探讨妊娠期高血压疾病患者血清钙离子（Ca²⁺）、25-羟基维生素D（25-（OH）-D）、D-二聚体（D-D）与胎儿生长发育的关系。

选取济宁医学院附属医院于2020年1月至2021年10月接受行剖宫产的妊娠期高血压疾病患者143例为观察组，年龄（29.3±2.7）岁。按病情严重程度分为妊娠期高血压43例，轻度子痫前期44例，重度子痫前期38例，子痫18例。选取同期我院行剖宫产的正常妊娠妇女143例作为对照组，年龄（28.8±2.9）岁。检测所有研究对象的血清Ca²⁺、25-（OH）-D、D-D水平、胎盘重量以及胎儿生长发育情况并作比较。采用Pearson相关性分析血清Ca²⁺、25-（OH）-D、D-D水平与胎儿生产发育的关系。

观察组血清Ca²⁺、25-（OH）-D水平、胎盘重量及胎儿体重、头围、双顶径、腹围、身长低于对照组（均P＜0.05），D-D水平高于对照组（P＜0.05）。随着病情严重程度的增加，患者血清Ca²⁺、25-（OH）-D水平、胎盘重量及胎儿体重、头围、双顶径、腹围、身长呈逐渐下降趋势（均P＜0.05），而D-D水平则呈逐渐升高趋势（P<0.05）。Pearson相关性分析结果显示，D-D与胎盘重量、胎儿的头围、双顶径、腹围、身长、体重呈负相关（r=-0.518、-0.453、-0.501、-0.366、-0.438、-0.492，均P＜0.05），而血清Ca²⁺、25-（OH）-D与胎盘重量、胎儿的头围、双顶径、腹围、身长、体重呈正相关（r=0.408、0.326、0.402、0.411、0.435、0.473；0.487、0.394、0.359、0.376、0.420、0.502，均P＜0.05）。

妊娠期高血压疾病患者的血清Ca²⁺、25-（OH）-D水平降低，D-D水平升高，两者均参与着妊娠期高血压疾病患者病情的发生发展，同时还可影响胎盘生长及胎儿发育。

To explore the relationship of serum calcium (Ca²⁺), 25-hydroxyvitamin D (25-(OH)-D), and D-dimer (D-D) with fetal growth and development in patients with hypertensive disorder complicating pregnancy.

A total of 143 patients with hypertensive disorder complicating pregnancy who received cesarean section at the Affiliated Hospital of Jining Medical University from January 2020 to October 2021 were selected as an observation group. Their mean age was (29.3±2.7) years. According to the severity of the disease, the patients were further divided into a gestational hypertension subgroup (43 cases), a mild preeclampsia subgroup (44 cases), a severe preeclampsia subgroup (38 cases), and an eclampsia subgroup (18 cases). In addition, 143 normal pregnant women who underwent caesarean section at our hospital during the same period were selected as a control group, and their mean age was (28.8±2.9) years. Serum Ca²⁺, 25-(OH)-D, and D-D levels, placental weight, and fetal growth and development were measured and compared in all subjects. Pearson correlation analysis was used to analyze the relationship of serum Ca²⁺, 25-(OH)-D, and D-D levels with fetal production and development.

The levels of serum Ca²⁺ and 25-(OH)-D, placental weight, fetal weight, head circumference, biparietal diameter, abdominal circumference, and body length in the observation group were all lower than those in the control group (P＜0.05 for all), and the level of D-D was higher than that in the control group (P＜0.05). With the increase of the severity of the disease, the levels of serum Ca²⁺ and 25-(OH)-D, placental weight, fetal weight, head circumference, biparietal diameter, abdominal circumference, and body length of the patients decreased gradually (P＜0.05 for all), while the level of D-D increased gradually (P＜0.05). Pearson correlation analysis showed that D-D was negatively correlated with placental weight, fetal head circumference, biparietal diameter, abdominal circumference, body length, and body weight (r=-0.518, -0.453, -0.501, -0.366, -0.438, and -0.492, respectively, P＜0.05 for all), while serum Ca²⁺ and 25-(OH)-D were positively correlated with placental weight, fetal head circumference, biparietal diameter, abdominal circumference, body length, and fetal weight (Ca²⁺: r=0.408, 0.326, 0.402, 0.411, 0.435, and 0.473; 25-(OH)-D: 0.487, 0.394, 0.359, 0.376, 0.420, and 0.502, respectively, P＜0.05 for all).

The levels of serum Ca²⁺ and 25-(OH)-D in patients with hypertensive disorder complicating pregnancy decrease, while the level of D-D increases. All of them are involved in the occurrence and development of hypertensive disorder complicating pregnancy, and can also affect the growth of placenta and fetal development.