切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2020, Vol. 14 ›› Issue (02) : 140 -143. doi: 10.3877/cma.j.issn.1674-0785.2020.02.013

所属专题: 文献

综述

抗磷脂抗体和子痫前期的研究进展
张晨露1, 蒋敏2, 罗健英2,()   
  1. 1. 116044 大连医科大学;225001 扬州,江苏省苏北人民医院妇产科
    2. 225009 扬州大学临床医学院;225001 扬州,江苏省苏北人民医院妇产科
  • 收稿日期:2019-10-10 出版日期:2020-02-15
  • 通信作者: 罗健英
  • 基金资助:
    江苏省妇幼健康科研项目(F201663)

Progress in research of antiphospholipid antibodies in preeclampsia

Chenlu Zhang1, Min Jiang2, Jianying Luo2,()   

  1. 1. Dalian Medical University, Dalian 116044, China; Department of Obstetrics and Gynecology, Subei People’s Hospital of Jiangsu Province, Yangzhou 225001, China
    2. Clinical Medical College, Yangzhou University, Yangzhou 225009, China; Department of Obstetrics and Gynecology, Subei People’s Hospital of Jiangsu Province, Yangzhou 225001, China
  • Received:2019-10-10 Published:2020-02-15
  • Corresponding author: Jianying Luo
  • About author:
    Corresponding author: Luo Jianying, Email:
引用本文:

张晨露, 蒋敏, 罗健英. 抗磷脂抗体和子痫前期的研究进展[J/OL]. 中华临床医师杂志(电子版), 2020, 14(02): 140-143.

Chenlu Zhang, Min Jiang, Jianying Luo. Progress in research of antiphospholipid antibodies in preeclampsia[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(02): 140-143.

抗磷脂抗体是一类能与磷脂或磷脂结合蛋白结合的自身免疫性抗体,与血栓形成、不良孕产史密切相关。抗磷脂抗体中高滴度阳性的患者易有子痫前期等不良妊娠结局。子痫前期发生于妊娠期,可导致全身多脏器的损伤,严重危及母儿生命和健康。子痫前期的发病机制目前还不是很清楚,研究提示抗磷脂抗体可能通过诱导氧化应激,促进血管内炎症等作用参与子痫前期的发病;对于抗磷脂抗体阳性的患者,早期发现和早期干预对获得良好的妊娠结局至关重要。

Antiphospholipid antibodies are a class of autoimmune antibodies that bind to phospholipids or phospholipid-binding proteins and are closely related to thrombosis and poor maternal history. Patients with high levels of antiphospholipid antibodies are prone to adverse pregnancy outcomes such as preeclampsia. Preeclampsia occurs in pregnancy and can cause multiple organ damage with severe life-threatening complications in the mother and child. The pathogenesis of preeclampsia is still not clear. Studies suggest that antiphospholipid antibodies may participate in the pathogenesis of preeclampsia by inducing oxidative stress and promoting intravascular inflammation. Early detection and early intervention for patients with antiphospholipid antibodies are essential for achieving a good pregnancy outcome.

[1]
Gibbins KJ, Tebo AE, Nielsen SK, et al. Antiphospholipid antibodies in women with severe preeclampsia and placental insufficiency: a case-control study [J]. Lupus, 2018, 27(12): 1903-1910.
[2]
Heydarlou H, Eghabl-Fard S, Ahmadi M, et al. Investigation of follicular helper T cells, as a novel player, in preeclampsia [J]. J Cell Biochem, 2019, 120(3): 3845-3852.
[3]
Chaiworapongsa T, Chaemsaithong P, Yeo L, et al. Pre-eclampsia part 1: current understanding of its pathophysiology [J]. Nat Rev Nephrol, 2014, 10(8): 466-480.
[4]
谢幸,孔北华,段涛, 等. 妇产科学 [M]. 9版. 北京: 人民卫生出版社, 2018: 83-91.
[5]
Truong G, Guanzon D, Kinhal V, et al. Oxygen tension regulates the miRNA profile and bioactivity of exosomes released from extravillous trophoblast cells - Liquid biopsies for monitoring complications of pregnancy [J]. PLoS One, 2017, 12(3): e0174514.
[6]
Tong M, Johansson C, Xiao F, et al. Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia [J]. Sci Rep, 2017, 7(1): 16556.
[7]
Craici IM, Wagner SJ, Weissgerber TL, et al. Advances in the pathophysiology of pre-eclampsia and related podocyte injury [J]. Kidney Int, 2014, 86(2): 275-285.
[8]
Matsubara K, Higaki T, Matsubara Y, et al. Nitric Oxide and Reactive Oxygen Species in the Pathogenesis of Preeclampsia [J]. Int J Mol Sci, 2015, 16(3): 4600-4614.
[9]
Adu-Bonsaffoh K, Antwi DA, Gyan B, et al. Endothelial dysfunction in the pathogenesis of pre-eclampsia in Ghanaian women [J]. BMC Physiol, 2017, 17(1): 5.
[10]
Venkatesha S, Toporsian M, Lam C, et al. Soluble endoglin contributes to the pathogenesis of preeclampsia [J]. Nat Med, 2006, 12(6): 642-649.
[11]
Zeisler H, Llurba E, Chantraine FJ, et al. Soluble fms-like tyrosine kinase-1 to placental growth factor ratio: ruling out pre-eclampsia for up to 4 weeks and value of retesting [J]. Ultrasound Obstet Gynecol, 2019, 53(3): 367-375.
[12]
Kim MY, Buyon JP, Guerra MM, et al. Angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients with lupus and antiphospholipid antibodies: results of the PROMISSE study [J]. Am J Obstet Gynecol, 2016, 214(1): 108.e1-108.e14.
[13]
Mineo C. Inhibition of nitric oxide and antiphospholipid antibody-mediated thrombosis [J]. Curr Rheumatol Rep, 2013, 15(5): 324.
[14]
McCarthy FP, Kingdom JC, Kenny LC, et al. Animal models of preeclampsia; uses and limitations [J]. Placenta, 2011, 32(6): 413-419.
[15]
Erpenbeck L, Chowdhury CS, Zsengeller ZK, et al. PAD4 Deficiency Decreases Inflammation and Susceptibility to Pregnancy Loss in a Mouse Model [J]. Biol Reprod, 2016, 95(6): 132.
[16]
Giaglis S, Stoikou M, Grimolizzi F, et al. Neutrophil migration into the placenta: Good, bad or deadly? [J]. Cell Adhesion & Migration, 2016, 10(1-2): 208-225.
[17]
Lip SV, Boekschoten MV, Hooiveld GJ, et al. Early-onset preeclampsia, plasma microRNAs and endothelial cell function [J]. Am J Obstet Gynecol, 2019, 12(2): 98-106.
[18]
Perez-Sanchez C, Arias-de la Rosa I, Aguirre MA, et al. Circulating microRNAs as biomarkers of disease and typification of the atherothrombotic status in antiphospholipid syndrome [J]. Haematologica, 2018, 103(5): 908-918.
[19]
Yelnik CM, Laskin CA, Porter TF, et al. Lupus anticoagulant is the main predictor of adverse pregnancy outcomes in aPL-positive patients: validation of PROMISSE study results [J]. Lupus science & medicine, 2016, 3(1): e000131.
[20]
Lazzaroni MG, Andreoli L, Chighizola CB, et al. Risk factors for adverse pregnancy outcome in antiphospholipid antibodies carriers: Results from a multicenter italian cohort over 20 years of experience [J]. Ann Rheum Dis, 2017, 76(70): 1-70.
[21]
Do Prado AD, Piovesan DM, Staub HL, et al. Association of anticardiolipin antibodies with preeclampsia: a systematic review and meta-analysis [J]. Obstet Gynecol, 2010, 116(6): 1433-1443.
[22]
Ferrer-Oliveras R, Llurba E, Cabero-Roura L, et al. Prevalence and clinical usefulness of antiphospholipid and anticofactor antibodies in different Spanish preeclampsia subsets [J]. Lupus, 2012, 21(3): 257-263.
[23]
Ding X, Yang Z, Han Y, et al. Long-chain fatty acid oxidation changes in a beta2 glycoprotein I-induced preeclampsia-like mouse model [J]. Placenta, 2014, 35(6): 392-397.
[24]
Skeith L, Abou-Nassar KE, Walker M, et al. Are Anti-2 Glycoprotein 1 Antibodies Associated with Placenta-Mediated Pregnancy Complications? A Nested Case-Control Study [J]. Am J Perinatol, 2018, 35(11): 1093-1099.
[25]
张文. 抗磷脂综合征治疗进展 [J]. 中国实用内科杂志, 2017, 37(2): 120-123.
[26]
Rolnik DL, Wright D, Poon LC, et al. Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia [J]. N Engl J Med, 2017, 377(7): 613-622.
[27]
Rolnik DL, O′Gorman N, Roberge S, et al. Early screening and prevention of preterm pre-eclampsia with aspirin: time for clinical implementation [J]. Ultrasound Obstet Gynecol, 2017, 50(5): 551-556.
[28]
Roberge S, Nicolaides K, Demers S, et al. The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis [J]. Am J Obstet Gynecol, 2017, 216(2): 110-20. e6.
[29]
马晓彬. 低剂量阿司匹林预防高危孕妇子病前期的临床价值 [J]. 中国医药指南, 2019, 17(7): 79-80.
[30]
McLaughlin K, Baczyk D, Potts A, et al. Low Molecular Weight Heparin Improves Endothelial Function in Pregnant Women at High Risk of Preeclampsia [J]. Hypertension, 2017, 69(1): 180-188.
[31]
Roberge S, Demers S, Nicolaides KH, et al. Prevention of pre-eclampsia by low-molecular-weight heparin in addition to aspirin: a meta-analysis [J]. Ultrasound Obstet Gynecol, 2016, 47(5): 548-553.
[32]
Lecarpentier E, Gris JC, Cochery-Nouvellon E, et al. Angiogenic Factor Profiles in Pregnant Women With a History of Early-Onset Severe Preeclampsia Receiving Low-Molecular-Weight Heparin Prophylaxis [J]. Obstet Gynecol, 2018, 131(1): 63-69.
[33]
Van Hoorn ME, Hague WM, van Pampus MG, et al. Low-molecular-weight heparin and aspirin in the prevention of recurrent early-onset pre-eclampsia in women with antiphospholipid antibodies: the FRUIT-RCT [J]. Eur J Obstet Gynecol Reprod Biol, 2016, 197: 168-173.
[34]
Groom KM, McCowan LM, Mackay LK, et al. Enoxaparin for the prevention of preeclampsia and intrauterine growth restriction in women with a history: a randomized trial [J]. Am J Obstet Gynecol, 2017, 216(3): 296. e1-e14.
[35]
Alijotas-Reig J, Esteve-Valverde E, Ferrer-Oliveras R, et al. The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): A survey of 1000 consecutive cases [J]. Autoimmun Rev, 2019, 18(4): 406-414.
[36]
Schreiber K, Breen K, Cohen H, et al. HYdroxychloroquine to Improve Pregnancy Outcome in Women with AnTIphospholipid Antibodies (HYPATIA) Protocol: A Multinational Randomized Controlled Trial of Hydroxychloroquine versus Placebo in Addition to Standard Treatment in Pregnant Women with Antiphospholipid Syndrome or Antibodies [J]. Semin Thromb Hemost, 2017, 43(6): 562-571.
[37]
Lefkou E, Mamopoulos A, Dagklis T, et al. Pravastatin improves pregnancy outcomes in obstetric antiphospholipid syndrome refractory to antithrombotic therapy [J]. J Clin Invest, 2016, 126(8): 2933-2940.
[38]
Xu J, Jia X, Gu Y, et al. Vitamin D Reduces Oxidative Stress-Induced Procaspase-3/ROCK1 Activation and MP Release by Placental Trophoblasts [J]. J Clin Endocrinol Metab, 2017, 102(6): 2100-2110.
[39]
Burke SD, Zsengellér ZK, Khankin EV, et al. Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia [J]. J Clin Invest, 2016, 126(7): 2561-2574.
[1] 刘伟, 牛云峰, 安杰. LINC01232 通过miR-516a-5p/BCL9 轴促进三阴性乳腺癌的恶性进展[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 330-338.
[2] 于溟璇, 杜华, 张彩虹, 师迎旭. miRNA-192家族在乳腺癌中的作用机制及诊断价值[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(04): 235-240.
[3] 费一鸣, 刘卓, 张丽娟. 组学分析在早产分子机制中的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 504-510.
[4] 魏艺, 周羽西, 杨烨, 凌秀凤, 赵纯. 微小RNA对子宫内膜容受性影响的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(03): 266-270.
[5] 奚卫, 王闻卿, 刘玥, 王亚楠, 许学斌. 胃肠炎继发脓毒症感染创伤弧菌ST14514的病原学诊断与文献病例回顾分析[J/OL]. 中华实验和临床感染病杂志(电子版), 2024, 18(05): 293-302.
[6] 李嘉兴, 孙乙文, 李文星. NLRP3炎性小体在急性胰腺炎中作用的研究进展[J/OL]. 中华普通外科学文献(电子版), 2024, 18(04): 300-304.
[7] 张璇, 高杨, 房雅君, 姚艳玲. 保护性机械通气在肺癌胸腔镜肺段切除术中的临床应用[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 563-567.
[8] 殷国青, 曾莉, 贺斌峰, 孙芬芬. Rab26负性调控Nrf2增强肺癌耐药细胞对奥希替尼的敏感性[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(03): 349-355.
[9] 杜霞, 马梦青, 曹长春. 造影剂诱导的急性肾损伤的发病机制及干预靶点研究进展[J/OL]. 中华肾病研究电子杂志, 2024, 13(05): 279-282.
[10] 李佳曦, 刘子源, 李学民. 二甲双胍对年龄相关性白内障影响的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(04): 252-256.
[11] 王子琪, 李萍, 蔡标, 杨秀敏. 雌激素在糖尿病性视网膜病变中作用机制的研究进展[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(03): 187-192.
[12] 李京, 牛博, 刘晓蓓, 魏新雪, 黄荣. circ-SESN2 沉默靶向调控miRNA-23a-5p/ULK1 在神经细胞氧化应激损伤中的作用机制研究[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(05): 263-272.
[13] 冯铭, 孙洪涛. 动脉瘤性蛛网膜下腔出血的颅内压监测与管理[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(04): 248-253.
[14] 张晟豪, 周杰, 姚鹏飞, 李长栋, 屈晓东, 南亚强, 曹丽. 雷公藤红素在创伤性脑损伤后继发性损伤中的作用及机制研究[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(03): 132-140.
[15] 买买提·依斯热依力, 尹强, 尹海龙, 李治建, 董雨微, 王永康, 克力木·阿不都热依木, 阿吉艾克拜尔·艾萨. 罗乐胃蜜膏抑制酸刺激诱导食管上皮细胞炎症发生的机制研究[J/OL]. 中华胃食管反流病电子杂志, 2024, 11(03): 137-142.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?