以雷公藤属雷公藤、昆明山海棠、东北雷公藤三味中药为基础，整合其中药及复方知识，以现有文献型数据库、药代动力学和毒性在线预测平台（ADMETlab 2.0数据库）、中药系统药理数据库（TCMSP数据库）、中医药百科全书（ETCM数据库）以及2020版《中国药典》为数据整理制作基础数据库，并对数据库内容进行重新关联及建设。雷公藤属数据库（TWD）共收集相关中成药方剂14首，方剂相关药材53味，相关化学成分4 000余个，相关疾病靶标2 000余个，相关疾病20种，内容涵盖药材产地、性味归经、指标成分、配伍禁忌、现代应用等多个维度。包括药材、方剂、成分、靶标、疾病5个子数据库及1个分析系统，通过主数据库与二级表建立超链接，实现各个数据库表数据的交互检索。通过整理、融合专业知识，结合数据库的专业前沿技术，使用中英文对照形式建立的TWD，将雷公藤属的中药信息系统、准确、全面、综合、可视化地呈现，为雷公藤属植物药的开发与临床应用奠定基础，推动雷公藤属领域研究国际化。

Being based on the three traditional Chinese medicines Tripterygium wilfordii Hook. f., Tripterygium hypoglaucum (Levl.) Hutch, and Tripterygium regelii Spragus et Takeda, integrating the knowledge of Chinese medicines and compound prescriptions, and combining the data from the existing literature database, ADMETlab 2.0 database, Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform database (TCMSP), The Encyclopedia of Traditional Chinese Medicine database (ETCM), and the 2020 edition of Chinese Pharmacopoeia, a basic database was generated. Then, the database content was re-associated and constructed. The Tripterygium wilfordii database (TWD) collects a total of 14 related Chinese patent medicine prescriptions, 33 related medicinal materials, more than 4000 related chemical components, more than 2000 related disease targets, and 20 related diseases, covering the origin of medicinal materials, flavor and meridian tropism, index components, incompatibility, modern application, and other dimensions. It includes five sub-databases of medicinal materials, prescriptions, ingredients, targets, and diseases and one analysis system. Hyperlinks are established between the primary database and the secondary table to realize the interactive retrieval of data from each database table. By collation and integration of professional knowledge, combined with the professional frontier technology of the database, the TWD was established in a bilingual (Chinese-English) form, presenting the traditional Chinese medicine information of Tripterygium wilfordii systematically, accurately, comprehensively, synthetically, and visually, laying the foundation for the development and clinical application of Tripterygium wilfordii botanical drugs and promoting the internationalization of Tripterygium wilfordii research.