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中华临床医师杂志(电子版) ›› 2025, Vol. 19 ›› Issue (03) : 229 -233. doi: 10.3877/cma.j.issn.1674-0785.2025.03.010

综述

S100B 蛋白在心血管疾病中的研究进展
王美琴1, 潘海涛1, 陈祥菲1, 吴婉1, 周昱和1,(), 王砚青1   
  1. 1. 210000 南京,中国人民解放军东部战区总医院全科医学科
  • 收稿日期:2025-02-26 出版日期:2025-03-15
  • 通信作者: 周昱和
  • 基金资助:
    中国人民解放军东部战区总医院院管课题(编号:2023LCYYXH009)

Progress in research of S100B protein in cardiovascular diseases

Meiqin Wang1, Haitao Pan1, Xiangfei Chen1, Wan Wu1, Yuhe Zhou1,(), Yanqing Wang1   

  1. 1. Department of General Practice,General Hospital of the Eastern Theater Command of the People's Liberation Army of China,Nanjing 210000,China
  • Received:2025-02-26 Published:2025-03-15
  • Corresponding author: Yuhe Zhou
引用本文:

王美琴, 潘海涛, 陈祥菲, 吴婉, 周昱和, 王砚青. S100B 蛋白在心血管疾病中的研究进展[J/OL]. 中华临床医师杂志(电子版), 2025, 19(03): 229-233.

Meiqin Wang, Haitao Pan, Xiangfei Chen, Wan Wu, Yuhe Zhou, Yanqing Wang. Progress in research of S100B protein in cardiovascular diseases[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2025, 19(03): 229-233.

S100B 是二价钙离子结合蛋白,主要由神经系统星形胶质细胞、施万细胞和少突胶质细胞中分泌,临床上多用于评估脑损伤及其程度。作为一种损伤相关的模式分子,S100B 在心肌细胞也可分泌,损伤心脏血管内皮、诱导心肌细胞凋亡、破坏心肌细胞中钙离子稳态、抑制心脏固有神经系统,导致心肌损伤与心室重塑,诱发心血管事件发生。本文综述了S100B 蛋白在心脏疾病中的研究进展,打开S100B 蛋白可能被视为心血管系统疾病诊断治疗靶点的视角。

S100B is a calcium binding protein,mainly secreted by astrocytes,Schwann cells,and oligodendrocytes in the nervous system.It is commonly used clinically to evaluate brain injury and its severity.As a damage-associated molecular pattern protein,S100B can also be secreted in cardiomyocytes,causing damage to the endothelium of cardiac blood vessels,inducing apoptosis of cardiomyocytes,disrupting calcium ion homeostasis in cardiomyocytes,inhibiting the intrinsic nervous system of the heart,leading to myocardial injury and ventricular remodeling,and inducing cardiovascular events.This article reviews the progress in the research of S100B protein in cardiovascular diseases,opening up the perspective that S100B protein may be considered as a diagnostic and therapeutic target for cardiovascular diseases.

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