切换至 "中华医学电子期刊资源库"
高级检索
中华临床医师杂志(电子版)

中华临床医师杂志(电子版) ›› 2023, Vol. 17 ›› Issue (01) : 89 -92. doi: 10.3877/cma.j.issn.1674-0785.2023.01.016

综述

川崎病病原菌感染及易感基因多态性的研究现状
孙飞1, 罗军2,†(), 向金波2, 胡小燕2   
  1. 1. 443002　宜昌，湖北省宜昌市三峡大学第二临床医学院儿科
    2. 443001　宜昌，湖北省宜昌市三峡大学第二临床医学院儿科
  • 收稿日期:2022-01-17 出版日期:2023-01-15
  • 通信作者: 罗军

Current status of research of pathogen infection and susceptibility-related gene polymorphisms in Kawasaki disease

Fei Sun1, Jun Luo2,†(), Jinbo Xiang2, Xiaoyan Hu2   

  1. 1. Department of Pediatrics, School of Medicine, Three Gorges University, Yichang 443002, China
    2. General Archives Department of Linfen People's Hospital, Linfen 041000, China
  • Received:2022-01-17 Published:2023-01-15
  • Corresponding author: Jun Luo
全文 ( ) 下载PDF ( ) 导出引用
引用本文：

孙飞, 罗军, 向金波, 胡小燕. 川崎病病原菌感染及易感基因多态性的研究现状[J]. 中华临床医师杂志(电子版), 2023, 17(01): 89-92.

Fei Sun, Jun Luo, Jinbo Xiang, Xiaoyan Hu. Current status of research of pathogen infection and susceptibility-related gene polymorphisms in Kawasaki disease[J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(01): 89-92.

川崎病多发于低龄儿童，以全身性心血管炎性表现为主。川崎病自20世纪60年代被发现后，其病因至今仍未明确，目前已成为导致儿童获得性心脏病的主要原因。从目前的现有研究来看，川崎病的发生具有种族、地域、遗传、基因易感等特点。冠状动脉损伤是川崎病的严重并发症之一，导致其发生与基因的多态性有密切的关系。近年来，川崎病的发病率呈现不断升高趋势，其发生的原因与细菌、病毒、肺炎支原体等病原体感染引发的免疫反应以及易感基因多态性相关。本文拟对近年来川崎病病原菌感染与基因多态性的研究现状进行阐述，以期为该病患者的治疗及该病的后续研究提供相应理论支持。

关键词: 川崎病, 病原菌感染, 相关基因多态性, 研究现状

Kawasaki disease is more common in younger children, mainly having systemic cardiovascular inflammatory manifestations. The etiology of Kawasaki disease remains unknown since its discovery in the 1960s and it has become the major cause of acquired heart disease in children. According to current research, the occurrence of Kawasaki disease is characterized by ethnic, regional, genetic, and genetic susceptibility. Coronary artery injury is one of the serious complications of Kawasaki disease, closely linking its occurrence to genetic polymorphisms. In recent years, the incidence of Kawasaki disease has shown an increasing trend, and the cause of which is associated with the immune response caused by infection of bacteria, viruses, Mycoplasma pneumonia, chlamydia, and other pathogens, and susceptibility-related gene polymorphisms. This paper intends to explain the research status of pathogen infection and gene polymorphisms in Kawasaki disease in recent years, in order to provide corresponding theoretical support for the treatment of patients with the disease and the follow-up study of the disease.

Key words: Kawasaki disease, Pathogen infection, Related gene polymorphism, Research status
1
Kawasaki T. Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children [J]. Arerugi, 1967, 16(3): 178-222.
2
胡景伟, 周忠蜀. 川崎病冠状动脉损害的临床特点及随访研究 [J/CD].中华临床医师杂志（电子版）, 2016, 10(9): 1204-1207.
3
余艳萍, 阿布来提·阿不都哈尔. 川崎病诊断与治疗新进展 [J/CD].中华临床医师杂志（电子版）, 2016, 10(4): 566-570.
4
Cunha BA, Pherez FM, Alexiadis V, et al. Adult Kawasaki's disease with myocarditis, splenomegaly, and highly elevated serum ferritin levels [J]. Heart Lung, 2010, 39(2): 164-172.
5
杨艳章, 王莉, 杨艳芳, 等. 川崎病患儿并发冠状动脉病变相关危险因素与治疗分析 [J].中国妇幼保健, 2019, 34(14): 3244-3246.
6
Matsubara K, Fukaya T. The role of superantigens of group A Streptococcus and Staphylococcus aureus in Kawasaki disease [J]. Curr Opin Infect Dis, 2007, 20(3): 298-303.
7
Akiyama T, Yashiro K. Probable role of Streptococcus pyogenes in Kawasaki disease [J]. Eur J Pediatr, 1993, 152(2): 82-92.
8
Blacklow NR, Kapikian AZ. Serological studies with EB virus in infectious lymphocytosis [J]. Nature, 1970, 226(5246): 647.
9
彭俊娟, 王锦, 朱伟, 等. 儿童病毒感染与川崎病发病及冠状动脉病变的相关性 [J]. 中国妇幼健康研究, 2016, 27(6): 760-762.
10
李雪茹, 解启莲, 张晨宇, 等. 川崎病患儿外周血淋巴细胞亚群变化及其临床意义 [J].现代医学, 2019, 47(1): 9-12.
11
Garrido-Barbero M, Arnaez J, Garcia-Alix A. Controversies in the therapeutic approach to congenital cytomegalovirus infection [J]. Infection, 2020, 48(3): 463-469.
12
骆淑英, 刘营, 傅涛, 等. 登革热暴发9年后感染者抗体阳性率调查 [J].中国媒介生物学及控制杂志, 2019, 30(4): 371-373.
13
李金玲, 骆盼, 司朝辉. 支原体感染对川崎病患儿血清炎症因子水平及冠状动脉损害的影响 [J]. 川北医学院学报, 2020, 35(1): 69-72.
14
蒋秀芳, 任常军, 朱舒, 等. 川崎病患儿肺炎支原体感染的临床指征及特点 [J].中国病原生物学杂志, 2019, 14(1): 96-98.
15
Hara T, Yamamura K, Sakai Y. The up-to-date pathophysiology of Kawasaki disease [J]. Clin Transl Immunology, 2021, 10(5): e1284.
16
Sharma C, Ganigara M, Galeotti C, et al. Multisystem inflammatory syndrome in children and Kawasaki disease: a critical comparison [J]. Nat Rev Rheumatol, 2021, 17(12): 731-748.
17
Lee NH, Choi HJ, Kim YH. Clinical usefulness of serum procalcitonin level in distinguishing between Kawasaki disease and other infections in febrile children [J]. Korean J Pediatr, 2017, 60(4): 112-117.
18
张超英, 李晓惠, 林瑶, 等. 血小板反应蛋白在川崎病中的变化及意义 [J/CD].中华临床医师杂志（电子版）, 2013, 7(10): 4528-4530.
19
Tremoulet AH. Adjunctive therapies in Kawasaki disease [J]. Int J Rheum Dis, 2018, 21(1): 76-79.
20
Rowley AH, Shulman ST. Pathogenesis and management of Kawasaki disease [J]. Expert Rev Anti Infect Ther, 2010, 8(2): 197-203.
21
Liu D, Song M, Jing F, et al. Diagnostic value of immune-related genes in Kawasaki disease [J]. Front Genet, 2021, 12: 763496.
22
Takahashi K, Oharaseki T, Yokouchi Y. Histopathological aspects of cardiovascular lesions in Kawasaki disease [J]. Int J Rheum Dis, 2018, 21(1): 31-35.
23
Takahashi K, Oharaseki T, Yokouchi Y. Histopathological aspects of cardiovascular lesions in Kawasaki disease[J]. Int J Rheum Dis, 2018, 21(1): 31-35.
24
Ye Q, Gong FQ, Shang SQ, et al. Intravenous immunoglobulin treatment responsiveness depends on the degree of CD8+ T cell activation in Kawasaki disease [J]. Clin Immunol, 2016, 171: 25-31.
25
Mutter J, Yeter D. Kawasaki's disease, acrodynia, and mercury [J]. Curr Med Chem, 2008, 15(28): 3000-3010.
26
郑小兰, 张怡. 川崎病内皮细胞模型及其发病机制研究进展 [J].医学研究杂志, 2019, 48(06): 11-13.
27
张园海, 何跃娥, 项如莲,等. 川崎病急性期血清对血管内皮细胞MMP-3和TNF-α表达的影响及丙种球蛋白的干预作用 [J]. 浙江医学, 2009, 31(4): 451-453.
28
丛晓辉, 塔依尔·斯拉吉, 祖丽皮娅·黑力木, 等. 基质金属蛋白酶-9、抗内皮细胞抗体和抗中性粒细胞胞浆抗体在川崎病冠状动脉损害中的作用及临床意义 [J].中国妇幼保健, 2019, 34(10): 2284-2286.
29
姜宇芬, 卢宏柱. 川崎病与自身免疫-炎症-凝血轴 [J].长江大学学报（自然科学版）, 2019, 16(9): 89-93.
30
Cortegano I, Rodríguez M, Martín I, et al. Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses [J]. Cell Death Dis, 2017, 8(8): e3000.
31
邵东, 陈洁. 川崎病患儿血清中25-(OH)D3、NT-proBNP 和IL-6表达水平及诊断价值 [J].中国地方病防治杂志, 2019, 34(06): 690-691.
32
Nagasawa M, Ashiarai M, Oba R, et al. Circulating CD3+HLA-DR+ extracellular vesicles are not increased in the acute phase of kawasaki disease [J]. SN Compr Clin Med, 2020, 2(2): 511-513.
33
Gholami M, Amoli MM, Sharifi F. Comments on and assessment of "The rs498872 polymorphism is associated with an elevated susceptibility to glioma: a meta-analysis of 36,264 subjects" [J]. Acta Neurol Belg, 2020, 120(5): 1201-1202.
34
Shimizu C, Kim J, Eleftherohorinou H, et al. HLA-C variants associated with amino acid substitutions in the peptide binding groove influence susceptibility to Kawasaki disease [J]. Hum Immunol, 2019,80(9): 731-738.
35
段炤, 林智平, 刘青, 等. CD4~+CD_(25)~+调节性T淋巴细胞与辅助性T淋巴细胞17在川崎病发病机制中的作用 [J].中华实用儿科临床杂志, 2017, 32(9): 652-655.
36
程首超, 程衍杨, 吴金龙. CD40基因多态性与川崎病及其冠状动脉损伤的相关性研究 [J].中国当代儿科杂志, 2014, 16(10): 1025-1028.
37
蒋勇, 李敬风. FCGR2A基因rs1801274位点基因多态性与川崎病相关性研究的Meta分析 [J]. 现代医学, 2017, 45(4): 465-471.
38
张媛, 张白杜, 刘云锋, 等. ABCC4、FCGR2A及BLK基因多态性与华南地区儿童川崎病遗传易感相关性研究 [J].中华检验医学杂志, 2017, 40(5): 372-377.
39
Li X, Zhang F, Zhou H, et al. Interplay of TNF-α, soluble TNF receptors and oxidative stress in coronary chronic total occlusion of the oldest patients with coronary heart disease [J]. Cytokine, 2020, 125: 154836.
40
梅洁花, 王勤, 温鹏强, 等. 急性期川崎病IL-17基因组蛋白甲基化修饰改变及意义 [J]. 中华微生物学和免疫学杂志, 2016, 36(9): 692-698.
41
董启忠, 张超, 李月茹. BLK基因多态性与川崎病及其临床特点的相关性 [J].临床儿科杂志, 2015, 33(4): 342-344.
42
Kim D, Kim W, Joo SK, et al. Association between body size-metabolic phenotype and nonalcoholic steatohepatitis and significant fibrosis [J]. J Gastroenterol, 2020, 55(3): 330-341.
43
Fatar M. Air pollution and stroke: is there really a significant relationship [J]. Cerebrovasc Dis, 2019, 47(1-2): 101.
[1] 童文静, 陈晓华, 黄建芳, 杨翠, 杜云芳. 川崎病患儿颈动脉内膜-中层厚度、踝肱指数分析及其与冠状动脉病变程度的相关性[J]. 中华医学超声杂志（电子版）, 2021, 18(02): 207-211.
[2] 包敏, 刘波, 曹爱梅, 郑彤, 任军, 郑春华. 高频探头在儿童冠状动脉检查中的应用[J]. 中华医学超声杂志（电子版）, 2016, 13(11): 826-830.
[3] 罗秋红, 周开宇. 川崎病休克综合征的临床研究进展[J]. 中华妇幼临床医学杂志(电子版), 2016, 12(04): 471-474.
[4] 余莉, 王一斌, 乔莉娜, 华益民, 朱琦, 石晓青, 周开宇, 刘瀚旻. 川崎病并发冠状动脉损伤的危险因素分析[J]. 中华妇幼临床医学杂志(电子版), 2015, 11(02): 240-243.
[5] 王小永. 不典型川崎病86例临床分析[J]. 中华妇幼临床医学杂志(电子版), 2012, 08(04): 442-443.
[6] 苏海浩, 王波. 小儿川崎病36例临床治疗分析[J]. 中华妇幼临床医学杂志(电子版), 2012, 08(04): 439-441.
[7] 陈幼芬, 吴清轩. 脑钠肽与川崎病关系的研究进展[J]. 中华妇幼临床医学杂志(电子版), 2012, 08(02): 224-227.
[8] 王小川, 蔡雯雯, 贾苍松. 261例川崎病合并感染的临床分析[J]. 中华妇幼临床医学杂志(电子版), 2012, 08(01): 32-35.
[9] 刘瀚旻, 高举, 王晓琴. 糖皮质激素在川崎病治疗中作用的循证医学研究[J]. 中华妇幼临床医学杂志(电子版), 2005, 01(02): 87-92.
[10] 张玉凤, 徐鹏飞, 唐甜甜, 刘瑞清, 万涵. 儿童川崎病并发胆汁淤积和无菌性脑膜炎一例[J]. 中华实验和临床感染病杂志(电子版), 2023, 17(01): 60-64.
[11] 赵扬, 王彩英, 万钢, 张新鑫, 何树新, 郝一炜, 庞琳. 儿童甲型流感合并川崎病的临床特征[J]. 中华实验和临床感染病杂志(电子版), 2020, 14(03): 258-263.
[12] 赵立连, 卢明峰, 魏锦强, 何利雷, 许挺, 邢基斯, 王昌兵. 基于WOS数据库巨大肩袖撕裂全球研究现状与热点分析[J]. 中华肩肘外科电子杂志, 2021, 09(02): 119-130.
[13] 张娟, 纪青, 胡国宏, 谭成, 王双双, 易秀英. CD11b基因rs4597342位点多态性与川崎病的相关性研究[J]. 中华诊断学电子杂志, 2023, 11(02): 92-96.
[14] 寿碧江, 李东芳. 自发性脑出血预后量表的研究现状[J]. 中华脑血管病杂志(电子版), 2020, 14(03): 167-171.
阅读次数
全文


摘要

版权所有 中华医学会 中华医学电子音像出版社有限责任公司  京ICP备14006079号-1  网络出版服务许可证：(署)网出证(京)字第075号