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中华临床医师杂志(电子版) ›› 2021, Vol. 15 ›› Issue (10) : 726 -730. doi: 10.3877/cma.j.issn.1674-0785.2021.10.002

所属专题: 乳腺疾病

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HER2阳性早期乳腺癌新辅助治疗概述
刘倩1, 向泓雨1, 刘荫华1,()   
  1. 1. 100034 北京,北京大学第一医院乳腺疾病中心
  • 收稿日期:2021-07-12 出版日期:2021-10-15
  • 通信作者: 刘荫华
  • 基金资助:
    北京医学奖励基金会中青年基金项目(2018-0304)

Neoadjuvant therapy for human epidermal growth factor receptor 2 positive early breast cancer

Qian Liu1, Hongyu Xiang1, Yinhua Liu1,()   

  1. 1. Breast Disease Center, Peking University First Hospital, Beijing 100034, China
  • Received:2021-07-12 Published:2021-10-15
  • Corresponding author: Yinhua Liu
引用本文:

刘倩, 向泓雨, 刘荫华. HER2阳性早期乳腺癌新辅助治疗概述[J/OL]. 中华临床医师杂志(电子版), 2021, 15(10): 726-730.

Qian Liu, Hongyu Xiang, Yinhua Liu. Neoadjuvant therapy for human epidermal growth factor receptor 2 positive early breast cancer[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(10): 726-730.

针对具有适应证的人表皮生长因子受体2(HER2)阳性乳腺癌选择新辅助治疗,尤其是选择曲妥珠单抗联合帕妥珠单抗双靶向治疗联合化疗,可以显著提高病理完全缓解(pCR)率。对于经新辅助治疗未获得pCR的患者,术后辅助治疗应该个体化选择。

Neoadjuvant treatment with Pertuzumab, Trastuzumab and chemotherapy resulted in a statistically significant improvement in the total pathologic complete response rate in human epidermal growth factor receptor 2 (HER2) positive early or locally advanced breast cancer. Among patients with HER2-positive early breast cancer who had residual invasive disease after completion of neoadjuvant therapy, the choice of postoperative adjuvant therapy should be individualized.

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