切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2020, Vol. 14 ›› Issue (05) : 385 -390. doi: 10.3877/cma.j.issn.1674-0785.2020.05.013

所属专题: 文献

综述

经血来源干细胞临床应用研究进展
程贤鹦1,(), 周锦红1   
  1. 1. 310030 杭州,浙江医院妇产科
  • 收稿日期:2019-11-12 出版日期:2020-05-15
  • 通信作者: 程贤鹦
  • 基金资助:
    浙江省中医药管理局(2018ZB008)

Progress in clinical application of menstrual blood-derived stem cells

Xianying Cheng1,(), Jinhong Zhou1   

  1. 1. Department of Gynecology and Obstetrics, Zhejiang Hospital, Hangzhou 310030, China
  • Received:2019-11-12 Published:2020-05-15
  • Corresponding author: Xianying Cheng
  • About author:
    Corresponding author: Cheng Xianying, Email:
引用本文:

程贤鹦, 周锦红. 经血来源干细胞临床应用研究进展[J/OL]. 中华临床医师杂志(电子版), 2020, 14(05): 385-390.

Xianying Cheng, Jinhong Zhou. Progress in clinical application of menstrual blood-derived stem cells[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2020, 14(05): 385-390.

经血来源干细胞是一种经血来源的间充质干细胞,具有来源丰富、无创获取、易分离培养、增殖率高、传代次数较多、低免疫原性、无伦理争议等独特优势,目前被广泛用于各种疾病治疗的研究中,表现出良好的治疗潜力,临床应用前景广阔。但在经血来源干细胞成为临床常规治疗前,仍有很多问题亟待解决,现将经血来源干细胞的临床应用进展综述如下。

Menstrual blood stem-derived cells are mesenchymal stem cells derived from menstrual blood. They have the advantages of abundant source, non-invasive acquisition, easy isolation and culture, high proliferation rate, high number of passages, low immunogenicity, and no ethical controversy. In the treatment of various diseases, menstrual blood stem-derived cells show a good therapeutic potential and have broad clinical application prospects. However, there are still many problems to be solved before they become a clinical routine treatment.

表1 6种间充质干细胞来源特性比较
1
Meng X, Ichim TE, Zhong J, et al. Endometrial regenerative cells: A novel stem cell population [J]. J Transl Med, 2007, 5: 57-66.
2
Cui CH, Uyama T, Miyado K, et al. Menstrual blood-derived cells confer human dystrophin expression in the model of Duchenne muscular dystrophy via cell fusion and myogenic transdifferentiation [J]. Molecular Biology of the Cell, 2007, 18: 1586-1594.
3
Liu YL, Niu CR, Yang F, et al. Biological characteristics of human menstrual blood-derived endometrial stem cells [J]. J Cell Mol Med, 2018, 22(3): 1627-1639.
4
Lv h, Hu YL, Cui ZF, et al. Human menstrual blood: a renewable and sustainable source of stem cells for regenerative medicine stem cell [J].Research & Therapy, 2018, 9: 325.
5
Borlongan CV, Kaneko Y, Maki M, et al. Menstrual blood cells display stem cell-like phenotypic markers and exert neuroprotection following transplantation in experimental stroke [J]. Stem Cells Dev, 2010, 19: 439-452.
6
Nikoo S, Ebtekar M, Jeddi-Tehrani M, et al. Menstrual blood-derived stromal stem cells from women with and without endometriosis reveal different phenotypic and functional characteristics [J]. Mol Hum Reprod, 2014, 20: 905-918.
7
Chen LJ, Qu JJ, Xian CL. The multi-functional roles of menstrual blood-derived stem cells in regenerative medicine Stem [J]. Cell Research & Therapy, 2019, 10: 1.
8
Wu X, Luo Y, Chen J, et al. Transplantation of human menstrual blood progenitor cells improves hyperglycemia by promoting endogenous progenitor differentiation in type 1 diabetic mice [J]. Stem Cells Dev, 2014, 23: 1245-1257.
9
Chen J, Du X, Chen Q, et al. Effects of donors′age and passage number on the biological characteristics of menstrual blood-derived stem cells [J]. Int J Clin Exp Pathol, 2015, 8(11): 14584-14595.
10
Liu T, Huang Y, Zhang J, et al. Transplantation of human menstrual blood stem cells to treat premature ovarian failure in mouse model [J]. Stem Cells and Development, 2014, 23: 1548-1557.
11
Hida N, Nishiyama N, Miyoshi S, et al. Novel cardiac precursor-like cells from human menstrual blood-derived mesenchymal cells [J]. Stem Cells, 2008, 26: 1695-1704.
12
Zheng SX, Wang J, Wang XL, et al. Feasibility analysis of treating severe intrauterine adhesions by transplanting menstrual blood-derived stem cells [J]. Int J Mol Med, 2018, 41(4): 2201-2212.
13
Lai D, Guo Y, Zhang Q, et al. Differentiation of human menstrual blood-derived endometrial mesenchymal stem cells into oocyte-like cells [J]. Acta Biochim Biophys Sin, 2016, 48: 998-1005.
14
Chen L, Zhang C, Chen L, et al. Human menstrual blood-derived stem cells ameliorate liver fibrosis in mice by targeting hepatic stellate cells via paracrine mediators [J]. Stem Cells Transl Med, 2017, 6: 272-684.
15
Wang F, Yao X, Zhao Y, et al. Human endometrial mesenchymal stem cells restore ovarian function through improving the renewal of germline stem cells in a mouse model of premature ovarian failure [J]. J Transl Med, 2015, 13: 155.
16
Masuda H, Anwar SS, Bühring HJ, et al. A novel marker of human endometrial mesenchymal stem-like cells [J]. Cell Transpl, 2012, 21(10): 2201-2214.
17
Peron JPS, Jazedje T, Brandao WN, et al. Human endometrial-derived mesenchymal stem cells suppress inflammation in the central nervous system of EAE mice [J]. Stem Cell Rev Rep, 2012, 8(3): 940-952.
18
Bozorgmehr M, Moazzeni SM, Salehnia M, et al. Menstrual blood-derived stromal stem cells inhibit optimal generation and maturation of human monocyte-derived dendritic cells [J]. Immunol Lett, 2014, 162: 239-246.
19
Murphy MP, Wang H, Patel AN, et al. Allogeneic endometrial regenerative cells: an "Off the shelf solution" for critical limb ischemia? [J]. J Trans Med, 2008, 6: 45.
20
Jiang Z, Hu X, Yu H, et al. Human endometrial stem cells confer enhanced myocardial salvage and regeneration by paracrine mechanisms [J]. J Cell Mol Med, 2013, 17(10): 1247-1260.
21
Zhang Z, Wang JA, Xu Y, et al. Menstrual blood derived mesenchymal mesenchymal cells ameliorate cardiac fibrosis via inhibition of endothelial to transition in myocardial infarction [J]. Intern J Cardiol, 2013, 168: 1711-1714.
22
Wang K, Jiang Z, Webster KA, et al. Enhanced cardioprotection by human endometrium mesenchymal stem cells driven by exosomal MicroRNA-21 [J]. Stem Cells Transl Med, 2017, 6: 209-222.
23
Ichim TE, Solano F, Lara F, et al. Combination stem cell therapy for heart failure [J]. Int Arch Med, 2010, 3: 5.
24
Lan X, Wang G, Xu X, et al. Stromal cell-derived factor-1 mediates cardiac allograft tolerance induced by human endometrial regenerative cell-based therapy [J]. Stem Cells Transl Med, 2017, 6(11): 1997-2008.
25
Xiang B, Chen L, Wang X, et al. Transplantation of menstrual blood-derived mesenchymal stem cells promotes the repair of LPS-induced acute lunginjury [J]. Int J Mol Sci, 2017, 18: 689.
26
Chen L, Xiang B, Wang X, et al. Exosomes derived from human menstrual blood-derived stem cells alleviate fulminant hepatic failure [J]. Stem Cell Res Ther, 2017, 8: 9.
27
Zhao Y, Chen X, Wu Y, et al. Transplantation of human menstrual blood-derived mesenchymal stem cells alleviates Alzheimer′s disease-like pathology in APP/PS1 transgenic mice [J]. Front Mol Neurosci, 2018, 11: 140.
28
Ichim TE, Alexandrescu DT, Solano F, et al. Mesenchymal stem cells as anti-inflammatories: implications for treatment of Duchenne muscular dystrophy [J]. Cell Immunol, 2010, 260(2): 75-82.
29
Lai D, Wang F, Yao X, et al. Human endometrial mesenchymal stem cells restore ovarian function through improving the renewal of germline stem cells in a mouse model of premature ovarian failure [J]. J Transl Med, 2015, 13: 155.
30
Wang Z, Wang Y, Yang T, et al. Study of the reparative effects of menstrual-derived stem cells on premature ovarian failure in mice [J]. Stem Cell Res Ther, 2017, 8: 11.
31
Hu J, Song KY, hang J, et al. Effects of menstrual blood derived stem cells on endometrial injury repair [J]. Molecular Medicine Reports, 2018, 19(2): 813-820.
32
Zhang Y, Lin X, Dai Y, et al. Endometrial stem cells repair injured endometrium and induce angiogenesis via AKT and ERK pathways [J]. Reproduction, 2016, 152: 389-402.
33
Zhu HY, Jiang YS, Pan YB, et al.Human menstrual blood-derived stem cells promote the repair of impaired endometrial stromal cells by activating the p38 MAPK and AKT signaling pathways [J].Reproductive Biology, 2018, 18: 274-281.
34
Tan J, Li P, Wang Q, et al. Autologous menstrual blood-derived stromal cells transplantation for severe Ashermans syndrome [J]. Hum Reprod, 2016, 31: 2723-2729.
35
Ulrich D, Edwards SL, Su K, et al. Human endometrial mesenchymal stem cells modulate the tissue response and mechanical behavior of polyamide mesh implants for pelvic organ prolapse repair [J]. Tissue Eng Part A, 2014, 20: 785-798.
36
Cuenca J, Le-Gatt A, Castillo V, et al. The reparative abilities of menstrual stem cells modulate the wound matrix signals and improve cutaneous regeneration [J]. Front Physiol, 2018, 9: 464.
37
Wang XJ, Xiang BY, Ding YH, et al. Human menstrual blood-derived mesenchymal stem cells as a cellular vehicle for malignant glioma gene therapy [J]. Oncotarget, 2017, 8: 58309-58321.
[1] 何甘霖, 陈香侬, 李萍, 甄佳怡, 李京霞, 邹外一, 许多荣. 白血病异基因造血干细胞移植术后股骨坏死的影响因素[J/OL]. 中华关节外科杂志(电子版), 2024, 18(04): 450-456.
[2] 刘云, 时月, 郭冬梅, 邱志远, 王丽娟, 冉学红, 李乾鹏. 造血干细胞移植治疗伴有胚系突变的髓系肿瘤患者三例并文献复习[J/OL]. 中华移植杂志(电子版), 2024, 18(04): 230-234.
[3] 朴美英, 刘娜, 孟繁峥, 李春艳. 支气管镜诊断儿童造血干细胞移植后闭塞性细支气管炎综合征二例[J/OL]. 中华移植杂志(电子版), 2024, 18(02): 116-119.
[4] 刘麾, 赵鹏, 冯静, 胡晓彦, 杜涛, 王凌云. 三维调强放射治疗对急性髓系白血病异基因造血干细胞移植后髓外复发的疗效观察[J/OL]. 中华移植杂志(电子版), 2024, 18(02): 110-115.
[5] 李赞, 许芝彬, 冯志金, 张雄. 重型β-地中海贫血患儿异基因造血干细胞移植后淋巴细胞亚群动态分析[J/OL]. 中华移植杂志(电子版), 2024, 18(01): 22-29.
[6] 张心怡, 吕军好, 陈大进. 2023年肾移植领域研究进展[J/OL]. 中华移植杂志(电子版), 2024, 18(01): 7-11.
[7] 孔欣, 宋宝全, 刘吟, 张剑, 仇惠英, 吴德沛. 异基因造血干细胞移植并发难治性呃逆一例[J/OL]. 中华移植杂志(电子版), 2023, 17(04): 253-255.
[8] 钟文文, 李科, 刘碧好, 蔡炳, 脱颖, 叶雷, 马波, 瞿虎, 汪中扬, 王德娟, 邱剑光. 不同比例聚乳酸/丝素蛋白复合支架在兔尿道缺损修复中的疗效[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(05): 516-522.
[9] 王向丽, 吴涛, 毛东锋, 刘恒, 刘文慧, 周芮, 田红娟. 异基因造血干细胞移植治疗ANKRD26相关性血小板减少症1例并文献复习[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(04): 236-238.
[10] 刘洋, 吴涛, 刘恒, 刘文慧, 田红娟, 周芮, 高铭敏, 王向丽, 张睿. 异基因造血干细胞移植治疗CSF3R基因突变急性髓系白血病M2型1例并文献复习[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(02): 90-92.
[11] 赵敏廷, 张郭, 孙家明. 调节性T细胞与组织修复再生[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(01): 51-55.
[12] 詹卓, 晋佩佩, 张建敏, 何莉. 自体干细胞移植治疗POEMS综合征3例[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(01): 27-29.
[13] 黄佳男, 蒋拓颖, 姚克, 余路阳, 李金英. 羊膜及其来源上皮干细胞在角膜再生医学中的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2023, 13(05): 299-303.
[14] 刘文慧, 吴涛, 张曦. 间充质干细胞联合血小板生成素受体激动剂在异基因造血干细胞移植后血小板恢复中的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2023, 13(04): 242-246.
[15] 何青, 王钰莹, 范振海, 林风琴, 陈辉, 刘燕飞, 刘娟, 何志旭, 余丽梅. 省级重点实验室细胞工程技术平台产学研用开放共享的实践探索[J/OL]. 中华临床实验室管理电子杂志, 2024, 12(01): 1-6.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?