切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2022, Vol. 16 ›› Issue (08) : 810 -814. doi: 10.3877/cma.j.issn.1674-0785.2022.08.020

综述

干燥综合征的靶向治疗进展
马豆豆1, 宁武1, 王宽婷1,()   
  1. 1. 100144 北京,北京大学首钢医院风湿免疫科
  • 收稿日期:2021-08-27 出版日期:2022-08-15
  • 通信作者: 王宽婷

Progress in targeted therapy of Sjögren's syndrome

Doudou Ma1, Wu Ning1, Kuanting Wang1,()   

  1. 1. Department of Rheumatology and Immunology, Peking University Shougang Hospital, Beijing 100144, China
  • Received:2021-08-27 Published:2022-08-15
  • Corresponding author: Kuanting Wang
引用本文:

马豆豆, 宁武, 王宽婷. 干燥综合征的靶向治疗进展[J]. 中华临床医师杂志(电子版), 2022, 16(08): 810-814.

Doudou Ma, Wu Ning, Kuanting Wang. Progress in targeted therapy of Sjögren's syndrome[J]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(08): 810-814.

干燥综合征(SS)是一种以外分泌腺受累为主,可累及全身系统的自身免疫性疾病。患者常因口干、眼干、疲劳、疼痛、脏器受累等,严重影响生活质量。近年来,随着人们对干燥综合征发病机制的深入认识,多种靶向药物正在研发中,有望用于治疗此类患者。

Sj?gren's syndrome (SS) is an autoimmune disease which is characterized by lymphocytic infiltration of exocrine glands and can involve many systems in the body. It affects the quality of life of patients seriously and has many manifestations including dryness of mouth and eyes, fatigue, painful, organ involvement, and so on. Thanks to a deeper understanding of SS pathogenesis in recent years, many new targeted drugs are expected to be promising therapeutic agents for SS.

表1 干燥综合征患者中尚无结果的临床试验
1
Qin B, Wang J, Yang Z, et al. Epidemiology of primary sjögren's syndrome: a systematic review and meta-analysis [J]. Ann Rheum Dis, 2015, 74(11): 1983-1989.
2
Miyamoto ST, Valim V, Fisher BA. Health-related quality of life and costs in Sjögren's syndrome [J]. Rheumatology (Oxford), 2019.
3
Mariette X, Seror R, Quartuccio L, et al. Efficacy and safety of belimumab in primary Sjögren's syndrome: results of the BELISS open-label phase Ⅱ study [J]. Ann Rheum Dis, 2015, 74(3): 526-531.
4
De Vita S, Quartuccio L, Seror R, et al. Efficacy and safety of belimumab given for 12 months in primary Sjögren's syndrome: the BELISS open-label phase II study [J]. Rheumatology (Oxford), 2015, 54(12): 2249-2256.
5
Dörner T, Posch MG, Li Y, et al. Treatment of primary Sjögren's syndrome with ianalumab (VAY736) targeting B cells by BAFF receptor blockade coupled with enhanced, antibody-dependent cellular cytotoxicity [J]. Ann Rheum Dis, 2019, 78(5): 641-647.
6
Bowman SJ, Fox R, Dörner T, et al. Safety and efficacy of subcutaneous ianalumab (VAY736) in patients with primary Sjögren's syndrome: a randomised, double-blind, placebo-controlled, phase 2b dose-finding trial [J]. Lancet, 2022, 399(10320): 161-171.
7
Alunno A, Carubbi F, Bistoni O, et al. Interleukin (IL)-17-producing pathogenic T lymphocytes co-express CD20 and are depleted by rituximab in primary Sjögren's syndrome: a pilot study [J]. Clin Exp Immunol, 2016, 184(3): 284-292.
8
Ciccia F, Guggino G, Rizzo A, et al. Rituximab modulates IL-17 expression in the salivary glands of patients with primary Sjögren's syndrome [J]. Rheumatology (Oxford), 2014, 53(7): 1313-1320.
9
Souza FB, Porfírio GJ, Andriolo BN, et al. Rituximab effectiveness and safety for treating primary Sjögren's syndrome (pSS): systematic review and meta-analysis [J]. PLoS One, 2016, 1(3): e0150749.
10
Pollard RP, Abdulahad WH, Vissink A, et al. Serum levels of BAFF, but not APRIL, are increased after rituximab treatment in patients with primary Sjogren's syndrome: data from a placebo-controlled clinical trial [J]. Ann Rheum Dis, 2013, 72(1): 146-148.
11
Chevalier K, Belkhir R, Seror R, et al. Efficacity of a sequential treatment by anti-CD 20 monoclonal antibody and belimumab in type Ⅱ cryoglobulinaemia associated with primary Sjögren syndrome refractory to rituximab alone [J]. Ann Rheum Dis, 2020, 79(9): 1257-1259.
12
Felten R, Devauchelle-Pensec V, Seror R, et al. Interleukin 6 receptor inhibition in primary Sjögren syndrome: a multicentre double-blind randomised placebo-controlled trial [J]. Ann Rheum Dis, 2020.
13
Steinfeld SD, Tant L, Burmester GR, et al. Epratuzumab (humanised anti-CD22 antibody) in primary Sjögren's syndrome: an open-label phase Ⅰ/Ⅱ study [J]. Arthritis Res Ther, 2006, 8(4): R129.
14
Nayar S, Campos J, Smith CG, et al. Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren's syndrome [J]. Ann Rheum Dis, 2019, 78(2): 249-260.
15
Juarez M, Diaz N, Johnston GI, et al. A phase 2 randomized, double-blind, placebo-controlled, proof-of-concept study of oral seletalisib in primary Sjögren's syndrome [J]. Rheumatology (Oxford), 2021, 60(3): 1364-1375.
16
Tsuboi H, Matsumoto I, Hagiwara S, et al. Effectiveness of abatacept for patients with Sjögren's syndrome associated with rheumatoid arthritis. An open label, multicenter, one-year, prospective study: ROSE (Rheumatoid Arthritis with Orencia Trial toward Sjögren's syndrome Endocrinopathy) trial [J]. Mod Rheumatol, 2016, 26(6): 891-899.
17
Machado AC, Dos Santos LC, Fidelix T, et al. Effectiveness and safety of abatacept for the treatment of patients with primary Sjögren's syndrome [J]. Clin Rheumatol, 2020, 39(1): 243-248.
18
Baer AN, Gottenberg JE, St Clair EW, et al. Efficacy and safety of abatacept in active primary Sjögren's syndrome: results of a phase Ⅲ, randomised, placebo-controlled trial [J]. Ann Rheum Dis, 2020, 80(3): 339-348.
19
Goules A, Tzioufas AG, Manousakis MN, et al. Elevated levels of soluble CD40 ligand (sCD40L) in serum of patients with systemic autoimmune diseases [J]. J Autoimmun, 2006, 26(3): 165-171.
20
Belkhir R, Gestermann N, Koutero M, et al. Upregulation of membrane-bound CD40L on CD4+ T cells in women with primary Sjögren's syndrome [J]. Scand J Immunol, 2014, 79(1): 37-42.
21
Retamozo S, Sisó-Almirall A, Flores-Chávez A, et al. An update of targeted therapeutic options for primary Sjögren syndrome: current status and future development [J]. Expert Opin Pharmacother, 2021, 22(17): 2359-2371.
22
Mariette X, Ravaud P, Steinfeld S, et al. Inefficacy of infliximab in primary Sjögren's syndrome: results of the randomized, controlled trial of remicade in primary sjögren's syndrome (TRIPSS) [J]. Arthritis Rheum, 2004, 50(4): 1270-1276.
23
Sankar V, Brennan MT, Kok MR, et al. Etanercept in Sjögren's syndrome: a twelve-week randomized, double-blind, placebo-controlled pilot clinical trial [J]. Arthritis Rheum, 2004, 50(7): 2240-2245.
24
Burge DJ, Eisenman J, Byrnes-Blake K, et al. Safety, pharmacokinetics, and pharmacodynamics of RSLV-132, an RNase-Fc fusion protein in systemic lupus erythematosus: a randomized, double-blind, placebo-controlled study [J]. Lupus, 2017, 26(8):825-834.
25
van den Hoogen LL, van Laar JM. Targeted therapies in systemic sclerosis, myositis, antiphospholipid syndrome, and Sjögren's syndrome [J]. Best Pract Res Clin Rheumatol, 2020, 34(1): 101485.
26
Price E, Bombardieri M, Kivitz A, et al. Safety and efficacy of filgotinib, lanraplenib, and tirabrutinib in Sjögren's syndrome: randomised, phase 2, double-blind, placebo-controlled study [J]. Rheumatology (Oxford), 2022.
27
Miao M, Hao Z, Guo Y, et al. Short-term and low-dose IL-2 therapy restores the Th17/Treg balance in the peripheral blood of patients with primary Sjögren's syndrome [J]. Ann Rheum Dis, 2018, 77(12): 1838-1840.
28
Bikker A, van Woerkom JM, Kruize AA, et al. Increased expression of interleukin-7 in labial salivary glands of patients with primary Sjögren's syndrome correlates with increased inflammation [J]. Arthritis Rheum, 2010, 62(4): 969-977.
29
Bikker A, Kruize AA, Wenting M, et al. Increased interleukin (IL)-7Rα expression in salivary glands of patients with primary Sjogren's syndrome is restricted to T cells and correlates with IL-7 expression, lymphocyte numbers and activity [J]. Ann Rheum Dis, 2012, 71(6): 1027-1033.
30
Zhou J, Yu Q. Anti-IL-7 receptor-α treatment ameliorates newly established Sjögren's-like exocrinopathy in non-obese diabetic mice [J]. Biochim Biophys Acta Mol Basis Dis, 2018, 1864(7): 2438-2447.
31
Rathinam VA, Fitzgerald KA. Inflammasome complexes: emerging mechanisms and effector functions [J]. Cell, 2016, 165(4): 792-800.
32
Khalafalla MG, Woods LT, Camden JM, et al. P2X7 receptor antagonism prevents IL-1β release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy [J]. J Biol Chem, 2017, 292(40): 16626-16637.
33
Vijmasi T, Chen FY, Chen YT, et al. Topical administration of interleukin-1 receptor antagonist as a therapy for aqueous-deficient dry eye in autoimmune disease [J]. Mol Vis, 2013, 19: 1957-1965.
34
Norheim KB, Harboe E, Gøransson LG, et al. Interleukin-1 inhibition and fatigue in primary Sjögren's syndrome-a double blind, randomised clinical trial [J]. PLoS One, 2012, 7(1): e30123.
35
Klinngam W, Janga SR, Lee C, et al. Inhibition of cathepsin S reduces lacrimal gland inflammation and increases tear flow in a mouse model of Sjögren's syndrome [J]. Sci Rep, 2019, 9(1): 9559.
36
Hargreaves P, Daoudlarian D, Theron M, et al. Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome [J]. Arthritis Res Ther, 2019, 21(1): 175.
[1] 蒋佳纯, 王晓冰, 陈培荣, 许世豪. 血清学指标联合常规超声及超声造影评分诊断原发性干燥综合征的临床价值[J]. 中华医学超声杂志(电子版), 2023, 20(06): 622-630.
[2] 王璐, 樊杨. 子宫内膜癌相关生物标志物研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 511-516.
[3] 林昌盛, 战军, 肖雪. 上皮性卵巢癌患者诊疗中基因检测及分子靶向药物治疗[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 505-510.
[4] 马敏榕, 李聪, 周勤. 宫颈癌治疗研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 497-504.
[5] 娄丽丽, 刘瀚旻. 儿童哮喘易感基因及表观遗传学研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(03): 249-255.
[6] 闫甲, 刘双池, 王政宇. 胆囊癌肿瘤标志物的研究和应用进展[J]. 中华普通外科学文献(电子版), 2023, 17(05): 391-394.
[7] 徐瑜杰, 赵国栋. 晚期胃癌治疗方法的研究进展和挑战[J]. 中华普外科手术学杂志(电子版), 2023, 17(04): 451-455.
[8] 南方护骨联盟前列腺癌骨转移专家组. 前列腺癌骨转移诊疗专家共识(2023版)[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(03): 201-208.
[9] 邵浩仁, 郭佳. 铁死亡的分子机制及其在前列腺癌治疗中的研究进展[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(03): 294-298.
[10] 王昆, 潘迪, 王庆, 江克华, 孙发. 机器人手术治疗膀胱副神经节瘤一例报告[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(03): 291-292.
[11] 周硕明, 甘卫东. 2022版欧洲泌尿外科学会肾细胞癌诊疗指南更新要点解读[J]. 中华腔镜泌尿外科杂志(电子版), 2023, 17(02): 100-104.
[12] 吴晨瑞, 廖锐, 贺强, 潘龙, 黄平, 曹洪祥, 赵益, 王永琛, 黄俊杰, 孙睿锐. MDT模式下肝动脉灌注化疗联合免疫靶向治疗肝细胞癌多处转移一例[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 713-716.
[13] 魏小勇. 原发性肝癌转化治疗焦点问题探讨[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 602-607.
[14] 吴寅, 陈智琴, 高勇, 权明. Her-2阳性结直肠癌的诊治进展[J]. 中华结直肠疾病电子杂志, 2023, 12(05): 420-425.
[15] 郝然, 魏姗珊, 吴倩如, 李学民, 翟长斌. 干燥综合征血清微量元素变化及其与疾病严重程度的相关性研究[J]. 中华眼科医学杂志(电子版), 2023, 13(04): 215-220.
阅读次数
全文


摘要