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中华临床医师杂志(电子版) ›› 2025, Vol. 19 ›› Issue (03) : 234 -239. doi: 10.3877/cma.j.issn.1674-0785.2025.03.011

综述

HBV 功能性治愈的联合策略研究进展
包萨础拉1, 温都苏1,()   
  1. 1. 137400 内蒙古兴安盟,内蒙古兴安盟人民医院消化内科
  • 收稿日期:2025-03-31 出版日期:2025-03-15
  • 通信作者: 温都苏

Research progress on combined strategies for functional cure of HBV

Sachula Bao1, Dusu Wen1,()   

  1. 1. Department of Gastroenterology,Xing'an League People's Hospital,Inner Mongolia,Ulanhot 137400,China
  • Received:2025-03-31 Published:2025-03-15
  • Corresponding author: Dusu Wen
引用本文:

包萨础拉, 温都苏. HBV 功能性治愈的联合策略研究进展[J/OL]. 中华临床医师杂志(电子版), 2025, 19(03): 234-239.

Sachula Bao, Dusu Wen. Research progress on combined strategies for functional cure of HBV[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2025, 19(03): 234-239.

慢性乙型肝炎病毒(HBV)感染是全球范围内的重要公共健康问题,严重影响患者的生活质量并增加肝硬化和肝细胞癌的风险。近年来,功能性治愈成为研究的热点,尤其是小干扰RNA(siRNA)技术和Toll 样受体8(TLR8)激动剂的结合应用。本文综述了HBV 功能性治愈领域的最新进展,重点分析了siRNA(如VIR-2218)与TLR8 激动剂之间的协同机制。通过对现有文献的深入探讨,本文概述了这两种治疗策略在HBV 清除中的潜在优势与前景,尤其是在增强免疫反应和促进病毒清除方面的相互作用,为后续临床研究提供了重要的理论依据。

Chronic hepatitis B virus (HBV) infection is a significant global public health issue,severely impacting patients' quality of life and increasing the risk of liver cirrhosis and hepatocellular carcinoma.In recent years,functional cure has emerged as a major research priority,particularly with the combined application of small interfering RNA (siRNA) technology and Toll-like receptor 8 (TLR8) agonists.This article reviews the latest advancements in the field of functional cure for HBV infection,with a focus on analyzing the synergistic mechanisms between siRNAs (e.g.,VIR-2218) and TLR8 agonists.Through an indepth examination of the existing literature,this paper outlines the potential advantages and prospects of these two therapeutic strategies in HBV clearance,especially their interplay in enhancing immune responses and promoting viral eradication,with an aim to provide an important theoretical foundation for subsequent clinical research.

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