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中华临床医师杂志(电子版) ›› 2018, Vol. 12 ›› Issue (01) : 53 -56. doi: 10.3877/cma.j.issn.1674-0785.2018.01.010

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综述

慢性肾功能衰竭血液透析状态和恶性肿瘤的相互关系研究进展
李思倩1, 王颖轶2, 李明喜1,()   
  1. 1. 100730 北京 中国医学科学院北京协和医院肾内科
    2. 100730 北京 中国医学科学院北京协和医院肿瘤内科
  • 收稿日期:2017-06-18 出版日期:2018-01-01
  • 通信作者: 李明喜

Relationship between hemodialysis for chronic renal failure and malignancy

Siqian Li1, Yingyi Wang2, Mingxi Li1,()   

  1. 1. Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
    2. Oncological Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
  • Received:2017-06-18 Published:2018-01-01
  • Corresponding author: Mingxi Li
  • About author:
    Corresponding author: Li Mingxi, Email:
引用本文:

李思倩, 王颖轶, 李明喜. 慢性肾功能衰竭血液透析状态和恶性肿瘤的相互关系研究进展[J/OL]. 中华临床医师杂志(电子版), 2018, 12(01): 53-56.

Siqian Li, Yingyi Wang, Mingxi Li. Relationship between hemodialysis for chronic renal failure and malignancy[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(01): 53-56.

随着血液透析技术的不断进步,终末期肾病的患者大多可以得到长期规律的血液透析治疗。由于氧化应激、免疫功能失调、病毒感染、透析前服用细胞毒性药物、特定肾病如获得性多囊肾、营养不良、DNA修复机制的改变等因素,血液透析合并恶性肿瘤的患者也越来越多。同时,癌症可以继发肾疾病,继而发展为慢性肾功能衰竭。慢性肾功能衰竭血液透析状态和恶性肿瘤可谓相互影响,互为危险因素。因此,肿瘤科专家和肾病专家有必要共同关注合并这两类疾病患者的治疗和生存预后等疾病管理策略。

With the progress of the hemodialysis technology, most of the patients with end-stage renal disease can receive long-term regular hemodialysis treatment. The number of patients receiving hemodialysis who develop malignancy is getting increasingly large, because of oxidative stress, the interference of the immune system, virus infection, cytotoxic agents, certain kidney diseases such as acquired polycystic kidney disease, malnutrition, and changes of the DNA repair system. On the other hand, kidney diseases and even chronic renal failure can be secondary to cancer. Thus, hemodialysis for chronic renal failure can be a risk factor for malignancy, and vice versa. Therefore, it is necessary for oncologists and nephrologists to share their experience in treatment and prognostic evaluation of these patients.

1
Uchida K, Shoda J, Sugahara S, et al. Comparison and survival of patients receiving hemodialysis and peritoneal dialysis in a single center [J]. Adv Perit Dial, 2007, 23: 144-149.
2
Eneman JD, Philips GK. Cancer management in patients with end-stage renal disease [J]. Oncology (Williston Park), 2005, 19(9): 1199-1212.
3
Capusa C, Stoian I, Rus E, et al. Does dialysis modality influence the oxidative stress of uremic patients? [J]. Kidney Blood Press Res, 2012, 35(4): 220-225.
4
Popolo A, Autore G, Pinto A, et al. Oxidative stress in patients with cardiovascular disease and chronic renal failure [J]. Free Radic Res, 2013, 47(5): 346-356.
5
Yavuz O, Bicik Z, Cinar Y, et al. The effect of different dialysis membranes on oxidative stress and selenium status [J]. Clin Chim Acta, 2004, 346(2): 153-160.
6
Hauser AB, Stinghen AE, Kato S, et al. Characteristics and causes of immune dysfunction related to uremia and dialysis [J]. Perit Dial Int, 2008, 28(3): 183-187.
7
Autore G, Marzocco S, Sorrentino R, et al. In vitro and in vivo TNFalpha synthesis modulation by methylguanidine, an uremic catabolyte [J]. Life Sci, 1999, 65(11): 121-127.
8
Ridão Curty NF, da Silva Martins LF, Sanches Ito CA, et al. Morbimortality study of infection in patients undergoing different types of dialysis in a renal replacement therapy center [J]. Braz J Infect Dis, 2014, 18(3): 281-286.
9
Hekmat R, Gholami F, Ahmadnia H, et al. Serum human T-lymphotropic virus 1 proviral load in patients on hemodialysis [J]. Iran J Kidney Dis, 2013, 7(2): 124-128.
10
Holley JL. Screening, diagnosis, and treatment of cancer in long-term dialysis patients [J]. Clin J Am Soc Nephrol, 2007, 2(3): 604-610.
11
Yamamoto T, Nakajima Y, Yamamoto M, et al. Epstein-Barr virus activity in patients on chronic hemodialysis [J]. Nephron, 1995, 70(4): 449-454.
12
Fissell RB, Bragg-Gresham JL, Woods JD, et al. Patterns of hepatitis C prevalence and seroconversion in hemodialysis units from three continents: the DOPPS [J]. Kidney Int, 2004, 65(6): 2335-2342.
13
Johnson DW, Dent H, Yao Q, et al. Frequencies of hepatitis B and C infections among haemodialysis and peritoneal dialysis patients in Asia-Pacific countries: analysis of registry data [J]. Nephrol Dial Transplant, 2009, 24(5): 1598-1603.
14
Bugelski PJ, Volk A, Walker MR, et al. Critical review of preclinical approaches to evaluate the potential of immunosuppressive drugs to influence human neoplasia [J]. Int J Toxicol, 2010, 29(5): 435-466.
15
Radis CD, Kahl LE, Baker GL, et al. Effects of cyclophosphamide on the development of malignancy and on long-term survival of patients with rheumatoid arthritis. A 20-year followup study [J]. Arthritis Rheum,1995, 38(8): 1120-1127.
16
Vial T, Descotes J. Immunosuppressive drugs and cancer [J]. Toxicology, 2003, 185(3): 229-240.
17
Nagy A, Walter E, Zubakov D, et al. High risk of development of renal cell tumor in end-stage kidney disease: the role of microenvironment [J]. Tumour Biol, 2016, 37(7): 9511-9519.
18
Bonsib SM. Renal cystic diseases and renal neoplasms: a mini-review [J]. Clin J Am Soc Nephrol, 2009, 4(12): 1998-2007.
19
Denton MD, Magee CC, Ovuworie C, et al. Prevalence of renal cell carcinoma in patients with ESRD pre-transplantation: a pathologic analysis [J]. Kidney Int, 2002, 61(6): 2201-2209.
20
Kalantar-Zadeh K, Kopple JD. Relative contributions of nutrition and inflammation to clinical outcome in dialysis patients [J]. Am J Kidney Dis, 2001, 38(6): 1343-1350.
21
Blaszczyk U, Duda-Chodak A. Magnesium: its role in nutrition and carcinogenesis [J]. Rocz Panstw Zakl Hig, 2013, 64(3): 165-171.
22
Duthie SJ. Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesis [J]. J Inherit Metab Dis, 2011, 34(1): 101-109.
23
Mandayam S, Shahinian VB. Are chronic dialysis patients at increased risk for cancer? [J]. J Nephrol, 2008, 21(2): 166-174.
24
Maisonneuve P, Agodoa L, Gellert R, et al. Cancer in patients on dialysis for end-stage renal disease: an international collaborative study [J]. Lancet, 1999, 354(9173): 93-99.
25
Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers [J]. Nature, 1998, 396(6712): 643-649.
26
Rao M, Li L, Demello C, et al. Mitochondrial DNA injury and mortality in hemodialysis patients [J]. J Am Soc Nephrol, 2009, 20(1): 189-196.
27
Sebekova K, Wagner Z, Schupp N, et al. Genomic damage and malignancy in end-stage renal failure: do advanced glycation end products contribute? [J]. Kidney Blood Press Res, 2007, 30(1): 56-66.
28
Lin MY, Kuo MC, Hung CC, et al. Association of dialysis with the risks of cancers [J]. PloS One, 2015, 10(4): e0122856.
29
Herman M, Ori Y, Chagnac A, et al. Spontaneous DNA repair increases during hemodialysis [J]. Nephron Clin Pract, 2008, 108(3): 188-193.
30
Ronco PM. Paraneoplastic glomerulopathies: new insights into an old entity [J]. Kidney Int, 1999, 56(1): 355-377.
31
Cambier JF, Ronco P. Onco-nephrology: glomerular diseases with cancer [J]. Clin J Am Soc Nephrol, 2012, 7(10): 1701-1712.
32
Magyarlaki T, Kiss B, Buzogany I, et al. Renal cell carcinoma and paraneoplastic IgA nephropathy [J]. Nephron, 1999, 82(2): 127-130.
33
Tatsis E, Reinhold-Keller E, Steindorf K, et al. Wegener′s granulomatosis associated with renal cell carcinoma [J]. Arthritis Rheum, 1999, 42(4): 751-756.
34
Bacchetta J, Juillard L, Cochat P, et al. Paraneoplastic glomerular diseases and malignancies [J]. Crit Rev Oncol Hematol, 2009, 70(1): 39-58.
35
Audard V, Larousserie F, Grimbert P, et al. Minimal change nephrotic syndrome and classical Hodgkin′s lymphoma: report of 21 cases and review of the literature [J]. Kidney Int, 2006, 69(12): 2251-2260.
36
Audard V, Zhang SY, Copie-Bergman C, et al. Occurrence of minimal change nephrotic syndrome in classical Hodgkin lymphoma is closely related to the induction of c-mip in Hodgkin-Reed Sternberg cells and podocytes [J]. Blood, 2010, 115(18): 756-3762.
37
Heher EC, Rennke HG, Laubach JP, et al. Kidney disease and multiple myeloma [J]. Clin J Am Soc Nephrol, 2013, 8(11): 2007-2017.
38
Janus N, Launay-Vacher V, Thyss A, et al. Management of anticancer treatment in patients under chronic dialysis: results of the multicentric CANDY (CANcer and DialYsis) study [J]. Ann Oncol, 2013, 24(2): 501-507.
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