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中华临床医师杂志(电子版) ›› 2021, Vol. 15 ›› Issue (07) : 481 -484. doi: 10.3877/cma.j.issn.1674-0785.2021.07.001

临床研究

高血压患者颈动脉内中膜厚度与心踝血管指数的相关性
黄薇1, 王宏宇1,(), 刘金波1, 刘欢1, 赵红薇1, 赵娜1   
  1. 1. 100144 北京,北京大学首钢医院血管医学中心;100144 北京,北京大学医学部血管健康研究中心
  • 收稿日期:2021-03-22 出版日期:2021-07-15
  • 通信作者: 王宏宇
  • 基金资助:
    北京市卫生局首都卫生发展科研专项(首发2011-4026-02); 北京大学首钢医院院内基金(2010-Y002,2012Y04)

Correlation between carotid intima-media thickness and cardio-ankle vascular index in hypertension subjects

Wei Huang1, Hongyu Wang1,(), Jinbo Liu1, Huan Liu1, Hongwei Zhao1, Na Zhao1   

  1. 1. Department of Vascular Medicine, Peking University Shougang Hospital, Beijing 100144, China; Vascular Health Research Center, Peking University Health Science Center, Beijing 100144, China
  • Received:2021-03-22 Published:2021-07-15
  • Corresponding author: Hongyu Wang
引用本文:

黄薇, 王宏宇, 刘金波, 刘欢, 赵红薇, 赵娜. 高血压患者颈动脉内中膜厚度与心踝血管指数的相关性[J/OL]. 中华临床医师杂志(电子版), 2021, 15(07): 481-484.

Wei Huang, Hongyu Wang, Jinbo Liu, Huan Liu, Hongwei Zhao, Na Zhao. Correlation between carotid intima-media thickness and cardio-ankle vascular index in hypertension subjects[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(07): 481-484.

目的

探讨高血压患者颈动脉内中膜厚度(CIMT)与心踝血管指数(CAVI)之间的相关性。

方法

选择2012年1月至12月在北京大学首钢医院血管医学中心健康体检的324人,根据血压水平分为对照组(173例)及高血压组(151例)。应用超声及动脉僵硬度自动检测装置测定CIMT及CAVI。

结果

高血压组冠心病、卒中发病率显著高于对照组(P<0.05);高血压组患者CIMT、CAVI水平明显高于对照组[(0.62±0.23)mm vs(0.51±0.22)mm;8.40±1.51 vs 7.46±1.10,P均<0.001]。高血压患者CIMT与CAVI呈显著正相关性(r=0.191,P<0.05)。多元线性回归分析提示,年龄、收缩压在高血压患者中与CIMT独立相关(β=0.253,P=0.004;β=0.283,P=0.001)。

结论

高血压患者CIMT显著高于非高血压人群,与CAVI呈正相关性,提示CIMT在预警动脉硬化中发挥重要作用。

Objective

To investigate the correlation between carotid intima-media thickness (CIMT) and cardio-ankle vascular index (CAVI) in hypertension subjects.

Methods

A total of 324 subjects in Department of Vascular Medicine, Peking University Shougang Hospital were enrolled into our study, and they were divided into two groups based on blood pressure levels: control group (173 cases) and hypertension group (151 cases). Two-dimensional ultrasound and VS-1000 were used to measure CIMT and CAVI.

Results

The prevalence of coronary artery disease and stroke was significantly higher in the hypertension group than in the control group (P<0.05). The levels of CIMT and CAVI were significantly higher in the hypertension group than in the control group [(0.62±0.23) mm vs (0.51±0.22) mm and 8.40±1.51 vs 7.46±1.10, respectively, P<0.001 ]. There was a positive correlation between CIMT and CAVI in hypertension subjects (r=0.191, P<0.05). Multivariate analysis showed that age and systolic blood pressure were independent risk factors for CIMT in hypertension subjects (β=0.253, P=0.004; β=0.283, P=0.001).

Conclusion

CIMT is significantly higher and positively correlated with CAVI in hypertension subjects, indicating the role of CIMT in predicting arteriosclerosis.

表1 高血压与非高血压人群基本临床特征比较
项目 对照组(173例) 高血压组(151例) 统计值 P
年龄(岁,
x¯
±s
51.53±13.71 59.00±11.77 t=-6.707 <0.001
男性[例(%)] 66(38.2) 61(40.4) χ2=0.171 0.679
冠心病[例(%)] 2(1.2) 10(6.6) χ2=6.678 0.009
糖尿病[例(%)] 8(4.6) 15(9.9) χ2=3.510 0.063
卒中[例(%)] 0(0) 5(3.3) χ2=6.005 0.005
动脉闭塞症[例(%)] 1(1.2) 3(2.0) χ2=2.243 0.252
吸烟[例(%)] 68(39.3) 51(33.8) χ2=1.062 0.303
体质量指数(kg/m2
x¯
±s
22.17±3.05 23.22±3.73 t=-1.198 0.006
血糖(mmol/L,
x¯
±s
5.34±1.45 5.52±1.15 t=-1.198 0.232
尿酸(µmol/L,
x¯
±s
283.87±77.86 297.50±91.82 t=-1.407 0.160
总胆固醇(mmol/L,
x¯
±s
4.66±1.01 4.93±1.00 t=-2.247 0.025
高密度脂蛋白胆固醇(mmol/L,
x¯
±s
1.48±0.57 1.53±0.49 t=-0.787 0.432
低密度脂蛋白胆固醇(mmol/L,
x¯
±s
2.75±1.23 2.82±0.94 t=-0.530 0.597
三酰甘油(mmol/L,
x¯
±s
1.42±0.97 1.56±1.20 t=-1.101 0.272
糖化血红蛋白(%,
x¯
±s
5.61±0.53 5.77±0.53 t=-0.908 0.370
收缩压(mmHg,
x¯
±s
125.75±13.05 158.87±21.56 t=-16.959 <0.001
舒张压(mmHg,
x¯
±s
80.70±8.72 96.26±12.24 t=-13.006 <0.001
脉压(mmHg,
x¯
±s
45.05±9.55 62.60±16.02 t=-11.758 <0.001
心率(次/min,
x¯
±s
68.29±10.87 72.40±14.41 t=-2.884 0.004
CIMT(mm,
x¯
±s
0.51±0.22 0.62±0.23 t=-4.144 <0.001
CAVI 7.46±1.10 8.40±1.51 t=-6.360 <0.001
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