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中华临床医师杂志(电子版) ›› 2018, Vol. 12 ›› Issue (01) : 57 -61. doi: 10.3877/cma.j.issn.1674-0785.2018.01.011

所属专题: 急危重症 文献

综述

参与脓毒症调控的信号通路的研究进展
周佳伟1, 姜琴1, 侯林义1, 付玉梅1, 张文凯1,()   
  1. 1. 030001 太原,山西医科大学第二医院重症医学科
  • 收稿日期:2017-07-30 出版日期:2018-01-01
  • 通信作者: 张文凯
  • 基金资助:
    山西省归国留学项目(2011-105); 山西省太原市科技项目(12016905)

Signaling pathways involved in inflammatory response in sepsis

Jiawei Zhou1, Qin Jiang1, Linyi Hou1, Yumei Fu1, Wenkai Zhang1,()   

  1. 1. Department of Intensive Care Unit, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2017-07-30 Published:2018-01-01
  • Corresponding author: Wenkai Zhang
  • About author:
    Corresponding author: Zhang Wenkai, Email:
引用本文:

周佳伟, 姜琴, 侯林义, 付玉梅, 张文凯. 参与脓毒症调控的信号通路的研究进展[J/OL]. 中华临床医师杂志(电子版), 2018, 12(01): 57-61.

Jiawei Zhou, Qin Jiang, Linyi Hou, Yumei Fu, Wenkai Zhang. Signaling pathways involved in inflammatory response in sepsis[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(01): 57-61.

脓毒症是外科重症监护病房(ICU)患者死亡的原因之一,其因高患病率、高死亡率、高费用,而且缺乏有效的针对性治疗策略,成为威胁人类健康的重要疾病之一。脓毒症的发生发展与促炎和抗炎反应失衡密切相关,但是具体调控机制尚不清楚。因此全面了解脓毒症患者炎症反应的发生机制,参与炎症反应细胞的各种重要的信号转导通路[核因子-κB通路、丝裂原激活的蛋白激酶(MAPK)通路、酪氨酸激酶-信号转导和转录激活子(JAK-STAT)通路、磷脂酰肌醇3激酶/丝苏氨酸蛋白激酶(PI3K/AKT)通路、糖原合成酶-3(GSK-3)通路、胆碱能抗炎通路(CAP)]和细胞因子的表达,对于找到有效特异性高的脓毒症预防和治疗措施具有重大的意义。本文就目前参与脓毒症反应的各种信号通路以及各信号通路之间交互作用进行综述。

Sepsis is a common cause of death of patients in surgical intensive care unit (ICU). Because of its high prevalence, high mortality, and lack of effective therapy, sepsis has become one of important diseases that threaten human health. The development of sepsis is closely related to the imbalance of pro-inflammatory and anti-inflammatory responses. However, the underlying regulatory mechanism is still largely unclear. Therefore, a comprehensive understanding of the important signaling transduction pathways involved in inflammatory response in patients with sepsis, including nuclear transcription factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), Janus kinase-signal transducer and activators of transcription (JAK-STAT), phosphatidylinositol 3 kinase/serine- threonine protein kinase (PI3K/AKT), glycogen synthase kinase-3 (GSK-3), the cholinergic anti-inflammatory pathway (CAP), and the expression of cytokines, is of great significance for finding highly effective preventive and therapeutic strategies for sepsis. In this article, we summarize the signaling pathways involved in inflammatory response in sepsis and the interactions of these signaling pathways.

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