探讨自然周期冻融胚胎移植术对辅助生殖技术下妊娠结局的影响。

选择于2020年3月至2021年3月在亳州市人民医院行体外受精冻融胚胎移植的单胎活产患者199例作为研究对象，年龄（30.7±3.4）岁（20~41岁）。按照内膜准备方案分为自然周期组93例与激素替代周期组106例。自然周期组采用自然周期冻融胚胎移植术，激素替代周期组采用激素替代周期冻融胚胎移植术。比较两组临床资料，新生儿结局及围产期结局情况。

自然周期组与激素替代周期组年龄、不孕年限、基础卵泡雌激素、基础促黄体生成素、抗缪勒氏管激素、获卵数、超促排周期的促性腺激素总量、正常受精卵数及移植胚胎数比较差异均无统计学意义（均P＞0.05）。自然周期组中正常体重儿（88.17%）高于激素替代周期组（66.98%），差异有统计学意义（P=0.017）。自然周期组与激素替代周期组巨大儿、低体重儿、早产儿和新生儿出生体重比较差异均无统计学意义（均P＞0.05）。自然周期组与激素替代周期组妊娠期糖尿病、妊娠期高血压、羊水过多、羊水过少、胎盘粘连、胎盘前置、胎膜早破和产后出血发生率比较差异亦均无统计学意义（分别为11.83%比16.98%、7.53%比9.43%、3.23%比6.60%、2.15%比6.60%、3.23%比4.72%、9.43%比14.15%、12.90%比16.04%，21.51%比24.53%，均P＞0.05）。

自然周期冻融胚胎移植术对辅助生殖激素下妊娠结局良好，值得临床借鉴。

To explore the effect of natural cycle freeze-thaw embryo transfer on pregnancy outcome in assisted reproductive technology.

A total of 199 cases of patients with singleton live birth delivery who underwent in vitro fertilization and freeze-thaw embryo transfer at Bozhou People's Hospital from March 2020 to March 2021 were selected as the research subjects. The mean age of the patients was (30.7±3.4) years (range, 20-41 years). According to the endometrial preparation plan, the patients were divided into either a natural cycle group (93 cases) or a hormone replacement cycle group (106 cases). The natural cycle group used natural cycle freeze-thaw embryo transfer, and the hormone replacement cycle group used hormone replacement cycle freeze-thaw embryo transfer. The clinical data, neonatal outcome, and perinatal outcome were compared between the two groups.

The age, infertility years, basal follicular estrogen, basal luteinizing hormone, anti-Muller test tube hormone, number of eggs obtained, total gonadotropin in the super-stimulation cycle, normal fertilization number of eggs, and number of embryos transferred in the two groups were comparable with no significant difference (P＞0.05 for all). The rate of infants with normal body weight was significantly higher in the natural cycle group (88.17%) than in the hormone replacement cycle group (66.98%; P=0.017). There was no significant differences in birth weight of macrosomia, low body mass infants, preterm infants, or body weight of neonates between the two groups (P＞0.05 for all). And there was no significant differences in the rates of gestational diabetes mellitus, gestational hypertension, hyperamniotic fluid, hypoamniotic fluid, placental adhesion, placental previa, premature rupture of membranes, or postpartum hemorrhage between the natural cycle group and the hormone replacement cycle group (11.83% vs 16.98%, 7.53% vs 9.43%, 3.23% vs 6.60%, 2.15% vs 6.60%, 3.23% vs 4.72%, 9.43% vs 14.15%, 12.90% vs 16.04%, and 21.51% vs 24.53%, respectively, P＞0.05 for all).

The natural cycle freeze-thaw embryo transfer has a good outcome for pregnancy under assisted reproductive hormones.