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中华临床医师杂志(电子版) ›› 2023, Vol. 17 ›› Issue (03) : 356 -359. doi: 10.3877/cma.j.issn.1674-0785.2023.03.021

综述

肌肉减少症与肝癌研究进展
马金栋, 焦向飞, 蔡婷婷, 陈强谱()   
  1. 256600 山东滨州,滨州医学院附属医院肝胆外科
    256600 山东滨州,滨州医学院附属医院临床营养科
  • 收稿日期:2021-12-21 出版日期:2023-03-15
  • 通信作者: 陈强谱
  • 基金资助:
    山东省省级临床重点专科建设基金资助项目(SLCZDZK-0701); 山东省省级临床重点专科建设基金资助项目(SLCZDZK-2401)

Research progress of sarcopenia and liver cancer

Jingdong Ma, Xiangfei Jiao, Tingting Cai, Qiangpu Chen()   

  1. The Second Surgery Department of the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
    Department of clinical nutrition, Affiliated Hospital of Binzhou Medical College, Binzhou 256600, China
  • Received:2021-12-21 Published:2023-03-15
  • Corresponding author: Qiangpu Chen
引用本文:

马金栋, 焦向飞, 蔡婷婷, 陈强谱. 肌肉减少症与肝癌研究进展[J/OL]. 中华临床医师杂志(电子版), 2023, 17(03): 356-359.

Jingdong Ma, Xiangfei Jiao, Tingting Cai, Qiangpu Chen. Research progress of sarcopenia and liver cancer[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(03): 356-359.

肌肉减少症是一种进行性的全身骨骼肌质量下降和功能减退的临床综合征,与多种疾病的不良临床结局相关。临床中有11%~45%的肝癌患者存在肌肉减少症。肝癌关肌肉减少症的原因是多种因素共同作用的结果,目前发病机制尚不清楚。肌肉减少症对肝癌治疗的临床结局和预后都有明显的影响。通过从营养、运动、药物等方面治疗肝癌相关肌肉减少症,可改善肝癌患者的临床结局和预后。

Sarcopenia is a syndrome associated with low muscle mass and muscle strength, and it is related to adverse outcomes in a variety of diseases. Sarcopenia occurs in 11% to 45% of liver cancer patients.The cause of liver cancer associated sarcopenia is the result of many factors, and the pathogenesis is still unclear. Sarcopenia has significant influence on the clinical outcome and prognosis of liver cancer. Thus, the clinical outcome and prognosis of patients with liver cancer can be improved by the intervention of sarcopenia from the aspects of nutrition, exercise, and medicine.

1
卢艳敏, 陈强谱. 肌肉减少症的诊断及治疗 [J/OL]. 中华临床医师杂志(电子版), 2014(24): 4454-4457.
2
蔡婷婷, 王蕾, 陈强谱. 肌肉减少症对老年患者术后并发症的影响及干预措施 [J]. 中华老年医学杂志, 2021, 40(8): 971-975.
3
Takada H, Kurosaki M, Nakanishi H, et al. Impact of pre-sarcopenia in sorafenib treatment for advanced hepatocellular carcinoma [J]. PLoS One, 2018, 13(6): e198812.
4
郑荣寿, 孙可欣, 张思维, 等. 2015年中国恶性肿瘤流行情况分析 [J]. 中华肿瘤杂志, 2019, 41(1): 19-28.
5
郑艺. 运动干预支持在老年肌肉减少症病人中应用的研究进展 [J]. 全科护理, 2020, 18(30): 4100-4103.
6
戚倩, 吴蓓雯, 费晓燕. 肿瘤相关性肌肉减少症影响因素的研究进展 [J]. 中国全科医学, 2018, 21(15): 1769-1774.
7
程群, 郑丽丽, 章振林. 肌肉减少症流行病学及发病机制 [J]. 中华骨质疏松和骨矿盐疾病杂志, 2016, 9(3): 228-235.
8
Pamoukdjian F, Bouillet T, Levy V, et al. Prevalence and predictive value of pre-therapeutic sarcopenia in cancer patients: A systematic review [J]. Clin Nutr, 2018, 37(4): 1101-1113.
9
Ruiz-Margain A, Roman-Calleja B M, Moreno-Guillen P, et al. Nutritional therapy for hepatocellular carcinoma [J]. World J Gastrointest Oncol, 2021, 13(10): 1440-1452.
10
向谦, 陈丽, 付丹, 等. 肌肉减少症对接受TACE治疗原发性肝癌患者生存期的影响 [J]. 现代消化及介入诊疗, 2021, 26(2): 202-207.
11
Takada H, Kurosaki M, Nakanishi H, et al. Impact of pre-sarcopenia in sorafenib treatment for advanced hepatocellular carcinoma [J]. PLoS One, 2018, 13(6): e198812.
12
Damanti S, Azzolino D, Roncaglione C, et al. Efficacy of nutritional interventions as stand-alone or synergistic treatments with exercise for the management of sarcopenia [J]. Nutrients, 2019, 11(9): 1991.
13
杨玲, 杜娟, 刘荣雁, 等. 肌肉减少症病因学研究现状与展望 [J]. 中国骨质疏松杂志, 2020, 26(11): 1689-1693.
14
Hamrick M W, McGee-Lawrence M E, Frechette D M. Fatty infiltration of skeletal muscle: mechanisms and comparisons with bone marrow adiposity [J]. Front Endocrinol (Lausanne), 2016, 7: 69.
15
Fujiwara N, Nakagawa H, Kudo Y, et al. Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma [J]. J Hepatol, 2015, 63(1): 131-140.
16
Buckinx F, Landi F, Cesari M, et al. Pitfalls in the measurement of muscle mass: a need for a reference standard [J]. J Cachexia Sarcopenia Muscle, 2018, 9(2): 269-278.
17
Hamaguchi Y, Kaido T, Okumura S, et al. Preoperative intramuscular adipose tissue content is a novel prognostic predictor after hepatectomy for hepatocellular carcinoma [J]. J Hepatobiliary Pancreat Sci, 2015, 22(6): 475-485.
18
王青青, 苏晓雨, 彭玉晓, 等. 基于CT的骨骼肌参数诊断肿瘤病人肌肉减少症[J]. 国际医学放射学杂志, 2021, 44(3): 324-329.
19
Wu C H, Liang P C, Hsu C H, et al. Total skeletal, psoas and rectus abdominis muscle mass as prognostic factors for patients with advanced hepatocellular carcinoma [J]. J Formos Med Assoc, 2021, 120(1 Pt 2): 559-566.
20
Chang K V, Chen J D, Wu W T, et al. Association between loss of skeletal muscle mass and mortality and tumor recurrence in hepatocellular carcinoma: a systematic review and meta-analysis [J]. Liver Cancer, 2018, 7(1): 90-103.
21
Marasco G, Serenari M, Renzulli M, et al. Clinical impact of sarcopenia assessment in patients with hepatocellular carcinoma undergoing treatments [J]. J Gastroenterol, 2020, 55(10): 927-943.
22
Berardi G, Antonelli G, Colasanti M, et al. Association of sarcopenia and body composition with short-term outcomes after liver resection for malignant tumors [J]. JAMA Surg, 2020, 155(11): e203336.
23
Voron T, Tselikas L, Pietrasz D, et al. Sarcopenia impacts on short- and long-term results of hepatectomy for hepatocellular carcinoma [J]. Ann Surg, 2015, 261(6): 1173-1183.
24
Hiraoka A, Otsuka Y, Kawasaki H, et al. Impact of muscle volume and muscle function decline in patients undergoing surgical resection for hepatocellular carcinoma [J]. J Gastroenterol Hepatol, 2018, 33(6): 1271-1276.
25
王蕾, 卢艳敏, 冀海斌, 等. 肌肉减少症对肝切除术后患者预后影响的Meta分析 [J]. 现代肿瘤医学, 2021, 29(20): 3600-3604.
26
Bajric T, Kornprat P, Faschinger F, et al. Sarcopenia and primary tumor location influence patients outcome after liver resection for colorectal liver metastases [J]. Eur J Surg Oncol, 2021: S0748-7983(21)00736-8.
27
Heil J, Heid F, Bechstein W O, et al. Sarcopenia predicts reduced liver growth and reduced resectability in patients undergoing portal vein embolization before liver resection - A DRAGON collaborative analysis of 306 patients [J]. HPB (Oxford), 2021: S1365-182X(21)01458-1.
28
Denbo J W, Kim B J, Vauthey J N, et al. Overall body composition and sarcopenia are associated with poor liver hypertrophy following portal vein embolization [J]. J Gastrointest Surg, 2021, 25(2): 405-410.
29
Runkel M, Diallo T D, Lang S A, et al. The role of visceral obesity, sarcopenia and sarcopenic obesity on surgical outcomes after liver resections for colorectal metastases [J]. World J Surg, 2021, 45(7): 2218-2226.
30
Hamaguchi Y, Kaido T, Okumura S, et al. Proposal for new selection criteria considering pre-transplant muscularity and visceral adiposity in living donor liver transplantation [J]. J Cachexia Sarcopenia Muscle, 2018, 9(2): 246-254.
31
Kaido T, Tamai Y, Hamaguchi Y, et al. Effects of pretransplant sarcopenia and sequential changes in sarcopenic parameters after living donor liver transplantation [J]. Nutrition, 2017,33:195-198.
32
Kim Y R, Park S, Han S, et al. Sarcopenia as a predictor of post-transplant tumor recurrence after living donor liver transplantation for hepatocellular carcinoma beyond the Milan criteria [J]. Sci Rep, 2018,8(1):7157.
33
Lanza E, Masetti C, Messana G, et al. Sarcopenia as a predictor of survival in patients undergoing bland transarterial embolization for unresectable hepatocellular carcinoma [J]. PLoS One, 2020, 15(6): e232371.
34
Fujita M, Takahashi A, Hayashi M, et al. Skeletal muscle volume loss during transarterial chemoembolization predicts poor prognosis in patients with hepatocellular carcinoma [J]. Hepatol Res, 2019, 49(7): 778-786.
35
Kobayashi T, Kawai H, Nakano O, et al. Rapidly declining skeletal muscle mass predicts poor prognosis of hepatocellular carcinoma treated with transcatheter intra-arterial therapies [J]. BMC Cancer, 2018, 18(1): 756.
36
Lee J, Cho Y, Park S, et al. Skeletal muscle depletion predicts the prognosis of patients with hepatocellular carcinoma treated with radiotherapy [J]. Front Oncol, 2019, 9: 1075.
37
Faron A, Sprinkart A M, Pieper C C, et al. Yttrium-90 radioembolization for hepatocellular carcinoma: Outcome prediction with MRI derived fat-free muscle area [J]. Eur J Radiol, 2020, 125: 108889.
38
Kim N, Yu J I, Park H C, et al. Incorporating sarcopenia and inflammation with radiation therapy in patients with hepatocellular carcinoma treated with nivolumab [J]. Cancer Immunol Immunother, 2021, 70(6): 1593-1603.
39
Nishikawa H, Nishijima N, Enomoto H, et al. Prognostic significance of sarcopenia in patients with hepatocellular carcinoma undergoing sorafenib therapy [J]. Oncol Lett, 2017, 14(2): 1637-1647.
40
Qayyum A, Bhosale P, Aslam R, et al. Effect of sarcopenia on systemic targeted therapy response in patients with advanced hepatocellular carcinoma [J]. Abdom Radiol (NY), 2021, 46(3): 1008-1015.
41
Bibby N, Griffin O. Nutritional considerations for the management of the older person with hepato-pancreatico-biliary malignanc y [J]. Eur J Surg Oncol, 2021, 47(3 Pt A): 533-538.
42
Nakahara S, Takasaki M, Abe S, et al. Aggressive nutrition therapy in malnutrition and sarcopenia [J]. Nutrition, 2021, 84: 111109.
43
Cogo E, Elsayed M, Liang V, et al. Are supplemental branched-chain amino acids beneficial during the oncological peri-operative period: a systematic review and meta-analysis [J]. Integr Cancer Ther, 2021, 20: 1873215983.
44
Cavallucci V, Pani G. The leucine catabolite and dietary supplement beta-hydroxy-beta-methyl butyrate (HMB) as an epigenetic regulator in muscle progenitor cells [J]. Metabolites, 2021, 11(8).
45
Aubertin-Leheudre M, Buckinx F. Effects of citrulline alone or combined with exercise on muscle mass, muscle strength, and physical performance among older adults: a systematic review [J]. Curr Opin Clin Nutr Metab Care, 2020, 23(1): 8-16.
46
Koya S, Kawaguchi T, Hashida R, et al. Effects of in-hospital exercise on liver function, physical ability, and muscle mass during treatment of hepatoma in patients with chronic liver disease [J]. Hepatol Res, 2017, 47(3): E22-E34.
47
Koya S, Kawaguchi T, Hashida R, et al. Effects of in-hospital exercise on sarcopenia in hepatoma patients who underwent transcatheter arterial chemoembolization [J]. J Gastroenterol Hepatol, 2019, 34(3): 580-588.
48
Davis M P, Panikkar R. Sarcopenia associated with chemotherapy and targeted agents for cancer therapy [J]. Ann Palliat Med, 2019, 8(1): 86-101.
49
Gkekas N K, Anagnostis P, Paraschou V, et al. The effect of vitamin D plus protein supplementation on sarcopenia: A systematic review and meta-analysis of randomized controlled trials [J]. Maturitas, 2021, 145: 56-63.
50
Ebner N, Anker S D, von Haehling S. Recent developments in the field of cachexia, sarcopenia, and muscle wasting: highlights from the 12th Cachexia Conference [J]. J Cachexia Sarcopenia Muscle, 2020, 11(1): 274-285.
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