切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2024, Vol. 18 ›› Issue (10) : 943 -948. doi: 10.3877/cma.j.issn.1674-0785.2024.10.010

综述

抗合成酶综合征发病机制及氨酰基tRNA 合成酶功能的应用研究进展
宣丹1, 谈文峰2,()   
  1. 1.241000 安徽芜湖,皖南医学院第一附属医院风湿免疫科
    2.210029 江苏南京,南京医科大学第一附属医院风湿免疫科
  • 收稿日期:2024-10-15 出版日期:2024-10-15
  • 通信作者: 谈文峰
  • 基金资助:
    国家自然科学基金(82171794)安徽省教育厅质量工程项目(2023jxxm1217)

Progress in applied research of pathogenesis of antisynthase syndrome and function of aminoacyl-tRNA synthetase

Dan Xuan1, Wenfeng Tan2,()   

  1. 1.Department of Rheumatology and Immunology, The First Affiliated Hospital of Wannan Medical College, Wuhu 241001, China
    2.Department of Rheumatology and Immunology,The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:2024-10-15 Published:2024-10-15
  • Corresponding author: Wenfeng Tan
引用本文:

宣丹, 谈文峰. 抗合成酶综合征发病机制及氨酰基tRNA 合成酶功能的应用研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(10): 943-948.

Dan Xuan, Wenfeng Tan. Progress in applied research of pathogenesis of antisynthase syndrome and function of aminoacyl-tRNA synthetase[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(10): 943-948.

抗合成酶综合征是特发性炎性肌病的一种类型,患者血清中可检测抗氨酰基tRNA 合成酶抗体,临床可表现关节炎、肌炎、间质性肺病三联征,ILD 亦可为首发,但其发病机制仍不十分明确。总结ASS 可能的发病机制、常见几种靶抗原及其功能、抗ARS 抗体的作用及不同抗体亚型的临床特征,为了解疾病发病机制及临床诊治提供一些参考。

Antisynthetase syndrome (ASS) is a subtype of idiopathic inflammatory myopathy.Anti-aminoacyl-tRNA synthetase antibodies can be detected in the serum of ASS patients.ASS may clinically manifest as arthritis, myositis, and interstitial lung disease (ILD).ILD can also be the first manifestation of the ASS, but its pathogenesis is still not very clear.This paper summarizes the possible pathogenesis of ASS, several common target antigens and their functions, the role of anti-ARS antibodies, and the clinical characteristics of different antibodies, in order to help other clinicians understand the pathogenesis and clinical diagnosis and treatment of this disease.

1
Chinoy H, Adimulam S, Marriage F, etal.Interaction of HLADRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: a European-wide case study[J].Ann Rheum Dis, 2012, 71(6): 961-965.
2
Svensson J, Holmqvist M, Lundberg IE, et al.Infections and respiratory tract disease as risk factors for idiopathic inflammatory myopathies: a population-based case-control study [J].Ann Rheum Dis, 2017, 76(11): 1803-1808.
3
Sciorati C, Monno A, Doglio MG, et al.Exacerbation of murine experimental autoimmune myositis by toll-like receptor 7/8 [J].Arthritis Rheumatol, 2018, 70(8): 1276-1287.
4
Rothwell S, Chinoy H, Lamb JA, et al.Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups [J].Ann Rheum Dis, 2019, 78(7): 996-1002.
5
Chinoy H, Lamb JA, Ollier WER, et al.Recent advances in the immunogenetics of idiopathic inflammatory myopathy [J].Arthritis Res Ther, 2011, 13(3): 216.
6
Remuzgo-Martínez S, Atienza-Mateo B, Ocejo-Vinyals JG, et al.Role of MUC1 rs4072037 polymorphism and serum KL-6 levels in patients with antisynthetase syndrome [J].Sci Rep, 2021, 11(1): 22574.
7
Sakamoto N, Ishimoto H, Kakugawa T, et al.Elevated a-defensin levels in plasma and bronchoalveolar lavage fluid from patients with myositis-associated interstitial lung disease [J].BMC Pulm Med,2018, 18(1): 44.
8
Zhang S, Shu X, Tian X, etal.Enhanced formation and impaired degradation of neutrophil extracellular traps in dermatomyositis and polymyositis: a potential contributor to interstitial lung disease complications [J].Clin Exp Immunol, 2014, 177(1): 134-141.
9
Seto N, Torres-Ruiz JJ, Carmona-Rivera C, et al.Neutrophil dysregulation is pathogenic in idiopathic inflammatory myopathies [J].JCI Insight, 2020, 5(3): e134189.
10
Liu L, Wang J, Zhang P, et al.Promising neutrophil-associated biomarkers in lung diseases of patients with antisynthetase syndrome and dermatomyositis [J].J Immunol Res, 2022, 2022: 1886083.
11
Hervier B, Perez M, Allenbach Y, et al.Involvement of NK cells and NKp30 pathway in antisynthetase syndrome [J].J Immunol, 2016,197(5): 1621-1630.
12
Rossi G, Cavazza A, Spagnolo P, et al.The role of macrophages in interstitial lung diseases: number 3 in the series “pathology for the clinician” edited by peter dorfmuller and alberto cavazza [J].Eur Respir Rev, 2017, 26(145): 170009.
13
González-Pérez MI, Mejía-Hurtado JG, Pérez-Román DI, et al.Evolution of pulmonary function in a cohort of patients with interstitial lung disease and positive for antisynthetase antibodies [J].J Rheumatol, 2020, 47(3): 415-423.
14
Ueshima E, Fujimori M, Kodama H, et al.Macrophage-secreted TGF-beta1 contributes to fibroblast activation and ureteral stricture after ablation injury [J].Am J Physiol Renal Physiol, 2019, 317(7):F52-F64.
15
Kazankov K, Barrera F, Moller HJ, et al.Soluble CD163, a macrophage activation marker, is independently associated with fibrosis in patients with chronic viral hepatitis B and C [J].Hepatology,2014, 60 (2): 521-530.
16
Liu Z, Kuang W, Zhou Q, et al.TGF-β1 secreted by M2 phenotype macrophages enhances the stemness and migration of glioma cells via the SMAD2/3 signalling pathway [J].Int J Mol Med, 2018, 42(6):3395-3403.
17
Ramos-Martínez E, Falfán-Valencia R, Pérez-Rubio G, et al.Interstitial lung disease progression in patients with anti-aminoacyl transfer-RNA-synthetase autoantibodies is characterized by higher levels of sCD163 [J].Immunol Lett, 2022, 248(8): 56-61.
18
Liossis SC, Bounia CA.Treating autoimmune-related interstitial lung disease with B cell depletion [J].Front Med (Lausanne), 2022, 30(9):937561.
19
Soejima M, Kang EH, Gu X, et al.Role of innate immunity in a murine model of histidyl-transfer RNA synthetase (Jo-1)-mediated myositis [J].Arthritis Rheum, 2011, 63(2): 479-487.
20
Martin A, Shulman MJ, Tsui FW.Epitope studies indicate that histidyltRNA synthetase is a stimulating antigen in idiopathic myositis [J].FASEB J, 1995, 9(12): 1226-1233.
21
Galindo-Feria AS, Albrecht I, Fernandes-Cerqueira C, et al.Proinflammatory histidyl-transfer RNA synthetase-specific CD4+T cells in the blood and lungs of patients with idiopathic inflammatory myopathies [J].Arthritis Rheumatol, 2020, 72(1): 179-191.
22
Krystufková O, Vallerskog T, Helmers SB, et al.Increased serum levels of B cell activating factor (BAFF) in subsets of patients with idiopathic inflammatory myopathies [J].Ann Rheum Dis, 2009, 68(6):836-843.
23
Howard OM, Dong HF, Yang D, et al.Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells[J].J Exp Med, 2002, 196(6): 781-791.
24
Ramos-Martinez E, Falfán-Valencia R, Pérez-Rubio G, et al.Antiaminoacyl transfer-RNA-synthetases (Anti-tRNA) autoantibodies associated with interstitial lung disease: pulmonary disease progression has a persistent elevation of the Th17 cytokine profile [J].J Clin Med,2020, 9(5): 1356.
25
Behrens Pinto GL, Carboni RCS, de Souza FHC, et al.A prospective cross-sectional study of serum IL-17A in antisynthetase syndrome [J].Clin Rheumatol, 2020, 39(9): 2763-2771.
26
Rajendran V, Kalita P, Shukla H, et al.Aminoacyl-tRNA synthetases:Structure, function, and drug discovery [J].Int J Biol Macromol, 2018,111(5): 400-414.
27
Jiang L, Jones J, Yang XL.Human diseases linked to cytoplasmic aminoacyl-tRNA synthetases [J].Enzymes, 2020, 48: 277-319.
28
Soejima M, Kang EH, Gu X, et al.Role of innate immunity in a murine model of histidyl-transfer RNA synthetase (Jo-1)-mediated myositis [J].Arthritis Rheum, 2011, 63(2): 479-487.
29
Jung HJ, Park SH, Cho KM, et al.Threonyl-tRNA synthetase promotes T helper type 1 cell responses by inducing dendritic cell maturation and IL-12 production via an NF-kappaB pathway [J].Front Immunol,2020, 11: 571959.
30
Dai C, Reyes-Ordonez A, You JS, et al.A non-translational role of threonyl-tRNA synthetase in regulating JNK signaling during myogenic differentiation [J].FASEB J, 2021, 35(10): e21948.
31
Zhang H, Yang XL, Sun L.The uniqueness of AlaRS and its human disease connections [J].RNA Biol, 2021, 18(11): 1501-1511.
32
郑婵新, 钟春玖.甘氨酰-tRNA 合成酶相关的遗传性周围神经病研究进展 [J/OL].中华临床医师杂志(电子版), 2009, 3(1): 104-107.
33
Adams RA, Fernandes-Cerqueira C, Notarnicola A, et al.Serumcirculating his-tRNA synthetase inhibits organ-targeted immune responses [J].Cell Mol Immunol, 2021, 18(6): 1463-1475.
34
Kwon NH, Fox PL, Kim S.Aminoacyl-tRNA synthetases as therapeutic targets [J].Nat Rev Drug Discov, 2019, 18(8): 629-650.
35
Park JS, Park MC, Lee KY, etal.Unique N-terminal extension domain of human asparaginyl-tRNA synthetase elicits CCR3-mediated chemokine activity [J].Int J Biol Macromol, 2018, 120(PtA): 835-845.
36
Cavagna L, Trallero-Araguás E, Meloni F, et al.Influence of antisynthetase antibodies specificities on antisynthetase syndrome clinical spectrum time course [J].J Clin Med, 2019, 8(11): 2013.
37
Jiang M, Dong X, Zheng Y.Clinical characteristics of interstitial lung diseases positive to different anti-synthetase antibodies [J].Medicine(Baltimore), 2021, 100(19): e25816.
38
Abel A, Lazaro E, Ralazamahaleo M, et al.Phenotypic profiles among 72 caucasian and afro-caribbean patients with antisynthetase syndrome involving anti-PL7 or anti-PL12 autoantibodies [J].Eur J Intern Med,2023, 115: 104-113.
39
Zhan X, Yan W, Wang Y, et al.Clinical features of anti-synthetase syndrome associated interstitial lung disease: A retrospective cohort in China [J].BMC Pulm Med, 2021, 21(1): 57.
40
Hervier B, Wallaert B, Hachulla E, et al.Clinical manifestations of anti-synthetase syndrome positive for anti-alanyl-tRNA synthetase(Anti-PL12) antibodies: A retrospective study of 17 cases [J].Rheumatology, 2010, 49(5): 972-976.
41
Abel A, Lazaro E, Ralazamahaleo M, et al.Phenotypic profiles among 72 caucasian and afro-caribbean patients with antisynthetase syndrome involving anti-PL7 or anti-PL12 autoantibodies [J].Eur J Intern Med,2023, 115: 104-113.
42
Zhang Y, Ge Y, Yang H, et al.Clinical features and outcomes of the patients with anti-Glycyl tRNA synthetase syndrome [J].Clin Rheumatol, 2020, 39(8): 2417-2424.
43
朱玉静, 王磊, 吕成银, 等.抗EJ 抗体阳性抗合成酶综合征相关间质性肺疾病复发的临床特征分析 [J].北京大学学报(医学版),2024, 56(6): 980-986.
44
周云, 吕成银, 尤含笑, 等.不同抗体亚型抗合成酶综合征并发间质性肺疾病临床特征分析 [J].中华风湿病学杂志, 2024, 28(8):538-544.
45
Ge YP, Zhang YL, Shu XM, et al.Clinical characteristics of antiisoleucyl-tRNA synthetase antibody associated syndrome and comparison with different patient cohorts [J].Clin Exp Rheumatol,2022, 40(3): 625-630.
46
Vulsteke JB, Satoh M, Malyavantham K, et al.Anti-OJ autoantibodies:Rare or Underdetected? [J].Autoimmun Rev, 2019, 18(7): 658-664.
47
Moll SA, Platenburg M, Platteel ACM, et al.Prevalence of novel myositis autoantibodies in a large cohort of patients with interstitial lung disease [J].J Clin Med, 2020, 9(9): 2944.
48
Wu S, Xiao X, Zhang Y, et al.Novel endotypes of antisynthetase syndrome identified independent of anti-aminoacyl transfer RNA synthetase antibody specificity that improve prognostic stratification[J].Ann Rheum Dis, 2024, 83(6): 775-786.
[1] 梁波, 张春雨, 郑永财, 徐冰, 蒋敏娜, 赵学刚, 刘晓敏. 结缔组织疾病相关间质性肺病肺部超声与疾病严重程度的相关性[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(06): 875-881.
[2] 韩晓, 汤凤莲, 张友文, 吕高超, 姜波, 王利江. 结缔组织相关性间质性肺病血清S1P 水平与疾病严重程度和免疫抑制治疗的关系[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(06): 869-874.
[3] 杨莎莎, 张毛为, 孙宜田, 刘亚南, 位娟, 魏建, 陈碧. 结缔组织疾病相关间质性肺病并发小气道功能障碍临床分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 738-743.
[4] 蔡欣诺, 邵思琪, 马华, 周冬梅, 潘彬, 殷松楼. 艾拉莫德通过抑制TNF-α减轻博来霉素诱导的小鼠间质性肺病[J/OL]. 中华肺部疾病杂志(电子版), 2022, 15(03): 331-334.
[5] 王亚飞, 吴振彪. 自身抗体在皮肌炎患者管理中的应用[J/OL]. 中华临床医师杂志(电子版), 2022, 16(08): 796-800.
阅读次数
全文


摘要