切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2020, Vol. 14 ›› Issue (02) : 140 -143. doi: 10.3877/cma.j.issn.1674-0785.2020.02.013

所属专题: 文献

综述

抗磷脂抗体和子痫前期的研究进展
张晨露1, 蒋敏2, 罗健英2,()   
  1. 1. 116044 大连医科大学;225001 扬州,江苏省苏北人民医院妇产科
    2. 225009 扬州大学临床医学院;225001 扬州,江苏省苏北人民医院妇产科
  • 收稿日期:2019-10-10 出版日期:2020-02-15
  • 通信作者: 罗健英
  • 基金资助:
    江苏省妇幼健康科研项目(F201663)

Progress in research of antiphospholipid antibodies in preeclampsia

Chenlu Zhang1, Min Jiang2, Jianying Luo2,()   

  1. 1. Dalian Medical University, Dalian 116044, China; Department of Obstetrics and Gynecology, Subei People’s Hospital of Jiangsu Province, Yangzhou 225001, China
    2. Clinical Medical College, Yangzhou University, Yangzhou 225009, China; Department of Obstetrics and Gynecology, Subei People’s Hospital of Jiangsu Province, Yangzhou 225001, China
  • Received:2019-10-10 Published:2020-02-15
  • Corresponding author: Jianying Luo
  • About author:
    Corresponding author: Luo Jianying, Email:
引用本文:

张晨露, 蒋敏, 罗健英. 抗磷脂抗体和子痫前期的研究进展[J]. 中华临床医师杂志(电子版), 2020, 14(02): 140-143.

Chenlu Zhang, Min Jiang, Jianying Luo. Progress in research of antiphospholipid antibodies in preeclampsia[J]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(02): 140-143.

抗磷脂抗体是一类能与磷脂或磷脂结合蛋白结合的自身免疫性抗体,与血栓形成、不良孕产史密切相关。抗磷脂抗体中高滴度阳性的患者易有子痫前期等不良妊娠结局。子痫前期发生于妊娠期,可导致全身多脏器的损伤,严重危及母儿生命和健康。子痫前期的发病机制目前还不是很清楚,研究提示抗磷脂抗体可能通过诱导氧化应激,促进血管内炎症等作用参与子痫前期的发病;对于抗磷脂抗体阳性的患者,早期发现和早期干预对获得良好的妊娠结局至关重要。

Antiphospholipid antibodies are a class of autoimmune antibodies that bind to phospholipids or phospholipid-binding proteins and are closely related to thrombosis and poor maternal history. Patients with high levels of antiphospholipid antibodies are prone to adverse pregnancy outcomes such as preeclampsia. Preeclampsia occurs in pregnancy and can cause multiple organ damage with severe life-threatening complications in the mother and child. The pathogenesis of preeclampsia is still not clear. Studies suggest that antiphospholipid antibodies may participate in the pathogenesis of preeclampsia by inducing oxidative stress and promoting intravascular inflammation. Early detection and early intervention for patients with antiphospholipid antibodies are essential for achieving a good pregnancy outcome.

[1]
Gibbins KJ, Tebo AE, Nielsen SK, et al. Antiphospholipid antibodies in women with severe preeclampsia and placental insufficiency: a case-control study [J]. Lupus, 2018, 27(12): 1903-1910.
[2]
Heydarlou H, Eghabl-Fard S, Ahmadi M, et al. Investigation of follicular helper T cells, as a novel player, in preeclampsia [J]. J Cell Biochem, 2019, 120(3): 3845-3852.
[3]
Chaiworapongsa T, Chaemsaithong P, Yeo L, et al. Pre-eclampsia part 1: current understanding of its pathophysiology [J]. Nat Rev Nephrol, 2014, 10(8): 466-480.
[4]
谢幸,孔北华,段涛, 等. 妇产科学 [M]. 9版. 北京: 人民卫生出版社, 2018: 83-91.
[5]
Truong G, Guanzon D, Kinhal V, et al. Oxygen tension regulates the miRNA profile and bioactivity of exosomes released from extravillous trophoblast cells - Liquid biopsies for monitoring complications of pregnancy [J]. PLoS One, 2017, 12(3): e0174514.
[6]
Tong M, Johansson C, Xiao F, et al. Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia [J]. Sci Rep, 2017, 7(1): 16556.
[7]
Craici IM, Wagner SJ, Weissgerber TL, et al. Advances in the pathophysiology of pre-eclampsia and related podocyte injury [J]. Kidney Int, 2014, 86(2): 275-285.
[8]
Matsubara K, Higaki T, Matsubara Y, et al. Nitric Oxide and Reactive Oxygen Species in the Pathogenesis of Preeclampsia [J]. Int J Mol Sci, 2015, 16(3): 4600-4614.
[9]
Adu-Bonsaffoh K, Antwi DA, Gyan B, et al. Endothelial dysfunction in the pathogenesis of pre-eclampsia in Ghanaian women [J]. BMC Physiol, 2017, 17(1): 5.
[10]
Venkatesha S, Toporsian M, Lam C, et al. Soluble endoglin contributes to the pathogenesis of preeclampsia [J]. Nat Med, 2006, 12(6): 642-649.
[11]
Zeisler H, Llurba E, Chantraine FJ, et al. Soluble fms-like tyrosine kinase-1 to placental growth factor ratio: ruling out pre-eclampsia for up to 4 weeks and value of retesting [J]. Ultrasound Obstet Gynecol, 2019, 53(3): 367-375.
[12]
Kim MY, Buyon JP, Guerra MM, et al. Angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients with lupus and antiphospholipid antibodies: results of the PROMISSE study [J]. Am J Obstet Gynecol, 2016, 214(1): 108.e1-108.e14.
[13]
Mineo C. Inhibition of nitric oxide and antiphospholipid antibody-mediated thrombosis [J]. Curr Rheumatol Rep, 2013, 15(5): 324.
[14]
McCarthy FP, Kingdom JC, Kenny LC, et al. Animal models of preeclampsia; uses and limitations [J]. Placenta, 2011, 32(6): 413-419.
[15]
Erpenbeck L, Chowdhury CS, Zsengeller ZK, et al. PAD4 Deficiency Decreases Inflammation and Susceptibility to Pregnancy Loss in a Mouse Model [J]. Biol Reprod, 2016, 95(6): 132.
[16]
Giaglis S, Stoikou M, Grimolizzi F, et al. Neutrophil migration into the placenta: Good, bad or deadly? [J]. Cell Adhesion & Migration, 2016, 10(1-2): 208-225.
[17]
Lip SV, Boekschoten MV, Hooiveld GJ, et al. Early-onset preeclampsia, plasma microRNAs and endothelial cell function [J]. Am J Obstet Gynecol, 2019, 12(2): 98-106.
[18]
Perez-Sanchez C, Arias-de la Rosa I, Aguirre MA, et al. Circulating microRNAs as biomarkers of disease and typification of the atherothrombotic status in antiphospholipid syndrome [J]. Haematologica, 2018, 103(5): 908-918.
[19]
Yelnik CM, Laskin CA, Porter TF, et al. Lupus anticoagulant is the main predictor of adverse pregnancy outcomes in aPL-positive patients: validation of PROMISSE study results [J]. Lupus science & medicine, 2016, 3(1): e000131.
[20]
Lazzaroni MG, Andreoli L, Chighizola CB, et al. Risk factors for adverse pregnancy outcome in antiphospholipid antibodies carriers: Results from a multicenter italian cohort over 20 years of experience [J]. Ann Rheum Dis, 2017, 76(70): 1-70.
[21]
Do Prado AD, Piovesan DM, Staub HL, et al. Association of anticardiolipin antibodies with preeclampsia: a systematic review and meta-analysis [J]. Obstet Gynecol, 2010, 116(6): 1433-1443.
[22]
Ferrer-Oliveras R, Llurba E, Cabero-Roura L, et al. Prevalence and clinical usefulness of antiphospholipid and anticofactor antibodies in different Spanish preeclampsia subsets [J]. Lupus, 2012, 21(3): 257-263.
[23]
Ding X, Yang Z, Han Y, et al. Long-chain fatty acid oxidation changes in a beta2 glycoprotein I-induced preeclampsia-like mouse model [J]. Placenta, 2014, 35(6): 392-397.
[24]
Skeith L, Abou-Nassar KE, Walker M, et al. Are Anti-2 Glycoprotein 1 Antibodies Associated with Placenta-Mediated Pregnancy Complications? A Nested Case-Control Study [J]. Am J Perinatol, 2018, 35(11): 1093-1099.
[25]
张文. 抗磷脂综合征治疗进展 [J]. 中国实用内科杂志, 2017, 37(2): 120-123.
[26]
Rolnik DL, Wright D, Poon LC, et al. Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia [J]. N Engl J Med, 2017, 377(7): 613-622.
[27]
Rolnik DL, O′Gorman N, Roberge S, et al. Early screening and prevention of preterm pre-eclampsia with aspirin: time for clinical implementation [J]. Ultrasound Obstet Gynecol, 2017, 50(5): 551-556.
[28]
Roberge S, Nicolaides K, Demers S, et al. The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis [J]. Am J Obstet Gynecol, 2017, 216(2): 110-20. e6.
[29]
马晓彬. 低剂量阿司匹林预防高危孕妇子病前期的临床价值 [J]. 中国医药指南, 2019, 17(7): 79-80.
[30]
McLaughlin K, Baczyk D, Potts A, et al. Low Molecular Weight Heparin Improves Endothelial Function in Pregnant Women at High Risk of Preeclampsia [J]. Hypertension, 2017, 69(1): 180-188.
[31]
Roberge S, Demers S, Nicolaides KH, et al. Prevention of pre-eclampsia by low-molecular-weight heparin in addition to aspirin: a meta-analysis [J]. Ultrasound Obstet Gynecol, 2016, 47(5): 548-553.
[32]
Lecarpentier E, Gris JC, Cochery-Nouvellon E, et al. Angiogenic Factor Profiles in Pregnant Women With a History of Early-Onset Severe Preeclampsia Receiving Low-Molecular-Weight Heparin Prophylaxis [J]. Obstet Gynecol, 2018, 131(1): 63-69.
[33]
Van Hoorn ME, Hague WM, van Pampus MG, et al. Low-molecular-weight heparin and aspirin in the prevention of recurrent early-onset pre-eclampsia in women with antiphospholipid antibodies: the FRUIT-RCT [J]. Eur J Obstet Gynecol Reprod Biol, 2016, 197: 168-173.
[34]
Groom KM, McCowan LM, Mackay LK, et al. Enoxaparin for the prevention of preeclampsia and intrauterine growth restriction in women with a history: a randomized trial [J]. Am J Obstet Gynecol, 2017, 216(3): 296. e1-e14.
[35]
Alijotas-Reig J, Esteve-Valverde E, Ferrer-Oliveras R, et al. The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): A survey of 1000 consecutive cases [J]. Autoimmun Rev, 2019, 18(4): 406-414.
[36]
Schreiber K, Breen K, Cohen H, et al. HYdroxychloroquine to Improve Pregnancy Outcome in Women with AnTIphospholipid Antibodies (HYPATIA) Protocol: A Multinational Randomized Controlled Trial of Hydroxychloroquine versus Placebo in Addition to Standard Treatment in Pregnant Women with Antiphospholipid Syndrome or Antibodies [J]. Semin Thromb Hemost, 2017, 43(6): 562-571.
[37]
Lefkou E, Mamopoulos A, Dagklis T, et al. Pravastatin improves pregnancy outcomes in obstetric antiphospholipid syndrome refractory to antithrombotic therapy [J]. J Clin Invest, 2016, 126(8): 2933-2940.
[38]
Xu J, Jia X, Gu Y, et al. Vitamin D Reduces Oxidative Stress-Induced Procaspase-3/ROCK1 Activation and MP Release by Placental Trophoblasts [J]. J Clin Endocrinol Metab, 2017, 102(6): 2100-2110.
[39]
Burke SD, Zsengellér ZK, Khankin EV, et al. Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia [J]. J Clin Invest, 2016, 126(7): 2561-2574.
[1] 贺敬龙, 孙炜, 高明宏, 谢伟, 姜骆永, 何琦非, 岳家吉. 外泌体非编码RNA在骨关节炎发病机制中的研究进展[J]. 中华关节外科杂志(电子版), 2023, 17(04): 520-527.
[2] 周东杰, 蒋敏, 范海瑞, 高玲玲, 孔祥, 卢丹, 王丽萍. 非编码RNA在卵泡发育成熟中作用及其机制的研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(04): 387-393.
[3] 娄丽丽, 刘瀚旻. 儿童哮喘易感基因及表观遗传学研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(03): 249-255.
[4] 郝耀, 陈丽, 韩永斌, 高宏, 韩树峰. miRNA在骨骼生长发育和骨性关节炎中的作用[J]. 中华损伤与修复杂志(电子版), 2023, 18(01): 73-77.
[5] 尹娟, 杨兴, 李平, 徐旻馨, 鲍玉, 张志鹏, 薛慧. 低强度脉冲式超声波在脂多糖诱导的RAW264.7巨噬细胞分化中的抗炎和抗氧化作用[J]. 中华口腔医学研究杂志(电子版), 2023, 17(01): 26-36.
[6] 钟轼, 李斌飞, 温君琳, 古晨, 廖小卒. 右美托咪定缓解神经病理性疼痛作用机制的研究进展[J]. 中华普通外科学文献(电子版), 2023, 17(03): 237-240.
[7] 刘骏, 朱霁, 殷骏. 右美托咪定对腹股沟疝手术麻醉效果及安全性的影响[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(05): 570-573.
[8] 王楚风, 蒋安. 原发性肝癌的分子诊断[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 499-503.
[9] 尚慧娟, 袁晓冬. 机械取栓术后应用依达拉奉右崁醇对急性缺血性脑卒中预后的改善[J]. 中华神经创伤外科电子杂志, 2023, 09(05): 295-301.
[10] 阿迪莱·阿卜杜热西提, 费奥, 邢晓雯, 谢胜强, 张睿, 兰晓娟, 程岗. 三种模拟创伤性脑损伤体外细胞模型的损伤特征比较[J]. 中华神经创伤外科电子杂志, 2023, 09(02): 69-75.
[11] 邹勇, 顾应江, 丁昊, 杨呈浩, 陈岷辉, 蔡昱. 基于Nrf2/HO-1及NF-κB信号通路探讨葛根素对大鼠脑出血后早期炎症反应及氧化应激反应的影响[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(05): 271-277.
[12] 张敏洁, 张小杉, 段莎莎, 施依璐, 赵捷, 白天昊, 王雅晳. 氢气治疗心肌缺血再灌注损伤的作用机制及展望[J]. 中华临床医师杂志(电子版), 2023, 17(06): 744-748.
[13] 孙凤兰, 周萍, 程兴璞, 张倩倩. 腹腔镜全子宫切除术对子宫肌瘤患者机体氧化应激损伤及术后并发症的影响[J]. 中华临床医师杂志(电子版), 2023, 17(02): 149-153.
[14] 岑妍慧, 高月, 林江, 刘鹏, 贾微, 杨瑞, 黄威, 刘鑫, 黄泽萍, 宁志莹. 水解南珠液通过Wnt/β-catenin通路调节细胞自噬对人微血管内皮细胞氧化应激损伤的影响[J]. 中华临床医师杂志(电子版), 2023, 17(01): 72-79.
[15] 买买提·依斯热依力, 依力汗·依明, 王永康, 阿巴伯克力·乌斯曼, 艾克拜尔·艾力, 李义亮, 克力木·阿不都热依木. 氧化应激对3T3-L1前脂肪细胞中GLP-1/DPP-4信号通路以及炎症因子表达的影响[J]. 中华肥胖与代谢病电子杂志, 2023, 09(03): 186-191.
阅读次数
全文


摘要