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中华临床医师杂志(电子版) ›› 2024, Vol. 18 ›› Issue (02) : 133 -138. doi: 10.3877/cma.j.issn.1674-0785.2024.02.004

所属专题: 临床药学

临床研究

630 nm激光联合血卟啉衍生物治疗晚期支气管肺癌的近期临床疗效分析
李林宇1, 崔世超1, 杨晓晖1, 曹艺巍1, 林存智1,()   
  1. 1. 266400 山东 青岛,青岛大学附属医院呼吸与危重症医学科
  • 收稿日期:2023-12-08 出版日期:2024-02-15
  • 通信作者: 林存智

Short-term clinical efficacy of 630 nm laser combined with hematoporphyrin derivatives in treatment of advanced bronchial lung cancer

Linyu Li1, Shichao Cui1, Xiaohui Yang1, Yiwei Cao1, Cunzhi Lin1,()   

  1. 1. Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Qingdao University, Qingdao 266400, China
  • Received:2023-12-08 Published:2024-02-15
  • Corresponding author: Cunzhi Lin
引用本文:

李林宇, 崔世超, 杨晓晖, 曹艺巍, 林存智. 630 nm激光联合血卟啉衍生物治疗晚期支气管肺癌的近期临床疗效分析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(02): 133-138.

Linyu Li, Shichao Cui, Xiaohui Yang, Yiwei Cao, Cunzhi Lin. Short-term clinical efficacy of 630 nm laser combined with hematoporphyrin derivatives in treatment of advanced bronchial lung cancer[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(02): 133-138.

目的

探讨630 nm激光联合血卟啉衍生物治疗晚期支气管肺癌的近期临床疗效及安全性。

方法

选择青岛大学附属医院2019年3月至2023年9月经病理确诊的43例晚期支气管肺癌患者,行支气管肺癌介入治疗后,联合630 nm激光和血卟啉衍生物及化疗、免疫治疗。随访患者基本临床特征及治疗后的不良反应,治疗后1个月复查胸部CT及支气管镜检查。

结果

胸部CT显示治疗后气管或支气管内肿瘤体积较术前明显缩小,改善通气。支气管镜检查显示,治疗后肿瘤体积减小,甚至消失。治疗1个月后按时复查胸部CT及支气管镜检查的患者为31例(72.09%),31例患者的总有效率70.97%。43例患者均未出现严重并发症,但3例患者出现常见并发症。

结论

630 nm激光联合血卟啉衍生物治疗晚期支气管肺癌近期临床疗效明显,能改善气道狭窄,缓解呼吸困难、咳嗽等症状,安全性好,值得在临床推广应用。

Objective

To analyze the short-term clinical efficacy and safety of 630 nm laser combined with hematoporphyrin derivatives in the treatment of advanced bronchial lung cancer.

Methods

A total of 43 patients with pathologically diagnosed bronchial lung cancer who underwent interventional tumor reduction combined with treatment with 630 nm laser and hematoporphyrin derivatives, chemotherapy, and immunotherapy were selected at the Affiliated Hospital of Qingdao University from March 2019 to September 2023. The basic clinical features and adverse reactions after treatment were recorded, and chest CT and bronchoscopy were reviewed 1 month after treatment.

Results

Chest CT showed that the tumor volume in the trachea or bronchus was significantly reduced after treatment, and ventilation was improved. Bronchoscopy showed that the tumor volume decreased or even disappeared after treatment. After 1 month of treatment, 31 patients (72.09%) were re-examined by chest CT and bronchoscopy, and the total effective rate was 70.97%. None of the 43 patients had serious complications, but 3 patients had common complications.

Conclusion

630 nm laser combined with hematoporphyrin derivatives has obvious clinical efficacy in the treatment of advanced bronchial lung cancer, and it can improve airway stenosis and relieve dyspnea, cough, and other symptoms with a favorable safety profile.

表1 患者临床基本特征
表2 PDT近期疗效比较
图1 肺癌患者肺部增强CT图像。图a和d为治疗前左肺上叶增强CT图像;图b和e为光动力治疗后1个月的CT图像;图c和f为光动力治疗后3个月的CT图像
图2 肺癌患者支气管镜视图。图a为治疗前左上叶支气管镜下的新生物视图;图b为光动力治疗后左上叶支气管镜视图;图c为治疗一个月后左上叶支气管镜视图
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