切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2023, Vol. 17 ›› Issue (05) : 591 -595. doi: 10.3877/cma.j.issn.1674-0785.2023.05.016

综述

MUC16/CA125在良恶性肿瘤诊治中的作用及其研究进展
吴一菡, 雷章, 卢宏达()   
  1. 430014 湖北武汉,华中科技大学同济医学院附属武汉中心医院肿瘤科;430014 湖北武汉,武汉市肿瘤研究所;430014 湖北武汉,华中科技大学同济医学院附属武汉中心医院分子诊断湖北省重点实验室
  • 收稿日期:2022-03-14 出版日期:2023-05-15
  • 通信作者: 卢宏达

Progress in understanding of role of MUC16/CA125 in diagnosis and treatment of benign and malignant tumors

Yihan Wu, Zhang Lei, Hongda Lu()   

  1. Department of Oncology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China; The Cancer Research Institute of Wuhan, Wuhan 430014, China; Key Laboratory for Molecular Diagnosis of Hubei Province, Wuhan 430014, China
  • Received:2022-03-14 Published:2023-05-15
  • Corresponding author: Hongda Lu
引用本文:

吴一菡, 雷章, 卢宏达. MUC16/CA125在良恶性肿瘤诊治中的作用及其研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(05): 591-595.

Yihan Wu, Zhang Lei, Hongda Lu. Progress in understanding of role of MUC16/CA125 in diagnosis and treatment of benign and malignant tumors[J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(05): 591-595.

MUC16/CA125是一种糖类蛋白肿瘤标志物,可来源于间皮细胞组织、米勒管上皮及两者衍生物所发生的良恶性疾病。MUC16/CA125在良恶性肿瘤中的作用不同,一方面,通过MUC16-siglec-9、MUC16-galectin-1/3、MUC16-Mesothelin、MUC16-选择素和MUC16-JAK2等信号通路参与恶性肿瘤的发生发展、侵袭和转移,另一方面,其在非恶性肿瘤中主要起到了局部缓冲、润滑、抗炎及维持内环境稳态的功能。本文针对于血清CA125升高相关疾病的鉴别进行了讨论,以及MUC16/CA125可能作为新型特异性肿瘤标志物和更多的新型靶向药物进行了阐述。

MUC16/CA125 is a kind of glycoprotein tumor marker that can originate from mesothelial cells, Miller duct epithelium in benign tissue, and their derivatives in malignant diseases. MUC16/CA125 has different roles in benign and malignant tumors. On the one hand, it participates in the occurrence and development of malignant tumors through signaling pathways such as MUC16-siglec-9, MUC16-galectin-1/3, MUC16-mesothelin, MUC16-selectin, and MUC16-JAK2. On the other hand, it mainly has the functions of local buffering, lubrication, anti-inflammation, and maintaining homeostasis in non-malignant tumors. In this paper, we discuss the identification of diseases related to elevated serum CA125 and its role in the diagnosis and treatment of benign and malignant tumors. Further research is needed to explore MUC16/CA125 as a new specific tumor marker and target for new drugs.

1
Tang Y, Cui Y, Zhang S, et al. The sensitivity and specificity of serum glycan-based biomarkers for cancer detection [J]. Prog Mol Biol Transl Sci, 2019, 162: 121-140.
2
Bast RC, Feeney M, Lazarus H, et al. Reactivity of a monoclonal antibody with human ovarian carcinoma [J]. J Clin Invest, 1981, 68(5): 1331-1337.
3
O'brien T, Beard J, Underwood L, et al. The CA125 gene: an extracellular superstructure dominated by repeat sequences [J]. Tumor Biol, 2001, 22(6): 348-366.
4
Tolman CJ, Vaid T, Schreuder HWR. Extremely elevated CA125 in benign ovarian disease due to stretch of the peritoneum [J]. BMJ, 2012, 2012: bcr2012006664.
5
Kabawat SE, Bast RC, Bhan AK, et al. Tissue distribution of a coelomic-epithelium-related antigen recognized by the monoclonal antibody OC125 [J]. Int J Gynecol Pathol, 1983, 2(3): 275-285.
6
Das S, Batra S. Understanding the unique attributes of MUC16 (CA125): potential implications in targeted therapy [J]. Cancer Res, 2015, 75(22): 4669-4674.
7
范艳佳, 陈美红, 颜林林. 化学发光免疫法在肿瘤生物标志物检测中的应用价值 [J]. 实用预防医学, 2021, 28(11): 1397-1400.
8
Li J, Wang X, Qu W, et al. Comparison of serum human epididymis protein 4 and CA125 on endometrial cancer detection: a meta-analysis [J]. Clin Chim Acta, 2019, 488: 215-220.
9
Rao TD, Tian H, Ma X, et al. Expression of the carboxy-terminal portion of MUC16/CA125 induces transformation and tumor invasion [J]. PLoS One, 2015, 10(5): e0126633.
10
Das S, Majhi PD, Al-Mugotir MH, et al. Membrane proximal ectodomain cleavage of MUC16 occurs in the acidifyingGolgi/post-Golgi compartments [J]. Sci Rep, 2015, 5(1): 1-11.
11
Lee DH, Choi S, Park Y, et al. Mucin1 and mucin16: The rapeutic targets for cancer therapy [J]. Pharmaceuticals, 2021, 14(10): 1053.
12
Akita K, Tanaka M, Tanida S, et al. CA125/MUC16 interacts with Src family kinases, and over-expression of its C-terminal fragment in human epithelial cancer cells reduces cell-cell adhesion [J]. Eur J Cell Biol, 2013, 92(8-9): 257-263.
13
Nomoto M, Konopaske GT, Yamashita N, et al. Clinical evidence that a dysregulated master neural network modulator may aid in diagnosing schizophrenia [J]. Proc Natl Acad Sci U S A, 2021, 118(31): e2100032118.
14
Schummer M, Ng WV, Bumgarner RE, et al. Comparative hybridization of an array of 21 500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas [J]. Gene, 1999, 238(2): 375-385.
15
黄可, 徐娟, 贾雪梅. 卵巢癌相关糖蛋白分子标志物及其促癌机制的研究进展 [J]. 肿瘤学杂志, 2020, 26(9): 833-837.
16
王兰兰, 焦凤琴. 人附睾分泌蛋白4联合血清CA125检测诊断卵巢癌的价值 [J]. 中国妇幼保健, 2018, 33(6): 1237-1238.
17
Dochez V, Caillon H, Vaucel E, et al. Biomarkers and algorithms for diagnosis of ovarian cancer: CA125, HE4, RMI and ROMA, a review [J]. J Ovarian Res, 2019, 12(1): 28.
18
Jacobs I, Oram D, Fairbanks J, et al. A risk of malignancy index incorporating CA125, ultrasound and menopausal status for the accurate preoperative diagnosis of ovarian cancer [J]. BJOG, 1990, 97(10): 922-929.
19
Moore RG, Mcmeekin DS, Brown AK, et al. A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass [J]. Gynecol Oncol, 2009, 112(1): 40-46.
20
Karlsen MA, Høgdall EVS, Christensen IJ, et al. A novel diagnostic index combining HE4, CA125 and age may improve triage of women with suspected ovarian cancer - An international multicenter study in women with an ovarian mass [J]. Gynecol Oncol, 2015, 138(3): 640-646.
21
Moore RG, Brown A K, Miller MC, et al. Utility of a novel serum tumor biomarker HE4 in patients with endometrioid adenocarcinoma of the uterus [J]. Gynecol Oncol, 2008, 110 (2): 196-201.
22
孙艳艳, 井水, 杨大平, 等. 子宫内膜癌患者血清CA125、CA199、SCC-Ag表达水平及其临床意义 [J]. 医学综述, 2022, (3): 615-618, 624.
23
尹利娟, 陈龙梅. CA125在呼吸科疾病中的诊断价值 [J]. 医学信息, 2020, 33(19): 165-167, 170.
24
张波, 李明东, 单立群. 非小细胞肺癌患者血清可溶性B7-H4的表达及其与临床病理特征的关系 [J]. 中国基层医药, 2017, 24(13): 1965-1969.
25
Hatzakis KD, Froudarakis ME, Bouros D, et al. Prognostic value of serum tumor markers in patients with lung cancer [J]. Respiration, 2002, 69(1): 25-29.
26
李标, 张有为. CRP、CEA及CA125表达水平与非小细胞肺癌患者行VATS术后疗效及预后的相关性 [J]. 临床肺科杂志, 2020, 25(5): 724-729.
27
Li Z, Zhao J. Clinical efficacy and safety of crizotinib and alectinib in ALK-positive non-small cell lung cancer treatment and predictive value of CEA and CA125 for treatment efficacy [J]. Am J Transl Res, 2021, 13(11): 13108-13116.
28
Wang J, Chu Y, Li J, et al. Development of a prediction model with serum tumor markers to assess tumor metastasis in lung cancer [J]. Cancer Med, 2020, 9(15): 5436-5445.
29
Ma S, Shen L, Qian N, et al. The prognostic values of CA125, CA199, NSE, AND SCC for stage I NSCLC are limited [J]. Cancer Biomark, 2011, 10(3-4): 155-162.
30
Chu L, Peng Y, Weng X, et al. Blood-based biomarkers for early detection of esophageal squamous cell carcinoma [J]. World J Gastroenterol, 2020, 26(15): 1708-1725.
31
李田田, 薛文华, 秦迁, 等. 糖类抗原125、癌胚抗原和神经特异性烯醇酶联合检测在食管鳞癌诊断中的应用价值 [J]. 肿瘤基础与临床, 2021, 34(4): 311-313.
32
亢晓春, 张清琴, 陆志红, 等. CA125、CA50、CEA在贲门癌患者体内变化意义研究 [J]. 齐齐哈尔医学院学报, 2021, 42(10): 838-840.
33
翁艳, 褚云香, 王东盛, 等. CEA、CA125、CA19-9对胃癌的诊断价值及与TNM分期、淋巴结转移的关系 [J]. 癌症进展, 2019, 17(5): 582-584.
34
王章奇, 杨俊, 彭享, 等. 血清HIF-1α、CA125、CEA、CA19-9联合检测对结直肠癌患者术后早期复发转移的预测价值 [J]. 中国医药科学, 2019, 9(6): 7-10.
35
Kwanpeemai P, Andrew D. Diagnostic and prognostic role of peritoneal CA125 in peritoneal dialysis patients presenting with acute peritonitis [J]. BMC Nephrol, 2014, 15: 149.
36
袁昌丽, 段秀清, 喻昆林. 以CA125升高的结核性腹膜炎一例 [J]. 云南医药, 2021, 42(05): 507-508, 496.
37
黎增辉. 血清AFP-L3%、CA125、CA199和IL-6变化与乙肝后肝硬化和癌变的相关性研究 [J]. 临床输血与检验, 2019, 21(5): 535-539.
38
聂荣慧, 刘元元. 肿瘤标志物AFP、CA125、CA199和CEA检测在肝炎、肝硬化患者诊断和治疗中的应用 [J]. 吉林大学学报(医学版), 2012, 38(1): 119-122.
39
Kayadibi H, Sertoglu E, Uyanik M. Evaluation of relationship between CA125 levels and ascites in patients with liver cirrhosis [J]. J Coll Physicians Surg Pak, 2014, 24(11): 873.
40
朱壹澎, 卢高峰, 孙趁意, 等. 肝硬化患者血清CA125水平升高的相关因素分析 [J]. 中国全科医学, 2019, 22(21): 2577-2581.
41
王雯, 徐婷, 孙甜甜, 等. 类风湿关节炎合并活动性肺结核病的临床特征及相关因素分析 [J]. 中国感染与化疗杂志, 2021, 21(2): 158-164.
42
高见, 纪青. 不典型与典型肺结核痰抗酸杆菌、糖类抗原125、D-二聚体、腺苷脱氨酶检测结果对比 [J]. 中国现代医药杂志, 2021, 23(12): 26-29.
43
杨建和, 张蔚华. CA125在恶性及结核性胸水中鉴别诊断价值的探讨 [J]. 医师进修杂志, 2000, (7): 27-28.
44
何彦侠, 薛兵, 赵淑敏. 癌抗原125在常见非恶性呼吸疾病中的应用研究进展 [J]. 2015, 50(10): 48-50.
45
王颖颖. 冠心病患者血清CA125、CysC、OPG中的水平变化及意义 [J]. 中国卫生工程学, 2021, 20(5): 839-840.
46
胡欣, 李月芳, 赵红, 等. 高龄慢性心力衰竭患者血清CA125、尿酸水平与心功能的相关性 [J]. 心血管康复医学杂志, 2018, 27(1): 12-15.
47
Hamdy NM. Relationship between pro-anti-inflammatory cytokines, T-cell activation and CA125 in obese patients with heart failure [J]. Med Sci Monit, 2011, 17(3): CR173.
48
Huang F, Chen J, Liu Y, et al. New mechanism of elevated CA125 in heart failure: the mechanical stress and inflammatory stimuli initiate CA125 synthesis [J]. Med Hypotheses, 2012, 79(3): 381-383.
49
Núñez J, Minana G, Núñez E, et al. Clinical utility of antigen carbohydrate 125 in heart failure [J]. Heart Fail Rev, 2014, 19(5): 575-584.
50
戈程, 李佳月, 刘博罕, 等. 心肌淀粉样变性临床特点及远期预后的影响因素 [J]. 中华老年多器官疾病杂志, 2020, 19(6): 405-409.
51
古晓燕, 龚德华. 慢性肾脏病患者血清肿瘤标志物检测的意义 [J]. 中国血液净化, 2020, 19(10): 699-702.
52
齐娟飞, 朱海燕. 月经周期对CA125的影响 [J]. 母婴世界, 2015, 1(2): 125.
53
Kafali H, Artunc H, Erdem M. Evaluation of factors that may be responsible for cyclic change of CA125 levels during menstrual cycle [J]. Arch Gynecol Obstet, 2007, 3(275): 175-177.
54
Spitzer M, Kaushal N, Benjamin F. Maternal CA125 levels in pregnancy and the puerperium [J]. J Reprod Med, 1998, 43(4): 387-392.
55
邹晓静, 朱诗呈, 李春梅. 温州地区孕妇CA125参考区间的建立及应用 [J]. 放射免疫学杂志, 2012, 25(4): 474-475.
56
王宜生. CA125升高患者的良恶性鉴别方法研究 [博士学位论文]. 上海: 复旦大学, 2012.
57
White B, Patterson M, Karnwal S, et al. Crystal structure of a human MUC16 SEA domain reveals insight into the nature of the CA125 tumor marker [J]. Proteins, 2022, 90(5): 1210-1218.
58
Brewer M, Angioli R, Scambia G, et al. Front-line chemo-immunotherapy with carboplatin-paclitaxel using oregovomab indirect immunization in advanced ovarian cancer: A randomized phase II study [J]. Gynecol Oncol, 2020, 156(3): 523-529.
59
Reinartz S, Köhler S, Schlebusch H, et al. Vaccination of patients with advanced ovarian carcinoma with the anti-idiotype ACA125: immunological response and survival (phase Ib/II) [J]. Clin Cancer Res, 2004, 10(5): 1580-1587.
60
Liu JF, Moore KN, Birrer MJ, et al. Phase I study of safety and pharmacokinetics of the anti-MUC16 antibody-drug conjugate DMUC5754A in patients with platinum-resistant ovarian cancer or unresectable pancreatic cancer [J]. Ann Oncol, 2016, 27(11): 2124-2130.
[1] 张晓燕, 肖东琼, 高沪, 陈琳, 唐发娟, 李熙鸿. 转录因子12过表达对脓毒症相关性脑病大鼠大脑皮质的保护作用及其机制[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 540-549.
[2] 周美岑, 王华, 母得志. 早产儿疫苗预防接种及时性[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(03): 261-266.
[3] 张永博, 张亮, 陈浏阳, 戴睿, 孙华, 杨盛, 孟博, 彭晴. 线粒体与椎间盘退变[J]. 中华损伤与修复杂志(电子版), 2023, 18(03): 265-269.
[4] 樊逸隽, 杨枫, 王玮, 殷鹤英, 刘俊. 喉前淋巴结转移对甲状腺乳头状癌诊疗价值的研究进展[J]. 中华普通外科学文献(电子版), 2023, 17(04): 306-310.
[5] 张林, 刘芳, 赵静, 刘勇, 周青. 远程康复在慢性阻塞性肺疾病患者肺康复中的研究进展[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 601-604.
[6] 李丹阳, 李满祥. 肠道菌群失调在肺动脉高压发病中的研究进展[J]. 中华肺部疾病杂志(电子版), 2023, 16(03): 432-434.
[7] 刘小燕, 龙乾发, 席俊秀, 杜明皓, 黄晓欢. 细胞外囊泡介导的胶质细胞交互作用对神经炎症的调节意义及研究进展[J]. 中华细胞与干细胞杂志(电子版), 2023, 13(04): 235-241.
[8] 秦富豪, 郑正, 江滨. 间充质干细胞在克罗恩病肛瘘治疗中的研究进展[J]. 中华细胞与干细胞杂志(电子版), 2023, 13(03): 172-177.
[9] 李翠平, 陈晓燕, 钱师宇, 林惠珠, 曾彩辉, 阳莉, 卢建溪. 不同抗凝剂保存液对脐血培养的NK细胞增殖及杀伤效应的影响[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 572-576.
[10] 蓝冰, 王怀明, 王辉, 马波. 局部晚期结肠癌膀胱浸润的研究进展[J]. 中华结直肠疾病电子杂志, 2023, 12(06): 505-511.
[11] 李峻, 林莉, 王俭梅, 李芬, 刘莉莉, 汪星玉, 丁洁. 黄芪当归贴膏对维持性血液透析患者自体动静脉内瘘的保护作用[J]. 中华肾病研究电子杂志, 2023, 12(02): 87-92.
[12] 黄文鹏, 邱永康, 杨琦, 宋乐乐, 陈钊, 范岩, 康磊. PET相关影像组学在肿瘤预后中的研究进展[J]. 中华消化病与影像杂志(电子版), 2023, 13(02): 104-110.
[13] 王雪, 徐佳音, 廖丽娟, 黄干荣, 黄永毅, 韦贤, 黄衍强, 黄亮. 大黄素提高新生隐球菌琥珀酸脱氢酶活性增强氧化作用的研究[J]. 中华临床医师杂志(电子版), 2023, 17(03): 314-319.
[14] 王昊, 明倩文, 王斌, 卢太坤, 张海宁. 利奈唑胺致黑毛舌的临床诊断学特征[J]. 中华诊断学电子杂志, 2023, 11(04): 254-260.
[15] 廖安琪, 王玫, 廖远泉. 达格列净诱发糖尿病患者血尿发生的临床诊断特征[J]. 中华诊断学电子杂志, 2023, 11(03): 169-172.
阅读次数
全文


摘要