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中华临床医师杂志(电子版) ›› 2024, Vol. 18 ›› Issue (01) : 19 -23. doi: 10.3877/cma.j.issn.1674-0785.2024.01.004

临床研究

甲状腺微小乳头状癌风险度分级及术式选择的探讨148例
邱衍哲1, 董志伟1, 王妍1, 顾国利1,()   
  1. 1. 100142 北京,空军特色医学中心普通外科
  • 收稿日期:2023-10-22 出版日期:2024-01-15
  • 通信作者: 顾国利

Discussion on risk classification and surgical selection in papillary thyroid microcarcinoma: analysis of 148 cases

Yanzhe Qiu1, Zhiwei Dong1, Yan Wang1, Guoli Gu1,()   

  1. 1. Department of General Surgery, Air Force Medical Center, Beijing 100142, China
  • Received:2023-10-22 Published:2024-01-15
  • Corresponding author: Guoli Gu
引用本文:

邱衍哲, 董志伟, 王妍, 顾国利. 甲状腺微小乳头状癌风险度分级及术式选择的探讨148例[J]. 中华临床医师杂志(电子版), 2024, 18(01): 19-23.

Yanzhe Qiu, Zhiwei Dong, Yan Wang, Guoli Gu. Discussion on risk classification and surgical selection in papillary thyroid microcarcinoma: analysis of 148 cases[J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(01): 19-23.

目的

探讨甲状腺微小乳头状癌(PTMC)的风险度分级,并提供选择适宜术式的参考依据。

方法

回顾性分析空军特色医学中心普通外科2019.12~2022.12期间手术的148例经病理证实的PTMC患者的临床资料。总结术前超声、手术方式、术中和术后病理结果,综合分析后得出PTMC风险度分级标准,并指导术式选择。

结果

148例PTMC患者淋巴结转移率40.5%,77例单发PTMC组19.5%,71例多发PTMC组为63.4%,差异具有统计学意义。术前超声诊断颈部淋巴结转移的准确率为75.0%、敏感度84.9%,多发PTMC的准确率为80.3%。以术前超声和术中冰冻病理结果将入组病例分为低风险组和高风险组,61例低风险组PTMC患者的淋巴结转移率为4.9%,87例高风险组为65.5%,差异具有统计学意义。

结论

术前高质量的超声检查和术中冰冻病理可以作为术式选择的重要指导指标。以此分类的低风险组行甲状腺腺叶+峡部切除和高风险组行甲状腺全切+患侧区域淋巴结清扫是适宜的。

Objective

To explore the risk classification of papillary thyroid microcarcinoma (PTMC), and to provide reference for selecting the appropriate surgical method.

Methods

The clinical data of 148 PTMC patients admitted to our department from December 2019 to December 2022 were retrospectively analyzed. The results of preoperative ultrasonography, surgical methods, and intraoperative and postoperative pathological reports were summarized to obtain the risk classification of PTMC to select the appropriate surgical method.

Results

The rate of lymph node metastasis was 40.5% in the total 148 PTMC patients, 19.5% in the 77 patients with single PTMC, and 63.4% in the 71 patients with multiple PTMC; the difference between the latter two groups was statistically significant. The accuracy and sensitivity of preoperative ultrasonography for diagnosing neck lymph node metastasis were 75.0% and 84.9%, respectively, and the accuracy for diagnosing multiple PTMC was 80.3%. We used preoperative ultrasonography and intraoperative frozen pathology as the classification indicators. The rate of lymph node metastasis was 4.9% in 61 low-risk PTMC patients, and 65.5% in 87 high-risk PTMC patients; the difference was statistically significant.

Conclusion

High-quality preoperative ultrasonography and accurate intraoperative frozen pathology can provide reliable information for the selection of appropriate surgical procedure. According to this classification, it is appropriate to perform thyroid lobe + isthmus resection in the low-risk group and total thyroid resection + affected lymph node dissection in the high-risk group.

表1 PTMC单发组与多发组、单发≤0.5 cm组与单发>0.5 cm组、单侧多发组与双侧多发组淋巴结转移率的比较
表2 PTMC单发伴淋巴结转移组与多发伴淋巴结转移组术前超声准确率的比较
表3 PTMC低风险型组与高风险型组、低风险型≤0.5 cm组与低风险型>0.5 cm组淋巴结转移率的比较
1
田文, 郗洪庆. 甲状腺癌病人生存现状分析[J]. 中国实用外科杂志, 2016, 36(5): 489-493.
2
Siegel R, Naishadham D, Jemal A. Cancer statistics 2010[J]. CA Cancer, 2012, 44(1): 11-24.
3
Wiltshire JJ, Drake TM, Uttley L, et al. Systematic review of trends in the Incidences rates of thyroid cancer[J]. Thyroid, 2016, 26(11): 1541-1552.
4
周爱香, 王玉恒, 杨莱姣, 等. 甲状腺微小癌高频超声影像学特征及诊断价值[J]. 军医进修学院学报, 2012, 33(7): 725-727.
5
Lee JH, Baek JH, Kim JH, et al. Deep learning-based computer-aided diagnosis system for localization and diagnosis of metastatic lymph nodes on ultrasound : a pilot study[J]. Thyroid, 2018, 28(10): 1332-1338.
6
Roach JC, Heller KS, Dubner S, et al. The value of frozen section examinations in determining the extent of thyroid surgery in patients with indeterminate fine-needle aspiration cytology[J]. Arch Otolaryngol Head Neck Surg, 2002, 128(3): 263-267.
7
陈淑良. 甲状腺微小乳头状癌的临床病理研究 [D]. 大连: 大连医科大学, 2015: 19.
8
Ito Y, Miyauchi A, Kudo T, et al. Trends in the implementation of active surveillance for low-risk papillary thyroid microcarcinomas at Kuma Hospital: gradual increase and heterogeneity in the acceptance of this new management option[J]. Thyroid, 2018, 28(4): 488-495.
9
Leboulleux S, Tuttle RM, Pacini F, Schlumberger M. Papillary thyroid microcarcinoma: time to shift from surgery to active surveillance?[J]. Lancet Diabetes Endocrinol, 2016, 4(11): 933-942.
10
向俊, 吴毅. 甲状腺癌临床诊治新特点[J]. 中国实用外科杂志, 2008, 28(5): 365-367.
11
陈贵进, 王春喜, 李胜君. 88例甲状腺微小乳头状癌诊治分析[J]. 军医进修学院学报, 2013, 34(5): 449-457.
12
Zheng W, Li J, Lv P, et al. Treatment efficacy between total thyroidectomy and lobectomy for patients with papillary thyroid microcarcinoma: a systemic review and meta-analysis[J]. Eur J Surg Oncol, 2018, 44(11): 1679-1684.
13
Wada N, Duh QY, Sugino K, et al. Lymph node metastasis from 259 papillary thyroid microcarcinomas: frequency, pattern of occurrence and recurrence, and optimal strategy for neck dissection[J]. Ann Surg, 2003, 237(3): 399-407.
14
Roh JL, Kim JM, Park CI. Central cervical nodal metastasis from papillary thyroid microcarcinoma: pattern and factors predictive of nodal metastasis[J]. Ann Surg Oncol, 2008, 15(9): 2482-2486.
15
王丹, 张颖毅, 宋永蔚. cN0期甲状腺微小乳头状癌行Ⅵ区淋巴结清扫的临床意义[J]. 吉林医学, 2013, 34(15): 2983-2984.
16
薛帅. 甲状腺微小乳头状癌侧颈淋巴结转移的准确诊治体系的研究 [D]. 长春:吉林大学, 2020: 6-11.
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