切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2018, Vol. 12 ›› Issue (03) : 173 -176. doi: 10.3877/cma.j.issn.1674-0785.2018.03.011

所属专题: 文献

综述

Claudin-18在胃癌中的临床表达关系与治疗
左忠林1, 陈鹏1, 陈小龙1, 夏冬1,()   
  1. 1. 646000 四川泸州,西南医科大学附属第一医院胃肠外科
  • 收稿日期:2017-09-08 出版日期:2018-02-01
  • 通信作者: 夏冬

Potential role of Claudin-18 in treatment of gastric cancer

Zhonglin Zuo1, Peng Chen1, Xiaolong Chen1, Dong Xia1,()   

  1. 1. Department of Gastrointestinal Surgery, The First Affiliated Hospital of Southwestern Medical University, Luzhou 646000, China
  • Received:2017-09-08 Published:2018-02-01
  • Corresponding author: Dong Xia
  • About author:
    Corresponding author: Xia Dong, Email:
引用本文:

左忠林, 陈鹏, 陈小龙, 夏冬. Claudin-18在胃癌中的临床表达关系与治疗[J]. 中华临床医师杂志(电子版), 2018, 12(03): 173-176.

Zhonglin Zuo, Peng Chen, Xiaolong Chen, Dong Xia. Potential role of Claudin-18 in treatment of gastric cancer[J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(03): 173-176.

胃癌是目前全世界发病率和病死率较高的癌症之一。近几年,免疫治疗和靶向治疗的发展彻底改变了癌症的治疗模式,找到一个在肿瘤中特异性表达的蛋白质成为药物靶点是该领域主要的研究方向。Claduin-18表达于胃黏膜上皮,参与构成上皮屏障功能,在胃癌中具有独特的表达模式,是靶向治疗中的一个良好靶蛋白,因此Claudin-18具有广阔的研究前景。本篇综述将介绍Claduin-18蛋白的功能、在胃癌中表达模式和治疗方面研究的最新进展。

Gastric cancer is a malignancy with high morbidity and mortality. In recent years, the development of targeted therapy and immunotherapy has revolutionized the therapeutic model for various cancers. Identifying proteins exclusively expressed in tumors is a research direction in this field. Claudin-18 is expressed in gastric mucosa, participates in the barrier function, and has unique expression patterns in gastric cancer. Therefore, Claudin-18 is a promising target for the treatment of gastric cancer. This paper will review the function and expression pattern of Claudin-18 as well as its potential role in the treatment of gastric cancer.

[1]
Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012 [J]. CA Cancer J Clin, 2015, 65(2): 87-108.
[2]
Wen WM, PhD AAAM. Novel agents on the horizon for cancer therapy [J]. Ca Cancer J Clin, 2009, 59(2): 111-137.
[3]
Mitic LL, Van Itallie CM, Anderson JM. Molecular physiology and pathophysiology of tight junctions I. Tight junction structure and function: lessons from mutant animals and proteins [J]. Am J Physiol Gastrointest Liver Physiol, 2000, 279(2): G250-G254.
[4]
Tsukita S, Furuse M. Pores in the wall: claudins constitute tight junction strands containing aqueous pores [J]. J Cell Biol, 2000, 149(1): 13-16.
[5]
Hayashi D, Tamura A, Tanaka H, et al. Deficiency of claudin-18 causes paracellular h+ leakage, up-regulation of interleukin-1β, and atrophic gastritis in mice [J]. Gastroenterology, 2012, 142(2): 292-304.
[6]
Lameris AL, Huybers S, Kaukinen K, et al. Expression profiling of claudins in the human gastrointestinal tract in health and during inflammatory bowel disease [J]. Scand J Gastroentero, 2013, 48(1): 58-69.
[7]
Pope JL, Bhat AA, Sharma A, et al. Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling [J]. Gut, 2014, 63(4): 622-634.
[8]
Huang GW, Ding X, Chen SL, et al. Expression of claudin 10 protein in hepatocellular carcinoma: impact on survival [J]. J Cancer Res Clin, 2011, 137(8): 1213-1218.
[9]
Matsuda Y, Semba S, Ueda J, et al. Gastric and intestinal claudin expression at the invasive front of gastric carcinoma [J]. Cancer Sci, 2007, 98(7): 1014-1019.
[10]
Singh P, Toom S, Huang Y. Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer [J]. J Hematol Oncol, 2017, 10(1): 105.
[11]
Shinozaki A, Shibahara J, Noda N, et al. Claudin-18 in biliary neoplasms. Its significance in the classification of intrahepatic cholangiocarcinoma [J]. Virchows Arch, 2011, 459(1): 73-80.
[12]
Micke P, Mattsson JSM, Edlund K, et al. Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer [J]. Int J Cancer, 2014, 135(9): 2206-2214.
[13]
Woll S, Schlitter AM, Dhaene K, et al. Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms [J]. Int J Cancer, 2014, 134(3): 731-739.
[14]
Matsuda M, Sentani K, Noguchi T, et al. Immunohistochemical analysis of colorectal cancer with gastric phenotype: Claudin-18 is associated with poor prognosis [J]. Pathol Int, 2010, 60(10): 673-680.
[15]
Sahin U, Koslowski M, Dhaene K, et al. Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development [J]. Clin Cancer Res, 2008, 14(23): 7624-7634.
[16]
Yao F, Kausalya JP, Sia YY, et al. Recurrent fusion genes in gastric cancer: Claudin18-ARH-GAP26 induces loss of epithelial integrity [J]. Cell Rep, 2015, 12(2): 272-285.
[17]
Jun KH, Kim JH, Jung JH, et al. Expression of claudin-7 and loss of claudin-18 correlate with poor prognosis in gastric cancer [J]. Int J Surg, 2014, 12(2): 156-162.
[18]
Oshima T, Shan J, Okugawa T, et al. Down-regulation of claudin-18 is associated with the proliferative and invasive potential of gastric cancer at the invasive front [J]. PloS One, 2013, 8(9): e74757.
[19]
王行富,张声,郑珂, 等. Claudin18表达在胃癌进展中的意义 [J]. 中国肿瘤临床, 2011, 38(11): 642-646.
[20]
杨士贤,吴铁镛,刘晓刚. 胃腺癌组织中紧密连接蛋白7和紧密连接蛋白18及E钙黏素的表达及其意义 [J]. 中国全科医学, 2013, 16(3): 267-270.
[21]
Sentani K, Oue N, Tashiro T, et al. Immunohistochemical staining of Reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma [J]. Am J Surg Pathol, 2008, 32(8): 1182-1189.
[22]
宋洁,郭瑞芳,苏日拉, 等. TFF2、Claudin18、MUC5AC蛋白在胃黏膜病变过程中的表达变化及其临床意义 [J]. 胃肠病学, 2015, 20(7): 394-397.
[23]
Jalava P, Kuopio T, Juntti-Patinen L, et al. Ki67 immunohistochemistry: a valuable marker in prognostication but with a risk of misclassification: proliferation subgroups formed based on Ki67 immunoreactivity and standardized mitotic index [J]. Histopathology, 2006, 48(6): 674-682.
[24]
Taylor JM, Macklem MM, Parsons JT. Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho [J]. J Cell Sci, 1999, 112(Pt2): 231-242.
[25]
Zhang SJ, Feng JF, Wang L, et al. miR-1303 targets claudin-18 gene to modulate proliferation and invasion of gastric cancer cells [J]. Dig Dis Sci, 2014, 59(8): 1754-1763.
[26]
Gurtan AM, Sharp PA. The role of miRNAs in regulating gene expression networks [J]. J Mol Biol, 2013, 425(19): 3582-3600.
[27]
Li K, Li J. Current molecular targeted therapy in advanced gastric cancer: a comprehensive review of therapeutic mechanism, clinical trials, and practical application [J]. Gastroenterol Res Pract, 2016, 2016: 4105615.
[28]
吕元皓,季鸣,陈晓光. 胃癌免疫治疗研究进展 [J]. 中国生化药物杂志, 2016, 36(11): 197-199.
[29]
Al-Batran S, Schuler MH, Zvirbule Z, et al. FAST: An international, multicenter, randomized, phase II trial of epirubicin, oxaliplatin, and capecitabine (EOX) with or without IMAB362, a first-in-class anti-Claudin18.2 antibody, as first-line therapy in patients with advanced Claudin18.2+ gastric and gastroesophageal junction (GEJ) adenocarcinoma [J]. J Clin Oncol, 2016, 34(18suppl): A4001.
[30]
Matsusaka K, Ushiku T, Urabe M, et al. Coupling CDH17 and Claudin18 markers for comprehensive membrane-targeted detection of human gastric cancer [J]. Oncotarget, 2016, 7(39): 64168-64181.
[1] 孙帼, 谢迎东, 徐超丽, 杨斌. 超声联合临床特征的列线图模型预测甲状腺乳头状癌淋巴结转移的价值[J]. 中华医学超声杂志(电子版), 2023, 20(07): 734-742.
[2] 康夏, 田浩, 钱进, 高源, 缪洪明, 齐晓伟. 骨织素抑制破骨细胞分化改善肿瘤骨转移中骨溶解的机制研究[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 329-339.
[3] 江艺, 张小进, 沈佳佳. 胆囊癌伴肝多发转移手术治疗(腹腔镜下胆囊癌切除+淋巴结清扫+肝Ⅴ、Ⅵ、Ⅶ段切除)[J]. 中华普通外科学文献(电子版), 2023, 17(06): 412-412.
[4] 唐旭, 韩冰, 刘威, 陈茹星. 结直肠癌根治术后隐匿性肝转移危险因素分析及预测模型构建[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 16-20.
[5] 晏晴艳, 雍晓梅, 罗洪, 杜敏. 成都地区老年转移性乳腺癌的预后及生存因素研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 636-638.
[6] 徐成, 王璐璐, 王少华. 洗脱液甲状腺球蛋白在甲状腺乳头状癌转移淋巴结中的应用[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 701-704.
[7] 魏小勇. 原发性肝癌转化治疗焦点问题探讨[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 602-607.
[8] 吴晨瑞, 廖锐, 贺强, 潘龙, 黄平, 曹洪祥, 赵益, 王永琛, 黄俊杰, 孙睿锐. MDT模式下肝动脉灌注化疗联合免疫靶向治疗肝细胞癌多处转移一例[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 713-716.
[9] 肖体先, 刘骞, 宋京海. 乳房外Paget病脾转移一例报告[J]. 中华肝脏外科手术学电子杂志, 2023, 12(06): 717-719.
[10] 韩晓娟, 徐佳倩, 朱玉兰, 王莹, 李源, 冯珺, 邵东. HHLA2过表达胃癌细胞株构建及细胞功能的初步研究[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 373-377.
[11] 钟广俊, 刘春华, 朱万森, 徐晓雷, 王兆军. MRI联合不同扫描序列在胃癌术前分期诊断及化疗效果和预后的评估[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 378-382.
[12] 王小红, 钱晶, 翁文俊, 周国雄, 朱顺星, 祁小鸣, 刘春, 王萍, 沈伟, 程睿智, 秦璟灏. 巯基丙酮酸硫基转移酶调控核因子κB信号介导自噬对重症急性胰腺炎大鼠的影响及机制[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 422-426.
[13] 孙秀艳, 徐庆蕾, 马鹏涛, 胡志元, 郭传真, 祝成红. 腹腔镜胃癌根治术中患者体温变化与压力性损伤及受压部位微环境的相关性分析[J]. 中华消化病与影像杂志(电子版), 2023, 13(06): 480-484.
[14] 董青, 丁飞, 郭浩, 李峰. Nesfatin-1/NUCB2在幽门螺杆菌感染相关早期胃癌患者中的表达及临床意义[J]. 中华临床医师杂志(电子版), 2023, 17(07): 783-789.
[15] 孔凡彪, 杨建荣. 肝脏基础疾病与结直肠癌肝转移之间关系的研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(07): 818-822.
阅读次数
全文


摘要