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中华临床医师杂志(电子版) ›› 2023, Vol. 17 ›› Issue (07) : 828 -833. doi: 10.3877/cma.j.issn.1674-0785.2023.07.012

综述

肠道微生物群对代谢相关脂肪性肝病发展的影响
张大涯, 陈世锔, 陈润祥, 张晓冬, 李达, 白飞虎()   
  1. 571199 海口,海南医学院研究生院
    570216 海口,海南医学院第二附属医院消化内科;570216 海口,海南省消化疾病临床研究中心
  • 收稿日期:2023-01-17 出版日期:2023-07-15
  • 通信作者: 白飞虎
  • 基金资助:
    海南省临床医学中心建设项目资助(2021818); 海南省院士团队创新中心建设项目资助(2022136); 海南省院士创新平台科研项目资金资助(YSPTZX202313); 海南省卫生健康行业科研项目资助(22A200078); 海南省研究生创新科研课题(Qhyb2022-133); 海南医学院研究生创新科研课题(HYYB2022A18)

Role of intestinal microecological dysregulation in development of metabolic-associated fatty liver disease

Daya Zhang, Shiju Chen, Runxiang Chen, Xiaodong Zhang, Da Li, Feihu Bai()   

  1. Graduate School, Hainan Medical University, Haikou 571199, China
    Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, Haikou 570216, China; The Gastroenterology Clinical Medical Center of Hainan Province, Haikou 570216, China
  • Received:2023-01-17 Published:2023-07-15
  • Corresponding author: Feihu Bai
引用本文:

张大涯, 陈世锔, 陈润祥, 张晓冬, 李达, 白飞虎. 肠道微生物群对代谢相关脂肪性肝病发展的影响[J/OL]. 中华临床医师杂志(电子版), 2023, 17(07): 828-833.

Daya Zhang, Shiju Chen, Runxiang Chen, Xiaodong Zhang, Da Li, Feihu Bai. Role of intestinal microecological dysregulation in development of metabolic-associated fatty liver disease[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(07): 828-833.

代谢相关脂肪性肝病(MAFLD)是一种严重威胁公众健康的疾病,其发病机制尚不清楚。肠道微生物群及其代谢产物对MAFLD的发展有重要影响。在这篇综述中,笔者主要强调肠道微生物群及其代谢产物影响MAFLD的关键机制,并阐述了通过益生菌、益生元、合生元和粪菌移植(FMT)调节肠道微生物群来治疗MAFLD的研究。

Metabolic-associated fatty liver disease (MAFLD) is a serious public health threat and its pathogenesis is still not completely clear. Studies have shown that the intestinal microbiota and its metabolites have an important role in the development of MAFLD. In this review, we focus on the key mechanisms by which the intestinal microbiota and its metabolites influence MAFLD. In addition, we also discuss the treatment of MAFLD by modulating the intestinal microbiota through probiotics, prebiotics, synbiotics, and fecal microbiota transplantation.

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