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中华临床医师杂志(电子版) ›› 2018, Vol. 12 ›› Issue (01) : 53 -56. doi: 10.3877/cma.j.issn.1674-0785.2018.01.010

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综述

慢性肾功能衰竭血液透析状态和恶性肿瘤的相互关系研究进展
李思倩1, 王颖轶2, 李明喜1,()   
  1. 1. 100730 北京 中国医学科学院北京协和医院肾内科
    2. 100730 北京 中国医学科学院北京协和医院肿瘤内科
  • 收稿日期:2017-06-18 出版日期:2018-01-01
  • 通信作者: 李明喜

Relationship between hemodialysis for chronic renal failure and malignancy

Siqian Li1, Yingyi Wang2, Mingxi Li1,()   

  1. 1. Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
    2. Oncological Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
  • Received:2017-06-18 Published:2018-01-01
  • Corresponding author: Mingxi Li
  • About author:
    Corresponding author: Li Mingxi, Email:
引用本文:

李思倩, 王颖轶, 李明喜. 慢性肾功能衰竭血液透析状态和恶性肿瘤的相互关系研究进展[J]. 中华临床医师杂志(电子版), 2018, 12(01): 53-56.

Siqian Li, Yingyi Wang, Mingxi Li. Relationship between hemodialysis for chronic renal failure and malignancy[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(01): 53-56.

随着血液透析技术的不断进步,终末期肾病的患者大多可以得到长期规律的血液透析治疗。由于氧化应激、免疫功能失调、病毒感染、透析前服用细胞毒性药物、特定肾病如获得性多囊肾、营养不良、DNA修复机制的改变等因素,血液透析合并恶性肿瘤的患者也越来越多。同时,癌症可以继发肾疾病,继而发展为慢性肾功能衰竭。慢性肾功能衰竭血液透析状态和恶性肿瘤可谓相互影响,互为危险因素。因此,肿瘤科专家和肾病专家有必要共同关注合并这两类疾病患者的治疗和生存预后等疾病管理策略。

With the progress of the hemodialysis technology, most of the patients with end-stage renal disease can receive long-term regular hemodialysis treatment. The number of patients receiving hemodialysis who develop malignancy is getting increasingly large, because of oxidative stress, the interference of the immune system, virus infection, cytotoxic agents, certain kidney diseases such as acquired polycystic kidney disease, malnutrition, and changes of the DNA repair system. On the other hand, kidney diseases and even chronic renal failure can be secondary to cancer. Thus, hemodialysis for chronic renal failure can be a risk factor for malignancy, and vice versa. Therefore, it is necessary for oncologists and nephrologists to share their experience in treatment and prognostic evaluation of these patients.

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