| 1 |
Vaillancourt M, Ruffenach G, Meloche J, et al. Adaptation and remodelling of the pulmonary circulation in pulmonary hypertension [J]. Can J Cardiol, 2015, 31(4): 407-415.
|
| 2 |
Alexander MR, Owens GK. Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease [J]. Annu Rev Physiol, 2012, 74: 13-40.
|
| 3 |
Xu D, Li Y, Zhang B, et al. Resveratrol alleviate hypoxic pulmonary hypertension via anti-inflammation and anti-oxidant pathways in rats [J]. Int J Med Sci, 2016, 13(12): 942-954.
|
| 4 |
Naeije R, Dedobbeleer C. Pulmonary hypertension and the right ventricle in hypoxia [J]. Exp Physiol, 2013, 98(8): 1247-1256.
|
| 5 |
Nogueira-Ferreira R, Vitorino R, Ferreira R, et al. Exploring the monocrotaline animal model for the study of pulmonary arterial hypertension: A network approach [J]. Pulm Pharmacol Ther, 2015, 35: 8-16.
|
| 6 |
Gomez-Arroyo J, Saleem SJ, Mizuno S, et al. A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects [J]. Am J Physiol Lung Cell Mol Physiol, 2012, 302(10): L977-L991.
|
| 7 |
Strobl M, Schreiber C, Panzenböck A, et al. Exhaled nitric oxide measurement to monitor pulmonary hypertension in a pneumonectomy-monocrotaline rat model [J]. Am J Physiol Lung Cell Mol Physiol, 2013, 305(7): 485-490.
|
| 8 |
Soon E, Crosby A, Southwood M, et al. Bone morphogenetic protein receptor type II deficiency and increased inflammatory cytokine production. A gateway to pulmonary arterial hypertension [J]. Am J Respir Crit Care Med, 2015, 192(7): 859-872.
|
| 9 |
Davies RJ, Holmes AM, Deighton J, et al. BMP type II receptor deficiency confers resistance to growth inhibition by TGF-beta in pulmonary artery smooth muscle cells: role of proinflammatory cytokines [J]. Am J Physiol Lung Cell Mol Physiol, 2012, 302(6): L604-L615.
|
| 10 |
Calvier L, Chouvarine P, Legchenko E, et al. PPARγ links BMP2 and TGFβ1 pathways in vascular smooth muscle cells, regulating cell proliferation and glucose metabolism [J]. Cell Metab, 2017, 25(5): 1118-1134.
|
| 11 |
Shimoda LA, Polak J. Hypoxia. 4. Hypoxia and ion channel function [J]. Am J Physiol Cell Physiol, 2011, 300(5): C951-C967.
|
| 12 |
Song S, Yamamura A, Yamamura H, et al. Flow shear stress enhances intracellular Ca2＋ signaling in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension [J]. Am J Physiol Cell Physiol, 2014, 307(4): C373-C383.
|
| 13 |
王益波, 马改改, 陈安, 等. 特发性肺动脉高压发病机制的新进展 [J]. 中国循环杂志, 2015, 30(6): 605-607.
|
| 14 |
Bonnet S, Rochefort G, Sutendra G, et al. The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted [J]. Proc Natl Acad Sci USA, 2007, 104(27): 11418-11423.
|
| 15 |
Hayabuchi Y. The action of smooth muscle cell potassium channels in the pathology of pulmonary arterial hypertension [J]. Pediatr Cardiol, 2017, 38(1): 1-14.
|
| 16 |
Huetsch JC, Jiang H, Larrain C, et al. The Na＋/H＋ exchanger contributes to increased smooth muscle proliferation and migration in a rat model of pulmonary arterial hypertension [J]. Physiol Rep, 2016, 4(5). pii: e12729.
|
| 17 |
Huetsch J, Shimoda LA. Na(＋)/H(＋) exchange and hypoxic pulmonary hypertension [J]. Pulm Circ, 2015, 5(2): 228-243.
|
| 18 |
Yu L, Hales CA. Silencing of sodium-hydrogen exchanger 1 attenuates the proliferation, hypertrophy, and migration of pulmonary artery smooth muscle cells via E2F1 [J]. Am J Respir Cell Mol Biol, 2011, 45(5): 923-930.
|
| 19 |
王瑾, 向莉莉, 李晓晖. 骨形成蛋白Ⅱ型受体信号通路与肺动脉高压:新进展与希望 [J]. 中国药理学与毒理学杂志, 2017, 31(2): 119-130.
|
| 20 |
Cai J, Pardali E, Sanchez-Duffhues G, et al. BMP signaling in vascular diseases [J]. FEBS letters, 2012, 586(14): 1993-2002.
|
| 21 |
Lowery JW, de Caestecker MP. BMP signaling in vascular development and disease [J]. Cytokine Growth Factor Rev, 2010, 21(4): 287-298.
|
| 22 |
Yang J, Li X, Al-Lamki RS, et al. Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension [J]. Arterioscler Thromb Vasc Biol, 2013, 33(1): 34-42.
|
| 23 |
Broege A, Pham L, Jensen ED, et al. Bone morphogenetic proteins signal via SMAD and mitogen-activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis [J]. J Biol Chem, 2013, 288(52): 37230-37240.
|
| 24 |
Soubrier F, Chung WK, Machado R, et al. Genetics and genomics of pulmonary arterial hypertension [J]. Turk Kardiyol Dern Ars, 2014, 42 Suppl 1: 17-28.
|
| 25 |
Diebold I, Hennigs J, Miyagawa K, et al. BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension [J]. Cell Metab, 2015, 21(4): 596-608.
|
| 26 |
Hopper RK, Moonen JA, Diebold I, et al. In pulmonary arterial hypertension, reduced BMPR2 promotes endothelial-to-mesenchymal transition via HMGA1 and its target Slug [J]. Circulation, 2016, 133(18): 1783-1794.
|
| 27 |
Orriols M, Gomez-Puerto MC, Ten Dijke P. BMP type Ⅱ receptor as a therapeutic target in pulmonary arterial hypertension [J]. Cell Mol Life Sci, 2017, 74(16): 2979-2995.
|
| 28 |
Meloche J, Pflieger A, Vaillancourt M, et al. Role for DNA damage signaling in pulmonary arterial hypertension [J]. Circulation, 2014, 129(7): 786-797.
|
| 29 |
Li M, Vattulainen S, Aho J, et al. Loss of bone morphogenetic protein receptor 2 is associated with abnormal DNA repair in pulmonary arterial hypertension [J]. Am J Respir Cell Mol Biol, 2014, 50(6): 1118-1128.
|
| 30 |
Khadka A, Singh Brashier DB, Tejus A, et al. Macitentan: An important addition to the treatment of pulmonary arterial hypertension [J]. J Pharmacol Pharmacother, 2015, 6(1): 53-57.
|
| 31 |
Yu J, Taylor L, Wilson J, et al. Altered expression and signal transduction of endothelin-1 receptors in heritable and idiopathic pulmonary arterial hypertension [J]. J Cell Physiol, 2013, 228(2): 322-329.
|
| 32 |
Kij A, Mateuszuk L, Sitek B, et al. Simultaneous quantification of PGI2 and TXA2 metabolites in plasma and urine in NO-deficient mice by a novel UHPLC/MS/MS method [J]. J Pharm Biomed Anal, 2016, 129: 148-154.
|
| 33 |
Falcetti E, Hall SM, Phillips PG, et al. Smooth muscle proliferation and role of the prostacyclin (IP) receptor in idiopathic pulmonary arterial hypertension [J]. Am J Respir Crit Care Med, 2010, 182(9): 1161-1170.
|
| 34 |
Chu LY, Liou JY, Wu KK. Prostacyclin protects vascular integrity via PPAR/14-3-3 pathway [J]. Prostaglandins Other Lipid Media, 2015, 118-119: 19-27.
|
| 35 |
Chen YC, Chu LY, Yang SF, et al. Prostacyclin and PPARalpha agonists control vascular smooth muscle cell apoptosis and phenotypic switch through distinct 14-3-3 isoforms [J]. PloS one, 2013, 8(7): e69702.
|
| 36 |
Romero M, Toral M, Robles-Vera I, et al. Activation of peroxisome proliferator activator receptor β/δ improves endothelial dysfunction and protects kidney in murine lupus [J]. Hypertension, 2017, 69(4): 641-650.
|
| 37 |
Ahmadian M, Suh JM, Hah N, et al. PPARgamma signaling and metabolism: the good, the bad and the future [J]. Nat Med, 2013, 19(5): 557-566.
|
| 38 |
Liu Y, Tian XY, Mao G, et al. Peroxisome proliferator-activated receptor-gamma ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor [J]. Hypertension, 2012, 60(6): 1471-1478.
|
| 39 |
Bertero T, Cottrill K, Krauszman A, et al. The microRNA-130/301 family controls vasoconstriction in pulmonary hypertension [J]. J Biol Chem, 2015, 290(4): 2069-2085.
|
| 40 |
Bertero T, Yu L, Annis S, et al. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension [J]. J Clin Invest, 2014, 124(8): 3514-3528.
|
| 41 |
Hansmann G, de Jesus Perez VA, Alastalo TP, et al. An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension [J]. J Clin Invest, 2008, 118(5): 1846-1857.
|
| 42 |
Chen YF, Feng JA, Li P, et al. Dominant negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary vascular remodeling [J]. J Appl Physiol, 2006, 100(2): 564-571.
|
| 43 |
Gong K, Xing D, Li P, et al. Hypoxia induces downregulation of PPAR-gamma in isolated pulmonary arterial smooth muscle cells and in rat lung via transforming growth factor-beta signaling [J]. Am J Physiol Lung Cell Mol Physiol, 2011, 301(6): L899-L907.
|
| 44 |
刘洪涛, 曾艳, 苟德明. 缺氧诱导因子1调控缺氧性肺动脉高压的研究进展 [J]. 中华高血压杂志, 2014, 22(7): 629-634.
|
| 45 |
Li Y, Shi B, Huang L, et al. Suppression of the expression of hypoxia-inducible factor-1alpha by RNA interference alleviates hypoxia-induced pulmonary hypertension in adult rats [J]. Int J Mol Med, 2016, 38(6): 1786-1794.
|
| 46 |
Abud EM, Maylor J, Undem C, et al. Digoxin inhibits development of hypoxic pulmonary hypertension in mice [J]. Proc Natl Acad Sci U S A, 2012, 109(4): 1239-1244.
|