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中华临床医师杂志(电子版) ›› 2023, Vol. 17 ›› Issue (01) : 1 -6. doi: 10.3877/cma.j.issn.1674-0785.2023.01.001

所属专题: 骨科学

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富血小板血浆治疗膝骨关节炎的现状与展望
苗壮1, 刘培来2,()   
  1. 1. 100088 北京,北京航空航天大学仪器科学与光电工程学院 极弱磁场测量技术教育部重点实验室
    2. 250012 济南,山东大学齐鲁医院关节与运动医学科
  • 收稿日期:2022-12-12 出版日期:2023-01-15
  • 通信作者: 刘培来

Platelet rich plasma for treatment of knee osteoarthritis: current status and prospect

Zhuang Miao1, Peilai Liu2,()   

  1. 1. School of Instrumentation and Optoelectronic Engineering, Beihang University, Key Laboratory of Ultra-Weak Magnetic Field Measurement Technology, Ministry of Education, Beijing 100088, China
    2. Department of Joint Surgery and Sport Medicin, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2022-12-12 Published:2023-01-15
  • Corresponding author: Peilai Liu
引用本文:

苗壮, 刘培来. 富血小板血浆治疗膝骨关节炎的现状与展望[J/OL]. 中华临床医师杂志(电子版), 2023, 17(01): 1-6.

Zhuang Miao, Peilai Liu. Platelet rich plasma for treatment of knee osteoarthritis: current status and prospect[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(01): 1-6.

以富血小板血浆为代表的新型生物制剂作为非手术治疗的重要方式,在治疗膝骨关节炎方面取得了特定的效果,受到了极大的关注。但目前富血小板血浆的应用缺乏高证据等级的研究,制备、用法、适应证选择缺乏统一的标准,对关节软骨的作用机制未完全明确,使富血小板血浆的临床应用引发了一定的争论。本文将基于现有研究,从作用机制、适应证选择、制备、最佳使用方式、围术期管理和临床疗效六个方面对富血小板血浆的现状进行阐述,并对其未来发展进行展望。

As an important non-operative treatment, new biological agents represented by platelet rich plasma have achieved specific results in the treatment of knee osteoarthritis and received great attention. However, at present, the application of platelet rich plasma in knee osteoarthritis lacks high level research, the preparation, usage, and indication selection lack unified standards, and the mechanism of action on articular cartilage is not completely clear, which has caused some controversy on the clinical application of platelet rich plasma. Based on the existing research, this article will describe the current situation of platelet rich plasma from six aspects: mechanism of action, indication selection, preparation, optimal use, perioperative management, and clinical efficacy, and discuss its future development.

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