儿童周期性呕吐综合征诊治进展

doi:10.3877/cma.j.issn.1674-0785.2019.03.014

中华临床医师杂志(电子版) ›› 2019, Vol. 13 ›› Issue (03) : 225 -228. doi: 10.3877/cma.j.issn.1674-0785.2019.03.014

所属专题：文献；

综述

儿童周期性呕吐综合征诊治进展

左都霜¹, 周小勤¹, 詹学¹^,^†(

)

^1. 400014　重庆医科大学附属儿童医院消化科　儿童发育疾病研究教育部重点实验室　儿科学重庆市重点实验室　儿童发育重大疾病国家国际科技合作基地

收稿日期:2018-11-15 出版日期:2019-02-01
通信作者: 詹学
基金资助:
国家自然科学基金青年基金项目(81601973)

Progress in diagnosis and treatment of cyclic vomiting syndrome in children

Dushuang Zuo¹, Xiaoqin Zhou¹, Xue Zhan¹^,^†()

^1. Department of Gastroenterology, Children′s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing 400014, China

Received:2018-11-15 Published:2019-02-01
Corresponding author: Xue Zhan
About author:
Corresponding author: Zhan Xue, Email: zhanxue@hotmail.com

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周期性呕吐综合征（CVS）是以刻板的、反复发作的剧烈恶心、呕吐为特点的一组综合征，发作持续数小时至数天，发作间期恢复基础健康状态。CVS的发病机制尚不明确，至今无特异性检查方法，诊断依赖于临床表现，目前诊断多采用罗马Ⅳ标准，治疗上暂无标准方案，以经验性治疗为主。本文主要从CVS的诊断和治疗方面进行综述。

关键词: 周期性呕吐综合征, 诊断, 治疗, 儿童

Cyclic vomiting syndrome (CVS) is a syndrome characterized by stereotypical, recurrent episodes of severe nausea and vomiting. Episodes can last from a few hours to several days, and it returns to baseline health during inter-episodic phase. Since the pathogenesis is unknown, and there are no specific biomarkers available for this disorder, the diagnosis often relies on clinical features. Due to the aforementioned reasons, delayed diagnosis is often caused. The Rome IV is the most used criteria for CVS diagnosis. But so far, no standard therapeutic regimen currently exists to manage CVS, and the treatment is primarily empirical. This review mainly summarizes the diagnosis and treatment of CVS.

Key words: Cyclic vomiting syndrome, Diagnosis, Treatment, Children

图1 儿童CVS的诊断流程图

表1 CVS急性治疗时阿瑞匹坦用法用量

体质量（kg）	阿瑞匹坦剂量（mg/d）
体质量（kg）	第1天	第2天	第3天
<15	80	40	40
15~20	80	80	80
>20	125	80	80

表1 CVS急性治疗时阿瑞匹坦用法用量

体质量（kg）	阿瑞匹坦剂量（mg/d）
体质量（kg）	第1天	第2天	第3天
<15	80	40	40
15~20	80	80	80
>20	125	80	80

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