目的

探讨胃蛋白酶原测定检查在儿童幽门螺杆菌（Hp）相关性胃炎检测中的意义。

方法

选取2019年8月至2023年10月有消化道症状的患儿为研究对象，所有患儿均完成胃镜检查、胃黏膜组织活检、¹³C呼气试验及血清胃蛋白酶原测定检查。根据检查结果分为Hp病例组及健康对照组，分析PG筛查Hp相关胃炎的价值。

结果

与健康体检组比较，Hp相关胃炎患者的血清PGⅠ和PGⅡ水平均显著升高，PGⅠ/PGⅡ显著降低，差异具有统计学意义（P＜0.05），经多因素Logistic回归分析结果显示，仅有血清PGⅡ水平为儿童Hp相关胃炎的独立风险因素，差异有统计学意义，以约登指数最大时作为最佳诊断临界值，PGⅡ的最佳诊断临界值为11.25 μg/L。

结论

当儿童胃功能测定检查中PGⅡ为11.25 μg/L有助于诊断儿童Hp相关性胃炎诊断，应建议家长进一步进行胃镜等相关检查。

Objective

To explore the significance of serum pepsinogen in the detection of Helicobacter pylori （Hp）-associated gastritis in children.

Methods

Children with gastrointestinal symptoms were selected from August 2019 to October 2023. All children underwent gastroscopy， gastric mucosal tissue biopsy， ¹³C breath test， and serum pepsinogen determination. According to the examination results， they were divided into either an Hp infection group or a healthy control group to analyze the value of serum PG for detecting Hp-associated gastritis.

Results

Compared with the healthy control group， serum PG-I and PGII levels in Hp-related gastritis patients were significantly increased， and PG-I / PG-II ratio was significantly decreased （P＜0.05）. Multivariate Logistic regression analysis showed that only serum PG-II level was an independent risk factor for Hp-related gastritis in children. The best diagnostic critical value was 11.25 μg/L for PG-II when the Youden index was the largest.

Conclusion

Serum PG-II is helpful for the diagnosis of Hp-associated gastritis in children. When serum PG-II is＞11.25 μg/L， gastroscopy and other related examinations should be advised.