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中华临床医师杂志(电子版)

中华临床医师杂志(电子版) ›› 2019, Vol. 13 ›› Issue (02) : 136 -140. doi: 10.3877/cma.j.issn.1674-0785.2019.02.011

所属专题： 文献；

综述

间充质干细胞向软骨细胞表型分化的研究进展
张芝良1, 李鹏翠1, 卫小春1,†()   
  1. 1. 030001　太原，山西医科大学第二医院骨科
  • 收稿日期:2018-10-31 出版日期:2019-01-15
  • 通信作者: 卫小春
  • 基金资助:
    国家自然科学基金青年基金(81601949); 山西省回国留学人员科研资助项目(2016-118)

Progress in research of differentiation of mesenchymal stem cells into chondrocytes

Zhiliang Zhang1, Pengcui Li1, Xiaochun Wei1,†()   

  1. 1. Department of Orthopedics, the Second Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China
  • Received:2018-10-31 Published:2019-01-15
  • Corresponding author: Xiaochun Wei
  • About author:
    Corresponding author: Wei Xiaochun, Email:
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张芝良, 李鹏翠, 卫小春. 间充质干细胞向软骨细胞表型分化的研究进展[J]. 中华临床医师杂志(电子版), 2019, 13(02): 136-140.

Zhiliang Zhang, Pengcui Li, Xiaochun Wei. Progress in research of differentiation of mesenchymal stem cells into chondrocytes[J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(02): 136-140.

软骨细胞是关节软骨中唯一的细胞，负责维持细胞外基质的稳态与平衡，软骨细胞数量的丢失和功能的失衡在骨关节炎的发病中起关键作用。但是由于关节软骨几乎没有再生能力，目前临床上用来治疗关节软骨缺损的方法和药物难以获得满意的疗效。软骨组织工程致力于通过人工手段在体内外生成透明软骨，为关节软骨缺损的修复提供了一条新的方法。间充质干细胞作为软骨组织工程的种子细胞可在特定诱导条件下分化为软骨细胞。因此，阐明该过程中软骨形成的相关转录因子和具体机制对于未来软骨再生医学的成功至关重要。

关键词: 间充质干细胞, 软骨细胞, 分化, 软骨修复

Chondrocytes are the only cells in articular cartilage, responsible for maintaining the homeostasis and balance of the extracellular matrix. The loss of chondrocyte number and functional imbalance play a key role in the pathogenesis of osteoarthritis. However, because the articular cartilage has almost no regenerative capacity, it is difficult to obtain satisfactory results using the methods and drugs currently used to treat articular cartilage defects. Cartilage tissue engineering aims to generate hyaline cartilage in vitro and in vivo by artificial means, providing a new method for the repair of articular cartilage defects. Mesenchymal stem cells, as seed cells of cartilage tissue engineering, can differentiate into chondrocytes under specific induction conditions. Therefore, elucidating the relevant factors and specific mechanisms of cartilage formation in this process is critical to the success of future cartilage regenerative medicine. This article is intended to provide an overview of this topic.

Key words: Mesenchymal stem cells, Chondrocytes, Differentiation, Cartilage repair
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