中华临床医师杂志(电子版) ›› 2023, Vol. 17 ›› Issue (01) : 84 -88. doi: 10.3877/cma.j.issn.1674-0785.2023.01.015 × 扫一扫
医院管理
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通信作者:
Dehai Wang1, Tianjun Li1, Lei Yu1, Changlong Guo1, Mingxia Fang1, Huafang Gao1, Jianen Gao1, Xu Ma1,†()
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汪德海, 李天君, 于磊, 郭昌龙, 方明霞, 高华方, 高建恩, 马旭. 肿瘤患者生殖储备协作网络系统设计与建设[J]. 中华临床医师杂志(电子版), 2023, 17(01): 84-88.
Dehai Wang, Tianjun Li, Lei Yu, Changlong Guo, Mingxia Fang, Huafang Gao, Jianen Gao, Xu Ma. Design and construction of national reproductive reserve network for cancer patients[J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(01): 84-88.
利用现代信息技术建设肿瘤患者生殖储备协作网络系统（NRRN-CP），服务于肿瘤患者的生育力保存，尤其是性腺组织的保存与应用，提供规范化的组织存储体系及信息管理系统，为肿瘤患者性腺组织的保存与应用提供质量与安全的保障。
以满足不断变化的需求为出发点，采用迭代和分步的方式建设系统。根据业务流程与数据库、信息交换与共享、数据安全保护、子系统功能、数据管理与分析等应用需求，设计了平台框架，研究与建设肿瘤患者生殖储备协作网络系统。
NRRN-CP采用多边形软件架构以满足不同用户对系统的业务要求；使用表征状态转移（RESTful）数据交换方式降低软件描述复杂程度；使用超文本安全传输协议（HTTPS）的数据传输方式确保数据传输的安全性。系统规范了97个关键字段，其中文本型字段46个，数字型字段51个，信息内容包括患者基本信息、体检、临床诊断、性腺采集与存储、性腺移植及移植后随访等全生命周期的信息资料，实现了对需要进行生育力保护的肿瘤患者的信息及样本进行收集、整理和存储，到最终使用的全过程进行闭环管理。
NRRN-CP是临床开展肿瘤患者生育力保护的基础之一，可对所存储的性腺组织样本进行有效的管理，在样本存储过程、样本使用、样本移植后的随访及样本环境的监测等方面进行了规范与记录，确保样本长期存储的安全性。
To construct a cooperative network for reproductive preservation of gonadal tissue from cancer patients by using informatics technologies, so as to provide quality and safety guarantee for the preservation and application of gonadal tissue from cancer patients.
To meet the changing demand of the business process, the system was built in an iterative and step-by-step manner. A platform framework was designed to develop a collaborative network system of reproductive preservation for cancer patients according to the application requirements of business process and database, information exchange and sharing, data security protection, subsystem function, and data management and analysis.
Polygonal software architecture was used to meet the business requirements of different users. Representational state transition (RESTful) method was employed for data exchange to reduce software description complexity. Hypertext secure transfer protocol (HTTPS) was used for data transmission to ensure the security of data transmission. The system had standardized 97 key fields, including 46 text fields and 51 digital fields. The information content included patients' basic information, physical examination, clinical diagnosis, gonad tissue collection and storage, transplantation and post-transplantation follow-up, and other life-cycle information. By using this system, a closed-loop management of the gondal samples and related information from cancer patients who need fertility protection was achieved.
As one of the bases for the reproductive preservation of cancer patients, this network provides an effective tool for the management of cancer patients' gonad tissues bio-banking procedure, such as sample storage procedure, patient follow-up after transplantation, and environment monitoring and recording. It provides a system to ensure the quality and safety for long-term tissue storage.