切换至 "中华医学电子期刊资源库"

中华临床医师杂志(电子版) ›› 2023, Vol. 17 ›› Issue (07) : 818 -822. doi: 10.3877/cma.j.issn.1674-0785.2023.07.010

综述

肝脏基础疾病与结直肠癌肝转移之间关系的研究进展
孔凡彪, 杨建荣()   
  1. 530023 南宁,广西壮族自治区人民医院结直肠肛门外科 广西医学科学院微创技术与应用研究所
    530021 南宁,广西壮族自治区人民医院肝胆胰脾外科 广西医学科学院微创技术与应用研究所
  • 收稿日期:2022-08-15 出版日期:2023-07-15
  • 通信作者: 杨建荣
  • 基金资助:
    国家自然科学基金(81660416,82260468); 广西科技重大专项(AA22096018); 广西卫健委自筹经费科研课题(Z20180739,Z20221111); 广西壮族自治区人民医院青年基金(QN2018-22); 广西自然科学基金项目(2023GXNSFAA026341)

Progress in understanding of relationship between underlying liver diseases and liver metastasis of colorectal cancer

Fanbiao Kong, Jianrong Yang()   

  1. Department of Colorectal and Anal Surgery, People's Hospital of Guangxi Zhuang Autonomous Region & Institute of Minimally Invasive Technology and Applications Guangxi Academy of Medical Sciences, Nanning 530023, China
    Department of Hepatobiliary, Pancreatic and Splenic Surgery, People's Hospital of Guangxi Zhuang Autonomous Region & Institute of Minimally Invasive Technology and Applications, Guangxi Academy of Medical Sciences, Nanning 530021, China
  • Received:2022-08-15 Published:2023-07-15
  • Corresponding author: Jianrong Yang
引用本文:

孔凡彪, 杨建荣. 肝脏基础疾病与结直肠癌肝转移之间关系的研究进展[J/OL]. 中华临床医师杂志(电子版), 2023, 17(07): 818-822.

Fanbiao Kong, Jianrong Yang. Progress in understanding of relationship between underlying liver diseases and liver metastasis of colorectal cancer[J/OL]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(07): 818-822.

结直肠癌肝转移是结直肠癌患者治疗失败的主要原因之一,对于影响肝转移的各种因素也成为结直肠癌的研究热点。肝脏自身基础疾病不仅影响肝脏的功能,而且还与结直肠癌肝转移具有密切的相关性。因此本文结合目前研究热点和进展,主要对肝脏基础疾病,如肝硬化、乙型病毒性肝炎和非酒精性脂肪肝对结直肠癌肝转移的影响及其具体的作用机制等研究进展进行综述,为今后的研究奠定理论基础。

Liver metastasis is one of the main reasons for treatment failure in patients with colorectal cancer, and factors affecting liver metastasis have become a research focus of colorectal cancer. The underlying liver diseases not only affect the function of the liver, but also have a close correlation with liver metastasis of colorectal cancer. This paper reviews the progress in the understanding of the relationship between underlying liver diseases, such as cirrhosis, viral hepatitis B, and non-alcoholic fatty liver, and liver metastasis of colorectal cancer and explores the possible mechanisms involved, laying a theoretical foundation for future research.

1
Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin, 2021, 71(3): 209-249.
2
Zheng R, Zhang S, Zeng H, et al. Cancer incidence and mortality in China, 2016 [J]. J Natl Cancer Cent, 2022, 2(1): 1-9.
3
中国医师协会外科医师分会, 中华医学会外科分会胃肠外科学组, 中华医学会外科分会结直肠外科学组, 等. 中国结直肠癌肝转移诊断和综合治疗指南(V2020) [J]. 中华胃肠外科杂志, 2021, 24(1): 1-13.
4
国家卫生健康委员会. 结直肠癌诊疗规范(2018年版) [J/OL]. 中华消化病与影像杂志(电子版), 2019, 9(3): 118-144.
5
中华医学会肝病学分会. 肝硬化诊治指南[J].中华肝脏病杂志, 2019, 27(11): 846-865.
6
Gunarathne LS, Rajapaksha H, Shackel N, et al. Cirrhotic portal hypertension: From pathophysiology to novel therapeutics [J]. World J Gastroenterol, 2020, 26(40): 6111-6140.
7
Lunova M, Frankova S, Gottfriedova H, et al. Portal hypertension is the main driver of liver stiffness in advanced liver cirrhosis [J]. Physiol Res, 2021, 70(4): 563-577.
8
Ginès P, Krag A, Abraldes JG, et al. Liver cirrhosis [J]. Lancet, 2021, 398(10308): 1359-1376.
9
Kaps L, Schuppan D. Targeting cancer associated fibroblasts in liver fibrosis and liver cancer using nanocarriers [J]. Cells, 2020, 9(9): 2027.
10
中华医学会肝病学分会, 中华医学会消化病学分会, 中华医学会感染病学分会. 肝纤维化诊断及治疗共识(2019年) [J]. 中华肝脏病杂志, 2019, 27(9): 657-667.
11
Barry AE, Baldeosingh R, Lamm R, et al. Hepatic stellate cells and hepatocarcinogenesis [J]. Front Cell Dev Biol, 2020, 8: 709.
12
Wu Y, Cao Y, Xu K, et al. Dynamically remodeled hepatic extracellular matrix predicts prognosis of early-stage cirrhosis [J]. Cell Death Dis, 2021, 12(2): 163.
13
Cao J, Luo SM, Liang L, et al. Effects of parenteral nutrition without and with growth hormone on growth hormone/insulin-like growth factor-1 axis after hepatectomy in hepatocellular carcinoma with liver cirrhosis [J]. JPEN J Parenter Enteral Nutr, 2007, 31(6): 496-501.
14
Anzo M, Cobb LJ, Hwang DL, et al. Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression [J]. Cancer Res, 2008, 68(9): 3342-3349.
15
Holdaway IM, Mason BH, Lethaby AE, et al. Serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 following chemotherapy for advanced breast cancer [J]. ANZ J Surg, 2003, 73(11): 905-908.
16
Kasprzak A. Insulin-Like growth factor 1 (IGF-1) signaling in glucose metabolism in colorectal cancer [J]. Int J Mol Sci, 2021, 22(12): 6434.
17
Sanchez-Lopez E, Flashner-Abramson E, Shalapour S, et al. Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling [J]. Oncogene, 2016, 35(20): 2634-44.
18
Lee HK, Lee JH, Kim M, et al. Insulin-like growth factor-1 induces migration and expression of laminin-5 in cultured human corneal epithelial cell [J]. Invest Ophthalmol Vis Sci, 2006, 47(3): 873-882.
19
Livingstone C. IGF2 and cancer [J]. Endocr Relat Cancer, 2013, 20(6): R321-39.
20
Song BC, Chung YH, Kim JA, et al. Association between insulin-like growth factor-2 and metastases after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma: a prospective study [J]. Cancer, 2001, 91(12): 2386-2393.
21
Feng X, Aleem E, Lin Y, et al. Multiple antitumor effects of picropodophyllin in colon carcinoma cell lines: clinical implications [J]. Int J Oncol, 2012, 40(4): 1251-1258.
22
Kasprzak A, Adamek A. Insulin-like growth factor 2 (IGF2) signaling in colorectal cancer-from basic research to potential clinical applications [J]. Int J Mol Sci, 2019, 20(19): 4915.
23
Lv J, Liu C, Chen FK, et al. M2-like tumour-associated macrophage-secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway [J]. Mol Med Rep, 2021, 24(2): 604.
24
Chen Y, Tian Z. HBV-Induced immune imbalance in the development of HCC [J]. Front Immunol, 2019, 10: 2048.
25
Kuppen PJ, Gorter A, Hagenaars M, et al. Role of NK cells in adoptive immunotherapy of metastatic colorectal cancer in a syngeneic rat model [J]. Immunol Rev, 2001, 184: 236-43.
26
Shimasaki N, Jain A, Campana D. NK cells for cancer immunotherapy [J]. Nat Rev Drug Discov, 2020, 19(3): 200-218.
27
Jiang K, Chen H, Fang Y, et al. Exosomal ANGPTL1 attenuates colorectal cancer liver metastasis by regulating Kupffer cell secretion pattern and impeding MMP9 induced vascular leakiness [J]. J Exp Clin Cancer Res, 2021, 40(1): 21.
28
Chen LM, Fan XG, Ma J, et al. Molecular mechanisms of HBeAg in persistent HBV infection [J]. Hepatol Int, 2017, 11(1): 79-86.
29
Zhang GL, Zhao QY, Xie C, et al. Elevated serum IgG levels positively correlated with IL-27 may indicate poor outcome in patients with HBV-Related acute-on-chronic liver failure [J]. J Immunol Res, 2019, 2019: 1538439.
30
Suga M, Arima K, Yachi A. Detection of IgM, IgA, and IgG antibodies to preS2 antigen in hepatitis B virus infection [J]. Digestion, 1991, 50(3-4): 153-161.
31
Li Q, Lu Q, Zhu MQ, et al. Lower level of complement component C3 and C3a in the plasma means poor outcome in the patients with hepatitis B virus related acute-on-chronic liver failure [J]. BMC Gastroenterol, 2020, 20(1): 106.
32
Faille D, Labreuche J, Meseguer E, et al. Endothelial markers are associated with thrombolysis resistance in acute stroke patients [J]. Eur J Neurol, 2014, 21(4): 643-647.
33
Tunçbilek S. Relationship between cytokine gene polymorphisms and chronic hepatitis B virus infection [J]. World J Gastroenterol, 2014, 20(20): 6226-6235.
34
Navi BB, Sherman CP, Genova R, et al. Mechanisms of Ischemic Stroke in Patients with Cancer: A Prospective Study [J]. Ann Neurol, 2021, 90(1): 159-169.
35
Sutton CD, O'Byrne K, Goddard JC, et al. Expression of thrombospondin-1 in resected colorectal liver metastases predicts poor prognosis [J]. Clin Cancer Res, 2005, 11(18): 6567-6573.
36
Teraoku H, Morine Y, Ikemoto T, et al. Role of thrombospondin-1 expression in colorectal liver metastasis and its molecular mechanism [J]. J Hepatobiliary Pancreat Sci, 2016, 23(9): 565-73.
37
Tokunaga T, Nakamura M, Oshika Y, et al. Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer [J]. Br J Cancer, 1999, 79(2): 354-359.
38
Yoshida N, Kinugasa T, Miyoshi H, et al. A high RORγT/CD3 ratio is a strong prognostic factor for postoperative survival in advanced colorectal cancer: analysis of helper T cell lymphocytes (Th1, Th2, Th17 and Regulatory T Cells) [J]. Ann Surg Oncol, 2016, 23(3): 919-9+27.
39
Lee JY, Seo EH, Oh CS, et al. Impact of circulating T helper 1 and 17 cells in the blood on regional lymph node invasion in colorectal cancer [J]. J Cancer, 2017, 8(7): 1249-1254.
40
von Lilienfeld-Toal M, Nattermann J, Feldmann G, et al. Activated gammadelta T cells express the natural cytotoxicity receptor natural killer p 44 and show cytotoxic activity against myeloma cells [J]. Clin Exp Immunol, 2006, 144(3): 528-33.
41
Xiao L, Cen D, Gan H, et al. Adoptive transfer of NKG2D CAR mRNA-engineered natural killer cells in colorectal cancer patients [J]. Mol Ther, 2019, 27(6): 1114-1125.
42
Cappuzzello E, Sommaggio R, Zanovello P, et al. Cytokines for the induction of antitumor effectors: The paradigm of Cytokine-Induced Killer (CIK) cells [J]. Cytokine Growth Factor Rev, 2017, 36: 99-105.
43
Ewen EM, Pahl JHW, Miller M, et al. KIR downregulation by IL-12/15/18 unleashes human NK cells from KIR/HLA-I inhibition and enhances killing of tumor cells [J]. Eur J Immunol, 2018, 48(2): 355-365.
44
Van der Meer JMR, Maas RJA, Guldevall K, et al. IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34+ progenitor-derived NK cells [J]. Cancer Immunol Immunother, 2021, 70(5): 1305-1321.
45
Lusty E, Poznanski SM, Kwofie K, et al. IL-18/IL-15/IL-12 synergy induces elevated and prolonged IFN-γ production by ex vivo expanded NK cells which is not due to enhanced STAT4 activation [J]. Mol Immunol, 2017, 88: 138-147.
46
Kondo T, Okabayashi K, Hasegawa H, et al. The impact of hepatic fibrosis on the incidence of liver metastasis from colorectal cancer [J]. Br J Cancer, 2016, 115(1): 34-39.
47
Kanzaki M, Wada J, Nakatsuka A, et al. A case of type 2 diabetes and metastatic liver cancer exhibiting hypercholesterolemia with abnormal lipoprotein [J]. Intern Med, 2012, 51(6): 619-623.
48
Li Y, Su X, Rohatgi N, Zhang Y, et al. Hepatic lipids promote liver metastasis [J]. JCI Insight, 2020, 5(17): e136215.
49
Sun X, Essalmani R, Day R, et al. Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver [J]. Neoplasia, 2012, 14(12): 1122-1131.
50
Kusama T, Mukai M, Iwasaki T, et al. 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis [J]. Gastroenterology, 2002, 122(2): 308-317.
51
Ling Y, Yang L, Huang H, et al. Prognostic significance of statin use in colorectal cancer: A systematic review and meta-analysis [J]. Medicine (Baltimore), 2015, 94(25): e908.
52
Verna L, Ganda C, Stemerman MB. In vivo low-density lipoprotein exposure induces intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 correlated with activator protein-1 expression [J]. Arterioscler Thromb Vasc Biol, 2006, 26(6): 1344-1349.
[1] 卢天祺, 张巍, 周康, 毕士玉, 张羽, 杨秀华. 血流向量成像技术在不同Child-Pugh分级乙肝患者左心功能评价中的价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(04): 352-360.
[2] 袁庆港, 刘理想, 张亮, 周世振, 高波, 丁超, 管文贤. 尿素-肌酐比值(UCR)可预测结直肠癌患者术后的长期预后[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(05): 506-509.
[3] 谢丽春, 欧庆芬, 张秋萍, 叶升. 简化和标准肝脏MRI方案在结直肠癌肝转移患者随访中的临床应用[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(04): 434-437.
[4] 贺健, 张骊, 王洪海, 蒋文涛. 肝移植术后脾功能亢进转归及治疗研究进展[J/OL]. 中华移植杂志(电子版), 2024, 18(05): 310-314.
[5] 王浩源, 汪海洋, 孙建明, 陈以宽, 祁小桐, 唐博. 腹腔镜与开放修补对肝硬化腹外疝患者肝功能及凝血的影响[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 654-659.
[6] 陈樽, 王平, 金华, 周美玲, 李青青, 黄永刚. 肌肉减少症预测结直肠癌术后切口疝发生的应用研究[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 639-644.
[7] 蔡艺丹, 方坚, 张志强, 陈莉, 张世安, 夏磊, 阮梅, 李东良. 经颈静脉肝内门体分流术对肝硬化门脉高压患者肠道菌群及肝功能的影响[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(05): 285-293.
[8] 邓万玉, 陈富, 许磊波. 肝硬化与非肝硬化乙肝相关性肝癌患者术后无复发生存比较及其影响因素分析[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 670-674.
[9] 赵泽云, 李建男, 王旻. 中性粒细胞胞外诱捕网在结直肠癌中的研究进展[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 524-528.
[10] 韩加刚, 王振军. 梗阻性左半结肠癌的治疗策略[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(06): 450-458.
[11] 王国强, 张纲, 唐建坡, 张玉国, 杨永江. LINC00839 调节miR-17-5p/WEE1 轴对结直肠癌细胞增殖、凋亡和迁移的影响[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 491-499.
[12] 孙晗, 于冰, 武侠, 周熙朗. 基于循环肿瘤DNA 甲基化的结直肠癌筛查预测模型的构建与验证[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 500-506.
[13] 陈倩倩, 袁晨, 刘基, 尹婷婷. 多层螺旋CT 参数、癌胚抗原、错配修复基因及病理指标对结直肠癌预后的影响[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 507-511.
[14] 崔健, 夏青, 林云, 李光玲, 李心娜, 王位. 血小板与淋巴细胞比值、免疫球蛋白、心肌酶谱及心电图对中老年肝硬化患者病情及预后的影响[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 400-406.
[15] 王湛, 李文坤, 杨奕, 徐芳, 周敏思, 苏珈仪, 王亚丹, 吴静. 炎症指标在早发性结直肠肿瘤中的应用[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 802-810.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?