PET/CT positive and 10 18F-FDG PET/CT negative cases, including 1 false positive and 3 false negative cases. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 18F-FDG PET/CT in detecting recurrence and metastasis in postoperative colorectal cancer patients with elevated serum CEA were 94.2%(49/52), 87.5% (7/8), 98.0% (49/50), 70.0% (7/10), and 93.3% (56/60), respectively.

Conclusion

18F-FDG PET/CT has high clinical value in postoperative colorectal cancer patients with elevated serum CEA, and it has a high sensitivity, specificity, and accuracy in the detection of recurrence and metastasis.

表1 60例结直肠癌术后CEA升高患者的临床特征
图1 患者男,40岁,18F-FDG PET/CT图像 图a示患者右腹部造瘘口软组织灶轻度放射性摄取增高,判定为炎性改变;图b随访过程中,造瘘口软组织增大,考虑肿瘤转移
图2 患者女,51岁,18F-FDG PET/CT图像 图a示盆腔腹膜轻度放射性摄取增高(箭),判定为炎性改变;图b随访过程中腹膜较前增厚,放射性摄取较前增高(箭),考虑肿瘤转移
图3 患者男,77岁,18F-FDG PET/CT图像 图a示肠系膜根部小淋巴结(箭);图b示随访过程中发现淋巴结较前增大,放射性摄取较前增高(箭)
表2 18F-FDG PET/CT检查对结直肠癌术后CEA阳性患者复发及转移的诊断结果(例)
表3 18F-FDG PET/CT检出结直肠癌术后CEA阳性患者复发和转移病灶情况
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