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中华临床医师杂志(电子版) ›› 2024, Vol. 18 ›› Issue (12) : 1146 -1149. doi: 10.3877/cma.j.issn.1674-0785.2024.12.011

综述

免疫检查点抑制剂治疗既往存在自身免疫性疾病的肿瘤患者:挑战与期待
樊勇1, 郝燕捷1, 赵娟1, 耿研1, 张卓莉1,()   
  1. 1. 100034 北京,北京大学第一医院风湿免疫科
  • 收稿日期:2024-12-09 出版日期:2024-12-15
  • 通信作者: 张卓莉
  • 基金资助:
    国家自然科学基金青年项目(编号82000060),北京大学临床医学+ X青年专项(中央高校基本科研业务费,编号PKU2023LCXQ005),北京大学第一医院科研种子基金(编号2020SF02)

Immune checkpoint inhibitors in advanced cancer patients with pre-existing autoimmune diseases: challenges and prospects

Yong Fan1, Yanjie Hao1, Juan Zhao1, Yan Geng1, Zhuoli Zhang1,()   

  1. 1. Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China
  • Received:2024-12-09 Published:2024-12-15
  • Corresponding author: Zhuoli Zhang
引用本文:

樊勇, 郝燕捷, 赵娟, 耿研, 张卓莉. 免疫检查点抑制剂治疗既往存在自身免疫性疾病的肿瘤患者:挑战与期待[J/OL]. 中华临床医师杂志(电子版), 2024, 18(12): 1146-1149.

Yong Fan, Yanjie Hao, Juan Zhao, Yan Geng, Zhuoli Zhang. Immune checkpoint inhibitors in advanced cancer patients with pre-existing autoimmune diseases: challenges and prospects[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(12): 1146-1149.

免疫检查点抑制剂在肿瘤治疗领域取得里程碑式突破,极大地改善了恶性肿瘤患者的整体预后。但由于其可能导致自身免疫性疾病的复发或恶化,因此几乎所有ICIs的临床试验均排除了合并AIDs的恶性肿瘤患者。针对这类特殊人群患者是否可以尝试ICIs治疗,治疗的风险及获益如何等问题,本文将系统性总结ICIs在既往存在AIDs的肿瘤患者中的应用现状、挑战及前景,以期为这类特殊人群使用ICIs治疗并取得良好疗效提供综合指导。

Immune checkpoint inhibitors (ICIs) have achieved a milestone breakthrough in the field of advanced cancer treatment, greatly improving the overall prognosis of these patients. However, due to their potential to lead to the recurrence or exacerbation of autoimmune diseases (AIDs), almost all clinical trials involving ICIs have excluded malignant tumor patients with concurrent AIDs. Can patients in this specific group attempt ICI treatment? What are the risks and benefits of this treatment? This article will systematically summarize the current application status, challenges, and prospects of ICIs in tumor patients with pre-existing AIDs, aiming to provide comprehensive guidance for the use of ICIs in this special population to achieve favourable therapeutic effects.

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